Results 191 to 200 of about 21,088 (210)

Epimerization and Hydrolysis of Dalvastatin, a New Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor

Pharmaceutical Research, 1994
In aqueous solutions, dalvastatin (1) undergoes epimerization as well as hydrolysis. The transformation of the drug was studied as a function of pH at 25 degrees C in aqueous solutions containing 20% acetonitrile. At all pH values, first-order plots for the conversion are biphasic, indicating rapid equilibration of 1 with its epimer (2) and slower ...
openaire   +2 more sources

Research advances in pleiotropic effects of statins in elderly patients

, 2019
Wensen Yao
semanticscholar   +1 more source

Bone induction using hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

2010
ABSTRACT Objectives. The search of a non-toxic material to replace bone remains a big challenge for scientists. Previous studies examined more than 30 000 compounds from a collection of natural products and identified that statins, commonly used hydroxymethylglutaryl coenzyme A reductase inhibitors (HMGRIs), increased expression of the morphogenetic ...
Rabie, ABM, Wong, RWK
openaire   +1 more source

Hydroxymethylglutaryl-CoA Reductase

2007
Sutherlin, A.L., Stauffacher, C.V., Bochar, D.A., Tabernero, L., Hedl, M., Rodwell, V.W.   +5 more
openaire   +3 more sources

The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

High cholesterol and triglyceride levels are mainly related to further generation of life-threating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled.
Gulcan, Hayrettin Ozan, Yigitkan, Serkan, Orhan, Ilkay Erdogan   +2 more
openaire   +1 more source

Hydroxymethylglutaryl-CoA reductase (NADPH)

1995
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

[Hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase

1991
Dietmar Schomburg, Margit Salzmann
openaire   +1 more source

[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Hydroxymethylglutaryl‐CoA reductase (NADPH) activity in rat brain during development

Journal of Neurochemistry, 1978
M C, Aragon, C, Gimenez, F, Valdivieso, F, Mayor   +3 more
openaire   +2 more sources

G.P.211 Effects of auto-antibodies anti-signal recognition particle (SRP) and anti-hydroxymethylglutaryl-CoA reductase (HMGCR) on muscle cells

Neuromuscular Disorders, 2015
L. Arouche-Delaperche, G. Butler-Browne, O. Benveniste   +2 more
semanticscholar   +1 more source