Results 31 to 40 of about 1,232 (144)
Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders
Neuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan +5 more
wiley +1 more source
Inactivation of hydroxymethylglutaryl-CoA reductase from yeast by coenzyme A disulfide.
Journal of Biological Chemistry, 1981 The time-dependent inactivation of hydroxymethylglutaryl-CoA reductase from yeast by solutions of hydroxymethylglutaryl-CoA and CoASH is due to the rapid inactivation of the enzyme by oxidized CoA (CoA disulfide) present at trace levels in solutions of hydroxymethylglutaryl-CoA and CoASH.
H F, Gilbert, M D, Stewart
openaire +2 more sources
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.ABSTRACT The purpose was to evaluate retrieval‐augmented generative (RAG) artificial intelligence (AI) methods for assessing the regulatory compliance of drug information and adherence to best practices in clinical trial protocols. Integrated systems containing RAG and large language model (LLM) components were employed to evaluate drug information and
Shreyas Waikar +2 more
wiley +1 more source
Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects
, 1993 We measured biliary and fecal sterol outputs in 12 human sub-jects on a metabolic ward in four randomly allocated, 6-7 wk periods: (a) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/d), (b) lovastatin + high cholesterol diet (mean 1,071 mg/
William C. Duane
core
Atorvastatin‐Associated Liver Injury: Outcome After Statin Rechallenge
Fundamental &Clinical Pharmacology, Volume 40, Issue 2, March 2026.ABSTRACT Background Statin‐induced liver injury is frequent and usually not severe. The aim of the present study was to describe the safety of statin rechallenge after atorvastatin‐induced liver injury because it is poorly documented. Methods Cases of liver injury involving atorvastatin were selected from the French pharmacovigilance database ...
Blandine Bertin +5 more
wiley +1 more source
eJHaem, Volume 7, Issue 1, February 2026.ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3 (CCL3). While both bortezomib and statins have been reported
Fujun Qu +6 more
wiley +1 more source
The effect of oligomeric procyanidins on endothelial function and cholesterol homeostasis
, 2012 PhDOligomeric procyanidins (OPC) are naturally occurring dietary substances, which studies suggest can protect against cardiovascular disease. To explore this further a double-blind randomised controlled crossover trial, EPICURE (Evaluation of high ...
Rull, Gurvinder Kaur
core
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1984 The activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34), obtained from cultured human IM-9 lymphoid cells or freshly isolated human peripheral blood leukocytes, is modulated by a phosphorylation/dephosphorylation mechanism.
Division of Endocrinology and Metabolism, University of Florida, College of Medicine, Gainesville, FL 32610 U.S.A. ( host institution ) +3 more
openaire +3 more sources
Dietary Coenzyme Q10 Suppressed Hepatic Hydroxymethylglutaryl-CoA Reductase Activity in Laying Hens
Bioscience, Biotechnology, and Biochemistry, 2013 The effects of dietary coenzyme Q10 (CoQ10) on cholesterol metabolism in laying hens were investigated. Dietary CoQ10 significantly reduced egg yolk cholesterol content and suppressed hepatic hydroxymethylglutaryl-CoA reductase (HMGR) activity. It is therefore likely that CoQ10 acts as an HMGR inhibitor in the livers of laying hens, which in turn ...
HONDA, Kazuhisa +4 more
openaire +2 more sources
Inhibition of yeast hydroxymethylglutaryl‐CoA reductase by a rat liver mitochondrial preparation [PDF]
FEBS Letters, 1974 Madhosingh, C. +2 more
openaire +2 more sources