Results 11 to 20 of about 271 (119)
Advanced Science, Volume 13, Issue 12, 27 February 2026.Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han +16 more
wiley +1 more source
Validation of grizzly bear hair hormone profiles as a tool to monitor population demographics
The Journal of Wildlife Management, Volume 90, Issue 2, February 2026.We measured 16 steroid and thyroid hormone concentrations in grizzly bear hair to predict sex, age class, and reproductive status. Models were highly accurate when predicting sex and age class and showed promise for assessing reproductive status. Results illustrate the potential for hair hormone profiles as non‐invasive population monitoring tools ...
Abbey E. Wilson +10 more
wiley +1 more source
Clinical Endocrinology, Volume 104, Issue 2, Page 92-102, February 2026.ABSTRACT Background Mixed gonadal dysgenesis (MGD) is a rare form of differences in sex development (DSD) typically associated with 45,X/46,XY mosaicism. The phenotypic presentation of MGD varies from atypical genitalia to typical male or female appearances often associated with Turner stigmata.
Dinesh Giri +6 more
wiley +1 more source
Clinical Endocrinology, Volume 104, Issue 2, Page 123-129, February 2026.ABSTRACT Background Clinical outcome studies of 21‐hydroxylase deficiency congenital adrenal hyperplasia (21OHD CAH) may be subject to selection bias due to incomplete case ascertainment. This study aimed to develop a methodology for identifying existing CAH cases and explore its utility to study clinical outcomes. Methods 17‐hydroxyprogesterone assays
Joseph McElvaney +7 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1392-1402, February 2026.Abstract Aim CD4 + CD25highCD127‐T regulatory cells (Tregs) remain a drug candidate for immunotherapy of type 1 diabetes. We completed three trials testing Tregs in recently diagnosed type 1 diabetes children. Here, we looked for long‐term safety and efficacy aspects important in the authorisation of this therapy.
Marta Bandura +18 more
wiley +1 more source
Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors
Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.Human bitter taste receptors are not only involved in sensing tastants within the oral cavity but also play crucial roles in internal tissues of the body. The current report identifies numerous structurally and functionally diverse steroid hormones as activators of the two human bitter taste receptors, TAS2R14 and TAS2R46.
Tatjana Lang +4 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Aldosterone synthase deficiency is a rare cause of neonatal salt‐wasting and failure to thrive. Routine newborn electrolyte screening after 5 days of life is vital for early detection and prevention of life‐threatening crises. Genetic confirmation enables targeted fludrocortisone therapy, ensuring favorable growth and developmental outcomes.
Mian Muhammad Hassan Ahmed +4 more
wiley +1 more source
A Rare Neonatal Case of 48,XXYY Syndrome Presenting With Ambiguous Genitalia and Tetralogy of Fallot
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Neonatal 48,XXYY syndrome can present with both ambiguous genitalia and Tetralogy of Fallot, a striking and previously unreported association. This case broadens the phenotypic spectrum and underscores the importance of integrating genetic and cardiac evaluation in all neonates with disorders of sex development.
Nour Gazzaz
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.First Chinese neonatal cases of systemic PHA1B from novel compound‐heterozygous SCNN1B variants (c.585+2T>C; c.1544T>C) presented with life‐threatening hyperkalemia and hyponatremia unresponsive to steroids. Early genetic testing enabled targeted sodium supplementation and potassium‐binding therapy, normalizing electrolytes and underscoring SCNN1B ...
Zhiping Wang, Lijuan Long, Hongjuan Bi
wiley +1 more source
Experimental Biology and Medicine, 1970 SummaryIn the B6D2F1 mouse the MED by Hooker-Forbes bioassay of progesterone was 0.0005 μg; of 20α-hydroxyprogesterone, 0.0004 μg; of 20β-hydroxyprogesterone, 0.00006 μg; of 16α-hydroxyprogesterone, 2.0 μg. Progestin activity of mixtures of progesterone with 16α-hydroxyprogesterone, 20α-hydroxyprogesterone, and 20β-hydroxyprogesterone was measured by ...
openaire +1 more source