Results 11 to 20 of about 31,786 (211)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Contiguous Hydroxyproline Residues Direct Hydroxyproline Arabinosylation in Nicotiana tabacum [PDF]

Journal of Biological Chemistry, 2001
Hydroxyproline (Hyp) O-glycosylation characterizes the hydroxyproline-rich glycoprotein (HRGP) superfamily of the plant extracellular matrix. Hyp glycosylation occurs in two modes: Arabinosylation adds short oligoarabinosides (Hyp-arabinosides) while galactosylation leads to the addition of larger arabinogalactan polysaccharides (Hyp-polysaccharides ...
E, Shpak, E, Barbar, J F, Leykam, M J, Kieliszewski   +3 more
openaire   +2 more sources

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Does high-oxalate food cause oxalate stones? – Review of dietary factors affecting the risk of oxalate urolithiasis.

Medycyna Ogólna i Nauki o Zdrowiu, 2020
Introduction: Oxalate urolithiasis is the most common type of kidney stones, accounting for 70-80% of cases. Under certain conditions, such as: high oxalic acid concentration, high calcium levels, damaged tubular epithelium, urinary tract infections and ...
Małgorzata Kalemba-Drożdż
doaj   +1 more source

Pyridine 2,4-Dicarboxylic Acid Suppresses Tomato Seedling Growth

Frontiers in Chemistry, 2018
Pyridine 2,4-dicarboxylic acid is a structural analog of 2-oxoglutarate and is known to inhibit 2-oxoglutare-dependent dioxygenases. The effect of this inhibitor in tomato seedlings grown in MS media supplied with various concentrations of PDCA was ...
Sotirios Fragkostefanakis, Dimitrios Kaloudas, Panagiotis Kalaitzis   +2 more
doaj   +1 more source

Liver structure and fibrosis markers in modeling alcohol-induced liver injury and correction of detected disorders

Gastroenterologìa, 2023
Background. Chronic alcohol use leads to alcoholic liver fibrosis. Today, a sufficient number of scientific studies are focused on the pathometabolic mechanisms of liver fibrosis development and formation in animal models. The purpose of our study was to
V.I. Didenko, I.A. Klenina, O.I. Hrabovska, Yu.A. Gaidar, O.O. Halinskyi, V.A. Karachynova, D.F. Mylostуva   +6 more
doaj   +1 more source

Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

eLife, 2020
The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways.
Lindsey RF Backman, Yolanda Y Huang, Mary C Andorfer, Brian Gold, Ronald T Raines, Emily P Balskus, Catherine L Drennan   +6 more
doaj   +1 more source

Evaluation of the Healing Effects of Different Methods of Using Ozone in Third-Degree Skin Burns in Rat Experimental Model [PDF]

Iranian Journal of Veterinary Surgery
This study was conducted to evaluate the healing effects of different methods of using ozone in third-degree skin burns in the rat experimental model.
Yashar Rafiei, Seyed Mehdi Ghamsari, Farhang Sasani, Amir Ezzaty, Diba Golchin, Alireza Mohammadzadeh Akbari, Amirhossein Fallah   +6 more
doaj   +1 more source

Three Decades of Advances in Arabinogalactan-Protein Biosynthesis

Frontiers in Plant Science, 2020
Arabinogalactan-proteins (AGPs) are a large, complex, and highly diverse class of heavily glycosylated proteins that belong to the family of cell wall hydroxyproline-rich glycoproteins.
Jessy Silva, Jessy Silva, Ricardo Ferraz, Ricardo Ferraz, Paul Dupree, Allan M. Showalter, Sílvia Coimbra, Sílvia Coimbra   +7 more
doaj   +1 more source

Comparison of Follicular Fluid Glycosaminoglycan and Hydroxyproline Concentration in Women with Polycystic Ovary Syndrome with Healthy Women [PDF]

Avicenna Journal of Medical Biochemistry, 2023
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of childbearing age. As a complex structure, the extracellular matrix (ECM) and its components, including glycosaminoglycans (GAGs) and collagens, are highly
Kiana Kimiaei Asadi , Kimia Amiri, Hadi Ghasemi , Iraj Amiri   +3 more
doaj   +1 more source