Results 71 to 80 of about 74,894 (279)

Nonmelanoma skin cancer associated with Hydroxyurea treatment: Overview of the literature and our own experience

Dermatologic Therapy, 2019
Nonmelanoma skin cancer is the most common malignant tumor in the fair skin population, with each year several millions of diagnosed cases. Their most common risk factors are fair skin, a history of excessive ultraviolet light exposure, chronic ...
C. Cantisani, N. Kiss, Ahmad Faiq Naqeshbandi, G. Tosti, S. Tofani, F. Cantoresi   +5 more
semanticscholar   +1 more source

Hydroxyurea-induced synchronisation of bloodstream stage Trypanosoma brucei [PDF]

, 2009
Synchronisation of the <i>Trypanosoma brucei</i> cell cycle proved elusive for many years. A recent report demonstrated that synchronisation of procyclic form cells was possible following treatment with hydroxyurea.
Forsythe, Glynn R., Hammarton, Tansy C., McCulloch, Richard   +2 more
core   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Impact of Xmn1 polymorphism on hydroxyurea therapy in children with HbE-β non-transfusion dependent thalassemia: a cohort study [PDF]

Clinical and Experimental Pediatrics
Background Fetal hemoglobin (HbF) inducers, among which hydroxyurea is the most extensively used, have shifted the paradigm toward the treatment of non–transfusion-dependent thalassemia (NTDT).
Saheli Roy, Paramita Bhattacharya, Atanu Kumar Dutta, Mrinal Kanti Das   +3 more
doaj   +1 more source

Hydroxyurea Use for Sickle Cell Disease Among Medicaid-Enrolled Children

Pediatrics, 2019
This population-based study of children with SCD assesses trends in hydroxyurea use and associated changes in ED visits and hospitalizations. BACKGROUND: Recent publications should have resulted in increased hydroxyurea usage in children with sickle cell
David C Brousseau, Troy Richardson, M. Hall, Angela M. Ellison, Samir S Shah, J. Raphael, D. Bundy, Staci D. Arnold   +7 more
semanticscholar   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Treatment comparison of hydroxyurea versus ruxolitinib in essential thrombocythaemia: A matched‐cohort analysis

eJHaem
Hydroxyurea is the preferred first‐line cytoreductive treatment for high‐risk essential thrombocythaemia (ET), but many patients are intolerant or refractory to hydroxyurea. Ruxolitinib has been shown to improve symptoms in patients with ET.
Michael R. Grunwald, Ellen K. Ritchie, Elisa Rumi, Albert Assad, J. E. Hamer‐Maansson, Jingbo Yu, Tricia Kalafut, Evan Braunstein, Francesco Passamonti   +8 more
doaj   +1 more source

An assessment of the frequency of blood transfusion before and after starting hydroxyurea therapy in children of sickle cell anemia

Asian Journal of Medical Sciences, 2022
Background: Hydroxyurea therapy is a known effective and safe therapy for the treatmentof sickle cell anemia (SCA). Although it is used worldwide in our Madhya Pradesh basedsetup, it is underutilized due to economic reasons and unaware practitioners ...
Shikha Gupta , Prachi Chaudhary , Amrita Chauhan , Preeti Malpani   +3 more
doaj   +1 more source

Hydroxyurea (hydroxycarbamide) for transfusion-dependent β-thalassaemia.

Cochrane Database of Systematic Reviews, 2019
BACKGROUND Hydroxyurea (hydroxycarbamide) promotes the production of foetal haemoglobin (HbF) by reactivating gamma-genes. Evidence has shown clinical benefits of hydroxyurea in people with sickle cell anemia; however, only a few studies have assessed ...
S. Ansari, Z. Lassi, S. Khowaja, Syed Omair Adil, T. Shamsi   +4 more
semanticscholar   +1 more source

Different response to epidermal growth factor of hepatocytes in cultures isolated from male or female rat liver. Inhibitor effect of estrogen on binding and mitogenic effect of epidermal growth factor [PDF]

, 1987
Deoxyribonucleic acid (DNA) synthesis in hepatocytes isolated from the livers of male and female rats has been compared in monolayer culture. Plating efficiency, DNA and protein content, viability, and morphologic appearance were the same in cultures ...
Coetzee, M, Francavilla, A, Kam, I, Ove, P, Pellici, R, Polimeno, L, Sciascia, C, Starzl, TE, Todo, S   +8 more
core   +1 more source