Results 51 to 60 of about 74,894 (279)

MicroNIR/chemometrics assessement of occupational exposure to hydroxyurea [PDF]

, 2018
Portable Near Infrared spectroscopy (NIRs) coupled to chemometrics was investigated for the first time as a novel entirely on-site approach for occupational exposure monitoring in pharmaceutical field.
Materazzi, S., Risoluti, R.
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differences in HRQOL among Children with SCD Who Received Hydroxyurea and Those Who Did Not: A Quantitative Comparison Study

Oman Medical Journal
Objectives: Hydroxyurea is been recommended for patients with sickle cell disease (SCD) as it reduces the complications from the disease by increasing the production of fetal hemoglobin.
Yusra Al Nasiri, Amal Al Sabahi, Karima Al Hanai, Mohammed Al Hanai, Shah Mohammed Wasifuddin, Nawal Al Mashayki, Mudhar Al Adawi, Kamla Al Nassri, Salah Al Awaidy   +8 more
doaj   +1 more source

The dynamics of genome replication using deep sequencing [PDF]

, 2013
Peer reviewedPublisher ...
Agier, Alessandro P.S. de Moura, Alvino, Besnard, Bouton, Breier, Carolin A. Müller, Celniker, Chang, Conrad A. Nieduszynski, Cosgrove, Crampton, de Moura, De Piccoli, Di Rienzi, Eaton, Feng, Friedman, Gilbert, Hoggard, Huang, Katsuhiko Shirahige, Kearsey, Knott, Knott, Koren, Koren, Liachko, Lian, Makiko Komata, Martin J. Blythe, McGuffee, Mechali, Mechali, Mesner, Michelle Hawkins, Muller, Nakato, Natsume, Newman, Ng, Nieduszynski, Palzkill, Raghuraman, Ray Wilson, Renata Retkute, Retkute, Retkute, Rhind, Rudolph, Ryuichiro Nakato, Sekedat, Sharma, Shirahige, Siow, Sunir Malla, Theis, Theis, Theis, Vujcic, Xu, Xu, Yabuki, Yamashita, Yoshikawa   +64 more
core   +3 more sources

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source

Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia

American journal of hematology/oncology, 2019
Hydroxyurea is FDA‐approved and now increasingly used for children with sickle cell anemia (SCA), but dosing strategies, pharmacokinetic (PK) profiles, and treatment responses for individual patients are highly variable.
Patrick T. McGann, O. Niss, M. Dong, A. Marahatta, T. Howard, T. Mizuno, A. Lane, T. Kalfa, P. Malik, C. Quinn, R. Ware, A. Vinks   +11 more
semanticscholar   +1 more source

Computational study of radicals derived from hydroxyurea and its methylated analogues. [PDF]

, 2012
Structural and electronic properties and chemical fate of free radicals generated from hydroxyurea (HU) and its methylated analogues N-methylhydroxyurea (NMHU) and O-methylhydroxyurea (OMHU) are of utmost importance for their biological and ...
Birus, Mladen, Sakic, Davor, Vinkovic Vrcek, Ivana, Vrcek, Valerije, Zipse, Hendrik   +4 more
core   +1 more source

Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia

Trials, 2020
Background Sickle cell disease (SCD) is a severe and devastating hematological disorder that affects over 100,000 persons in the USA and millions worldwide.
Emily R. Meier, Susan E. Creary, Matthew M. Heeney, Min Dong, Abena O. Appiah-Kubi, Stephen C. Nelson, Omar Niss, Connie Piccone, Maa-Ohui Quarmyne, Charles T. Quinn, Kay L. Saving, John P. Scott, Ravi Talati, Teresa S. Latham, Amanda Pfeiffer, Lisa M. Shook, Alexander A. Vinks, Adam Lane, Patrick T. McGann   +18 more
doaj   +1 more source

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel, Vanessa Bellegarde, Stennio Da Silva Faria, Tristan St‐Laurent, Estelle Lecluze, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Frédéric Galactéros, Pablo Bartolucci, Marc‐André Legault, Guillaume Lettre, Thomas Pincez   +10 more
wiley   +1 more source

Engaging Caregivers and Providers of Children With Sickle Cell Anemia in Shared Decision Making for Hydroxyurea: Protocol for a Multicenter Randomized Controlled Trial

JMIR Research Protocols, 2021
BackgroundSickle cell anemia (SCA) is a genetic blood disorder that puts children at a risk of serious medical complications, early morbidity and mortality, and high health care utilization.
Hood, Anna M, Strong, Heather, Nwankwo, Cara, Johnson, Yolanda, Peugh, James, Mara, Constance A, Shook, Lisa M, Brinkman, William B, Real, Francis J, Klein, Melissa D, Hackworth, Rogelle, Badawy, Sherif M, Thompson, Alexis A, Raphael, Jean L, Yates, Amber M, Smith-Whitley, Kim, King, Allison A, Calhoun, Cecelia, Creary, Susan E, Piccone, Connie M, Hildenbrand, Aimee K, Reader, Steven K, Neumayr, Lynne, Meier, Emily R, Sobota, Amy E, Rana, Sohail, Britto, Maria, Saving, Kay L, Treadwell, Marsha, Quinn, Charles T, Ware, Russell E, Crosby, Lori E   +31 more
doaj   +1 more source