Results 121 to 130 of about 4,710,511 (291)
Advanced Science, EarlyView.After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma +12 more
wiley +1 more source
Hyper-Reduction Techniques for Efficient Simulation of Large-Scale Engineering Systems
Archives of Computational Methods in EngineeringAbstract Reduced-order models (ROMs) offer compact representations of complex engineering systems governed by partial differential equations or high-dimensional ordinary differential equations enabling efficient simulations of otherwise computationally intensive problems.
Suparno Bhattacharyya +3 more
openaire +1 more source
Advanced Science, EarlyView.A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon +12 more
wiley +1 more source
University of Chitral Journal of Linguistics and Literature, 2023 Since the 20th century, with the launch of natural language processing software, such as the Praat software in 1995, speech analysis has transcended subjective interpretations to scientific evaluations.
Mariam Titilope Olugbodi
doaj
Advanced Science, EarlyView.Large language models serve as representation generators for gradient‐free scientific optimization. Two complementary approaches produce executable battery‐charging policies either directly or through LLM‐designed neural representations coupled to Bayesian optimization.
Ge Lei +3 more
wiley +1 more source
, 2018 The Hyper-Kamiokande or Hyper-K, as a straightforward extension of the Super-Kamiokande, will provide major new capabilities to make new discoveries in particle and astroparticle physics thanks to an order of magnitude increase in detector mass and ...
Shiozawa, Masato +1 more
core +1 more source
An Expertise Transfer Framework For Autonomous Surgical Assistance
Advanced Science, EarlyView.This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao +12 more
wiley +1 more source
Advanced Science, EarlyView.PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue +4 more
wiley +1 more source
Data reduction based on hyper relations
, 1998 Data reduction makes datasets smaller but preserves classification structures of interest. In this paper we present a novel approach to data reduction based on lattice and hyper relations.
Hui Wang +5 more
core
Advanced Science, EarlyView.Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan +12 more
wiley +1 more source