Results 51 to 60 of about 1,557 (185)
Atorvastatin‐Associated Liver Injury: Outcome After Statin Rechallenge
Fundamental &Clinical Pharmacology, Volume 40, Issue 2, March 2026.ABSTRACT Background Statin‐induced liver injury is frequent and usually not severe. The aim of the present study was to describe the safety of statin rechallenge after atorvastatin‐induced liver injury because it is poorly documented. Methods Cases of liver injury involving atorvastatin were selected from the French pharmacovigilance database ...
Blandine Bertin +5 more
wiley +1 more source
Crystal Structure of a Statin Bound to a Class II Hydroxymethylglutaryl-CoA Reductase
Journal of Biological Chemistry, 2003 Hydroxymethylglutaryl-CoA (HMG-CoA) reductase is the primary target in the current clinical treatment of hypercholesterolemias with specific inhibitors of the "statin" family. Statins are excellent inhibitors of the class I (human) enzyme but relatively poor inhibitors of the class II enzymes of important bacterial pathogens.
Tabernero, Lydia +2 more
openaire +2 more sources
Cloning of the Alcaligenes eutrophus genes for synthesis of poly-beta-hydroxybutyric acid (PHB) and synthesis of PHB in Escherichia coli [PDF]
, 1988 Eight mutants of Alcaligenes eutrophus defective in the intracellular accumulation of poly-beta-hydroxybutyric acid (PHB) were isolated after transposon Tn5 mutagenesis with the suicide vector pSUP5011.
P Schubert, A Steinbüchel, H G Schlegel
core +1 more source
eJHaem, Volume 7, Issue 1, February 2026.ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3 (CCL3). While both bortezomib and statins have been reported
Fujun Qu +6 more
wiley +1 more source
Rethinking Statin Dosage in Coronary Disease
Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.It is widely acknowledged that a sufficient statin dose is important in the management of symptomatic coronary disease, along with weight reduction and appropriate antithrombotic, blood pressure, and diabetes pharmacotherapy. Mid‐range statin doses have been shown to achieve the maximum improvements in total mortality and have the advantage of greater ...
Simon B. Dimmitt +3 more
wiley +1 more source
Inactivation of hydroxymethylglutaryl-CoA reductase from yeast by coenzyme A disulfide.
Journal of Biological Chemistry, 1981 The time-dependent inactivation of hydroxymethylglutaryl-CoA reductase from yeast by solutions of hydroxymethylglutaryl-CoA and CoASH is due to the rapid inactivation of the enzyme by oxidized CoA (CoA disulfide) present at trace levels in solutions of hydroxymethylglutaryl-CoA and CoASH.
H F, Gilbert, M D, Stewart
openaire +2 more sources
Quorum sensing for improved production of industrially useful products from filamentous fungi [PDF]
, 2014 Quorum sensing (QS) is a cell density dependant phenomena utilized as a communication process among microorganisms to regulate their physiological responses. QS depends on the production and release of low molecular weight, diffusible chemical signalling
Amache, R., Amache, R.
core
Medical Journal of Australia, Volume 224, Issue 2, February 2026.ABSTRACT Introduction The Australian clinical guideline for diagnosing and managing acute coronary syndromes 2025 establishes a new clinical standard for the diagnosis and management of acute coronary syndromes (ACS) in Australia. The new guideline replaces the 2016 guideline, representing the first major update in nearly a decade.
David B. Brieger +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou +9 more
wiley +1 more source
Statins for aortic valve stenosis [PDF]
, 2016 Background Aortic valve stenosis is the most common type of valvular heart disease in the USA and Europe. Aortic valve stenosis is considered similar to atherosclerotic disease.
Atallah, Álvaro Nagib +7 more
core +1 more source