Results 141 to 150 of about 65,627 (261)

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Meta-analysis of neural correlates of working memory, reward, and emotion processing in major depressive disorder using ALE. [PDF]

Psychol Med
Zhang Q, Hou Y, Ding H, Liu J.
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Unexpected remission of Darier disease in a melanoma patient treated with trametinib and naporafenib. [PDF]

JAAD Case Rep
Sboui K, Poulalhon N, Thomas L, Dalle S.
europepmc   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Neurotropic alphavirus infection induces PARP-1 hyperactivation-mediated energy collapse in motor neurons. [PDF]

J Virol
Williams RE, Pieterse L, Patel SS, McLaren MW, Elrick MJ, Griffin DE.   +5 more
europepmc   +1 more source

Posttraumatic stress, perceived hostile intention and reactions to peer provocation: A longitudinal study in US inner‐city youth

JCPP Advances, EarlyView.
This longitudinal study examined how posttraumatic stress (PTS) affects adolescents' responses to peer provocation, using self‐reports from 2014 predominantly ethnic minority youth aged 12–14. Path analysis showed that higher PTS was linked to more aggression, greater perceived hostility, and a lower tendency to ignore provocation, especially among ...
Vladislav Ruchkin, Andrew Stickley, Mary Schwab‐Stone, Johan Isaksson   +3 more
wiley   +1 more source

Neutrophil immunometabolism in ACLF and sepsis: mechanisms, dysfunction, and therapeutic opportunities. [PDF]

Front Immunol
Mukherjee S, Malemnganba T, Acharya P.
europepmc   +1 more source

Proactive therapeutic drug monitoring of infliximab leads to treatment durability in paediatric Crohn's disease: A single‐centre Australian experience

JPGN Reports, EarlyView.
Abstract Objectives To evaluate the durability and predictors of loss of response of infliximab (IFX) over 2 years in paediatric Crohn's disease (CD) utilizing a proactive therapeutic drug monitoring (TDM) strategy. Methods A retrospective, single‐centre cohort study was conducted at The Children's Hospital at Westmead (CHW), Australia, from January ...
Cher Wei Chuah, Jessica Eldredge, Annabel Magoffin, Edward Vincent O'Loughlin, Calvin Joomann Park, Juliana Puppi, Susan Siew, Michael Stormon, Kunal Thacker, Shoma Dutt   +9 more
wiley   +1 more source

Sustained soluble adenylyl cyclase (sAC)-generated cAMP is necessary and sufficient for hyperactivated motility in human sperm. [PDF]

Hum Reprod
Ritagliati C, Devine F, Buck J, Levin LR.   +3 more
europepmc   +1 more source