Results 31 to 40 of about 80,142 (184)

Inhibition of protein synthesis blocks the response to 25-hydroxycholesterol by inhibiting degradation of hydroxymethylglutaryl-CoA reductase.

, 1982
The activity of the rate-limiting enzyme of the cholesterol biosynthetic pathway, 3-hydroxy-3-methylglutaryl coenzyme A reductase in Chinese hamster ovary (CHO) cells decreased more rapidly in cells treated with 25-hydroxycholesterol alone (t 1/2 = 1 ...
Kandutsch, A A, Chen, H W, Richards, B A
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Association mapping for hop cone chemistry and morphology identifies natural beneficial allele stacks

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Efforts are underway to increase the efficiency and precision of selection hop (Humulus lupulus L.) breeding using genomics. Little is known, however, about the genetic control of important traits like α‐and β‐acids contents, oil content, and cone morphological characteristics, all of which play an important role in determining the utility and
Shaun J. Clare, Peter Schmuker, Kayla Altendorf   +2 more
wiley   +1 more source

The 3-Hydroxy-3-Methylglutaryl Coenzyme-A (HMG-CoA) Reductases [PDF]

, 2004
The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is the rate-limiting step in the synthesis of cholesterol and other isoprenoids.
Friesen, Jon A, Rodwell, Victor W
core   +1 more source

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1687-1691, June 2026.
ABSTRACT Background Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged ≥ 80 years remains limited. This study aimed to evaluate the long‐term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older.
Ophir Lavon, Wafaa Hamodi, Sameer Kassem
wiley   +1 more source

Uso crônico e regular de estatina previne fibrilação atrial no pós-operatório de cirurgia cardíaca Chronic and regular use of statin prevents atrial fibrillation in period after cardiac surgery

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: Fibrilação atrial é uma complicação frequente no pós-operatório de cirurgia cardíaca. O uso prévio de estatinas pode reduzir a incidência dessa arritmia.
Renato Jorge Alves, Rodrigo Noronha Campos, Kenji Nakiri   +2 more
doaj  

Indirect Assessment of Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity in Liver Tissue

Clinical Chemistry, 1975
Abstract We describe an indirect method for assessing variation in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (NADPH) activity in liver tissue. 3-Hydroxy-3-methylglutaryl-CoA and mevalonate concentrations in the tissue homogenate are estimated in terms of absorbances and the ratio between the two is taken as an index of activity of ...
A V, Rao, S, Ramakrishnan
openaire   +2 more sources

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, Volume 299, Issue 5, Page 628-638, May 2026.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

Current Trends, Future Prospects and Constraints of Whole Microalgae and Their Fractions as a Functional Feed Ingredient for Animals

Journal of Animal Physiology and Animal Nutrition, Volume 110, Issue 3, Page 324-338, May 2026.
ABSTRACT Microalgae are a highly diverse group of unicellular organisms that grow in a wide range of aquatic environments and are widely used as dietary supplements for both human and animal applications. Microalgae are rich in lipids, proteins, carbohydrates and other valuable bioactive components such as pigments, antioxidants and vitamins.
Sietse Jan Koopmans, Simon Roques, Edoardo Zaccaria, Annemarie Mens, Soumya Kanti Kar   +4 more
wiley   +1 more source

Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre‐Implant Bone Regeneration: A Systematic Review and Meta‐Analysis

Clinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objectives This systematic review and meta‐analysis aimed to evaluate the adjunctive beneficial effects of locally delivered statins on probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BoP), and radiographic bone outcomes in both periodontal therapy (Step 2 non‐surgical periodontal therapy and Step 3 ...
Koki Yoshida, Sofia Heller, Nur Mousa, Lovisa Olén, Farah Asa'ad   +4 more
wiley   +1 more source

Identification Of Genes Encoding Acyl-coa Reductases And Aldehyde Reductases In Mycobacterial Genome By Characterization Of The Reductases Expressed In E. Coli [PDF]

, 2007
Mycobacterium tuberculosis has been long known to produce wax esters. However, the enzymes involved in their biosynthesis have not been identified. Here we report the identification of Rv3391 and Rv1543 as genes that encode fatty acyl-CoA reductases and ...
Singh, Harminder
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