Results 51 to 60 of about 31,786 (211)

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

open access: yesAdvanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng   +13 more
wiley   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

open access: yesAdvanced Science, EarlyView.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang   +9 more
wiley   +1 more source

Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics

open access: yesmAbs, 2019
Biotherapeutics may contain a multitude of different post-translational modifications (PTMs) that need to be assessed and possibly monitored and controlled to ensure reproducible product quality.
Oksana Tyshchuk   +13 more
doaj   +1 more source

Linezolid‐mediated Prevention of Fibroblast Activation and Tissue Fibrosis via Mitochondrial Translation Inhibition

open access: yesArthritis &Rheumatology, EarlyView.
Objective Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Because mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong   +13 more
wiley   +1 more source

Tissue‐specific and spatially dependent metabolic signatures perturbed by injury in male and female mice

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis—the leading cause of disability worldwide—disproportionately affects females, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven   +6 more
wiley   +1 more source

The role of undifferentiated connective tissue diseases in the development of ischemic-cervical insufficiency in pregnant women

open access: yesJournal of Education, Health and Sport, 2018
The article analyzes clinical and anamnestic and biochemical markers of undifferentiated connective tissue diseases (UCTDs), the course of pregnancy and childbirth in 56 women with ischemic-cervical insufficiency (ICI) and 30 healthy pregnancies without ...
O. M. Nosenko, Kamel Bakary
doaj  

Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus

open access: yesFrontiers in Pharmacology, 2018
Phyllanthus muellerianus (Family Euphorbiaceae) is a shrub, which is widely distributed in West Africa and employed traditionally as a wound-healing agent especially in Ghana.
Yaw D. Boakye   +5 more
doaj   +1 more source

Hydrogels Formed by the Self‐Assembly of Collagen‐Mimetic Peptides With a Constrained Backbone Structure

open access: yesChemistry – A European Journal, EarlyView.
Kinked collagen‐mimetic peptides (kinkCMPs), whose backbone is constrained by a disulfide bond, are designed to induce hydrogel formation. The kinked backbone promotes supramolecular assembly into tunable hydrogels with thermal stability depending on length.
Moeka Noto   +4 more
wiley   +1 more source

Chemical Ligation of Backbone N‐hydroxylated Peptides

open access: yesChemistry – A European Journal, EarlyView.
Peptide backbone N‐hydroxylation enables sequence‐agnostic fragment ligation via hydroxamate O‐acyl capture and O→N acyl transfer in water. Broad tolerance of sterically demanding nucleophilic residues is observed, and reductive N─O cleavage restores the native amide bond.
Natalia Cano‐Sampaio   +1 more
wiley   +1 more source

Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers

open access: yesIndian Journal of Plastic Surgery, 2014
Background: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. Materials and
Thittamaranahalli Muguregowda Honnegowda   +7 more
doaj   +1 more source

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