Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis
Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi +7 more
wiley +1 more source
A proteomic analysis of Psychrobacter articus 273-4 adaptation to low temperature and salinity using a 2-D liquid mapping approach [PDF]
, 2007 Psychrobacter 273-4 was isolated from a 20 000–40 000–year-old Siberian permafrost core, which is characterized by low temperature, low water activity, and high salinity.
Lubman, David M. +5 more
core +1 more source
O impacto das revisões de literatura na ciência odontológica e na clínica periodontal : o exemplo de uma revisão sistemática de estatinas como adjuvante à terapia periodontal [PDF]
, 2017 As revisões sistemáticas são consideradas os desenhos experimentais capazes de guiar os cuidados em saúde. Contudo, as revisões narrativas ainda são largamente publicadas até o presente momento.
Muniz, Francisco Wilker Mustafa Gomes
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Optimization of de novo 10-hydroxygeraniol production in Saccharomyces cerevisiae [PDF]
, 2019 Monoterpenes and their indole alkaloid derivates are plant secondary metabolites valuable to the pharmaceutical and industrial sectors for their bioactivities in humans, cats and insects. The biosynthetic pathway to strictosidine, the central monoterpene
Davies, Meghan
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The design and realization of synthetic pathways for the fixation of carbon dioxide in vitro [PDF]
, 2018 The fixation of inorganic carbon and the conversion to organic molecules is a prerequisite for life and the foundation of the carbon cycle on Earth. Since the industrial revolution, this carbon cycle has become inbalanced and consequently the atmospheric
Schwander, Thomas
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Proceedings of the 39th Annual Biochemical Engineering Symposium [PDF]
, 2010 The 39th Annual Biochemical Engineering Symposium was held at Kansas State University on Saturday, April 17, 2010. The conference provides an opportunity for students to present their research to faculty and students from the participating universities ...
Erickson, Larry E.
core +2 more sources
Antimicrobial Potential of Hydroxymethylglutaryl-Coa Reductases Inhibitors
The 1st International Electronic Conference on Clinical Medicine, 2021 Hélida Maravilha Dantas e Sousa Almeida +2 more
openaire +1 more source
Determination of 3-Hydroxy-3-methylglutaryl CoA Reductase Activity in Plants
The enzyme 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase catalyzes the NADPH-mediated reductive deacylation of HMG-CoA to mevalonic acid, which is the first committed step of the mevalonate pathway for isoprenoid biosynthesis.
Arró i Plans, Montserrat +3 more
core +1 more source
Characterization of PksS in Bacillus subtilis [PDF]
, 2007 "Cytochrome P450s are a common type of the polyketide tailoring enzymes that are responsible for the hydroxylation of polyketides. PksS, a likely tailoring enzyme, is found within the gene cluster pksX, from Bacillus subtilis.
Antolak, Stephanie Anne +1 more
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Studies on the peroxisomal multifunctional enzyme type-1 : Domain structure with special reference to the hydratase/isomerase fold [PDF]
, 2001 The peroxisomal multifunctional enzyme type-1 (perMFE-1) is a monomeric protein of β-oxidation possessing 2-enoyl-CoA hydratase-1, Δ³-Δ²-enoyl-CoA isomerase, and (3S)-hydroxyacyl-CoA dehydrogenase activities.
Kiema, Tiila-Riikka
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