Results 101 to 110 of about 461,392 (302)
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
Individual classification of ADHD patients by integrating multiscale neuroimaging markers and advanced pattern recognition techniques [PDF]
, 2012 Accurate classification or prediction of the brain state across individual subject, i.e., healthy, or with brain disorders, is generally a more difficult task than merely finding group differences.
Jianfeng eFeng +5 more
core +2 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Revista Brasileira de Educação Especial, 2010 A Perturbação de Hiperatividade com Déficit de Atenção (PHDA) constitui uma perturbação com características desenvolvimentais de caráter crônico, que embora seja atenuada com o decorrer da idade, nomeadamente na sua componente hipercinética e impulsiva ...
Joaquim Ramalho
doaj +1 more source
Examination of a Parent-Assisted, Friendship-Building Program for Adolescents with ADHD [PDF]
, 2015 Attention-Deficit/Hyperactivity Disorder (ADHD) is a common childhood disorder that often contributes to impairment in multiple domains, including peer functioning.
Gardner, Denise Marie
core +2 more sources
Advanced Science, EarlyView.In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu +18 more
wiley +1 more source
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, EarlyView.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
Journal of Pediatric Research, 2017 Attention deficit and hyperactivity disorder (ADHD) is the most common childhood onset behavioral disorder characterized by a developmentally inappropriate attention deficit, hyperactivity-impulsivity or a combination of these.
Ceylan Çağıl Yetiş +1 more
doaj +1 more source
Advanced Science, EarlyView.An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu +11 more
wiley +1 more source
Gender differences in adolescents' academic motivation and classroom behaviour [PDF]
, 2013 © 2013 Taylor & Francis. The present study investigated gender differences in adolescents’ academic motivation and classroom behaviour and gender differences in the extent to which motivation was associated with, and predicted, classroom behaviour ...
Bugler, Myfanwy +2 more
core +1 more source