Results 31 to 40 of about 1,557 (185)

Laboratory tests and clinical significance of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibody

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibody is a newly recognized autoantibody, which is associated with the use of statins and is considered as an immunological marker of necrotizing autoimmune myopathy (NAM).
Jing-jing LUO, Feng GAO, Jie-xi WEN, Hong-jun HAO, Jing GUO, Yi-ning HUANG   +5 more
doaj  

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, Volume 299, Issue 5, Page 628-638, May 2026.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

A Unique Regulator Contributes to Quorum Sensing and Virulence in Burkholderia cenocepacia [PDF]

, 2012
Burkholderia cenocepacia causes chronic and life-threatening respiratory infections in immunocompromized people. The B. cenocepacia N-acyl-homoserine lactone (AHL)-dependent quorum sensing system relies on the production of AHLs by the synthases CepI and
A Baldwin, A Edwards, A Gotschlich, A Isles, A Marchler-Bauer, AC Vergunst, AM Jones, AV Patankar, B Huber, B Huber, B Huber, B Subsin, BW Holloway, C Aguilar, C Kooi, CD Sibley, CE Chambers, CL Weingart, CR Corbett, DH Figurski, DP Speert, Duber F. Viteri, E Mahenthiralingam, E Mahenthiralingam, Eoin P. O'Grady, EP O'Grady, EP O'Grady, F Ausubel, HA Cash, HP Schweizer, J Kim, J Lamothe, J Sambrook, J Zhu, Jamunarani Vadivelu, JJ Dennis, K Duan, K Riedel, KA Coggan, KL Tomlin, L Eberl, M Frederix, M Hedl, M Kothe, M Magalhaes, ME Kovach, MW Tan, P Williams, PA Sokol, PA Sokol, Pamela A. Sokol, PS Dehal, R Daniels, RJ Malott, RJ Malott, RP Ryan, RS Flannagan, S Brenner, S Lewenza, S Lewenza, S Lewenza, S Rozen, S Subramoni, S Subramoni, S Uehlinger, SA Loutet, SA McKeon, SP Bernier, SP Bernier, SP Bernier, TD Schmittgen, V Venturi, VL Miller, WL Ng, Y Wei   +74 more
core   +2 more sources

Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre‐Implant Bone Regeneration: A Systematic Review and Meta‐Analysis

Clinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objectives This systematic review and meta‐analysis aimed to evaluate the adjunctive beneficial effects of locally delivered statins on probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BoP), and radiographic bone outcomes in both periodontal therapy (Step 2 non‐surgical periodontal therapy and Step 3 ...
Koki Yoshida, Sofia Heller, Nur Mousa, Lovisa Olén, Farah Asa'ad   +4 more
wiley   +1 more source

Dual RNA-seq analysis provides new insights into interactions between Norway spruce and necrotrophic pathogen Heterobasidion annosum s.l. [PDF]

, 2019
BackgroundRoot and butt rot of conifer trees caused by fungi belonging to the Heterobasidion annosum species complex is one of the most economically important fungal diseases in commercial conifer plantations throughout the Northern hemisphere.
Asiegbu, Frederick Obioma, Ghimire, Rajendra P., Holopainen, Jarmo K., Julkunen-Tiitto, Riitta, Kasanen, Risto Aarne Olavi, Kivimäenpää, Minna, Kovalchuk, Andriy, Liu, Mengxia, Mukrimin, Mukrimin, Raffaello, Tommaso, Sun, Hui, Zeng, Zhen   +11 more
core   +5 more sources

'Candidatus Sarmatiella mevalonica' endosymbiont of the ciliate Paramecium provides insights on evolutionary plasticity among Rickettsiales [PDF]

, 2021
Members of the bacterial order Rickettsiales are obligatorily associated with a wide range of eukaryotic hosts. Their evolutionary trajectories, in particular concerning the origin of shared or differential traits among distant sub-lineages, are still ...
Castelli, Michele, Lanzoni, Olivia, Lometto, Stefano, Modeo, Letizia, Nardi, Tiago, Petroni, Giulio, Potekhin, Alexey, Sassera, Davide   +7 more
core   +1 more source

Pravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Endothelium‐dependent relaxation in isolated uterine radial arteries from normotensive (NT) and preeclamptic (PE) pregnancies, and the acute effects of pravastatin in the latter vessels were assessed. Pravastatin is hypothesized to alleviate endothelial dysfunction in PE via modulating aspects of NO and endothelium‐derived ...
Nathan M. Luque, Leo Leader, Sandra M. Lowe, Steven D. Horrowitz, Marianne Tare, Victoria Hinkley, Vladimir V. Matchkov, Maged M. Costantine, Irit Markus, Lu Liu, Shaun L. Sandow, Timothy V. Murphy   +11 more
wiley   +1 more source

Reduction of opioid and barbiturate use following initiation of rimegepant for migraine in the United States

Headache: The Journal of Head and Face Pain, Volume 66, Issue 4, Page 835-845, April 2026.
Abstract Objective The primary objective of this study was to evaluate opioid and barbiturate utilization before and after the first prescription of the calcitonin gene–related peptide receptor antagonist rimegepant in individuals with migraine. Background Although not recommended in migraine treatment guidelines, opioids and barbiturates are often ...
Noah Rosen, Aaron Jenkins, Karin Hygge Blakeman, Feng Dai, Lucy Abraham, Chelsea Leroue, Josh Brown   +6 more
wiley   +1 more source

Tomato hydroxymethylglutaryl-CoA reductase is required early in fruit development but not during ripening. [PDF]

The Plant Cell, 1989
The activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) and the level of its mRNA have been determined at various stages of tomato fruit development. The HMGR reaction makes mevalonate, a necessary component in the synthesis of all isoprene containing compounds, such as sterols and carotenoids.
J O, Narita, W, Gruissem
openaire   +2 more sources

Variation in Psychotropic and Non‐Psychotropic Prescribing in Nursing Homes: A Multi‐Level EMR‐Based Retrospective Cohort Study

Journal of the American Geriatrics Society, Volume 74, Issue 4, Page 1099-1109, April 2026.
ABSTRACT Background Antipsychotic medications remain widely used in nursing homes (NHs) despite guidelines discouraging potentially inappropriate use. While home‐level variation is known, less is understood at the unit and organization levels, or across other psychotropic and non‐psychotropic drugs.
Darly Dash, Ahmad Rahim, Henry Yu‐Hin Siu, Aaron Jones, Maya Potter, Sophiya Benjamin, Paul R. Katz, Jeffrey W. Poss, George A. Heckman, Andrew P. Costa   +9 more
wiley   +1 more source