Results 41 to 50 of about 74,894 (279)

Hydroxyurea associated ileocecal valve ulcer: evidence for causality [PDF]

Intestinal Research, 2021
Hydroxyurea is an antimetabolite drug that is commonly used in many hematological disorders. Ulcer formation in the gastrointestinal tract is a rare phenomenon associated with this drug.
Thevaraajan Jayaraman, Ruveena Bhavani Rajaram, Gin Gin Gan, Ida Hilmi   +3 more
doaj   +1 more source

Changing the Clinical Paradigm of Hydroxyurea Treatment for Sickle Cell Anemia Through Precision Medicine

Clinical pharmacology and therapy, 2020
Sickle cell anemia (SCA) is a common and devastating inherited blood disorder, affecting millions of people across the world. Without treatment, SCA results in tremendous morbidity and early mortality. Hydroxyurea is the primary and most well‐established
M. Dong, Patrick T. McGann
semanticscholar   +1 more source

The properties of nerve cell precursors in hydra [PDF]

, 1986
Two signals, the head activator and an injury stimulus, control differentiation of nerve cells from uncommitted stem cells in hydra [Th. Holstein, H. C. Schaller, and C. N. David, (1986) Dev. Biol. 115, 9–17].
David, Charles N., Holstein, Thomas W.
core   +1 more source

The Current Role of Hydroxyurea in the Treatment of Sickle Cell Anemia

Journal of Clinical Medicine
Despite advancements in treatment of sickle cell disease (SCD), hydroxyurea, a ribonucleotide reductase inhibitor, remains the cornerstone of therapy. While its primary effect is the elevation of fetal hemoglobin (HbF), hydroxyurea’s mechanisms of action
Montserrat López Rubio, M. Argüello Marina   +1 more
semanticscholar   +1 more source

At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1 [PDF]

, 2014
Funding AS was supported by a Cancer Research UK PhD studentship and ORSAS. SK is supported by a Scottish Universities Life Sciences Alliance PhD studentship.
Donaldson, Anne D., Kedziora, Sylwia, Sridhar, Akila   +2 more
core   +4 more sources

Development of Myelodysplastic Syndrome and Acute Myeloid Leukemia 15 Years after Hydroxyurea Use in a patient with sickle Cell Anemia

Clinical Medicine Insights: Oncology, 2012
We report a 41 year old male with sickle cell disease who developed a myelodysplastic syndrome and acute myeloid leukemia with complex karyotype involving chromosomes 5, 7 and 17 after 15 years of hydroxyurea treatment.
Walid Baz, Vesna Najfeld, Matthew Yotsuya, Jotica Talwar, Terenig Terjanian, Frank Forte   +5 more
doaj   +1 more source

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells [PDF]

, 2010
Nucleotide excision repair (NER) is the most versatile DNA repair system that deals with the major UV photoproducts in DNA, as well as many other DNA adducts.
Cloney, Ross, Fousteri, Maria I, Japers, Nicolaas G, Lehmann, Alan R, Limsirichaikul, Siripan, Miki, Yoshio, Mullenders., Leon H F, Nakazawa, Yuka, Niimi, Atsuko, Ogi, Tomoo, Overmeer, René M, Takenaka, Katsuya, Volker, Marcel, Yamashita, Shunichi   +13 more
core   +3 more sources

Analysis of oxidative status and biochemical parameters in adult patients with sickle cell anemia treated with hydroxyurea, Ceará, Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: Sickle cell anemia is a hemoglobinopathy caused by a mutation that results in the production of an abnormal hemoglobin molecule, hemoglobin S (Hb S).
Paulo Florentino Teixeira Neto, Romélia Pinheiro Gonçalves, Darcielle Bruna Dias Elias, Cleiton Pinheiro de Araújo, Hemerson Iury Ferreira Magalhães   +4 more
doaj   +1 more source

Nitric Oxide Mediation in Hydroxyurea and Nitric Oxide Metabolites’ Inhibition of Erythroid Progenitor Growth

Biomolecules, 2021
In several systems, hydroxyurea has been shown to trigger nitric oxide (NO) release or activation of NO synthase (NOS). To elucidate this duality in its pharmacological effects, during myelosuppression, we individually examined hydroxyurea’s (NO ...
Tijana Subotički, Olivera Mitrović Ajtić, Dragoslava Djikić, Marijana Kovačić, Juan F. Santibanez, Milica Tošić, Vladan P. Čokić   +6 more
doaj   +1 more source

Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea [PDF]

, 1983
Previous work has shown that mammalian cells that carry unstably amplified genes for dihydrofolate reductase (DHFR) gradually lose the amplified DHFR genes when grown in the absence of the DHFR inhibitor methotrexate (MTX). Unstably amplified genes occur
Snapka, Robert M., Varshavsky, Alexander
core   +1 more source