Results 81 to 90 of about 461,392 (302)

Leukodystrophy presenting as hyperactivity and bipolarity with uncommon adverse drug reaction

Indian Journal of Psychological Medicine, 2017
Leukodystrophy is a group of demyelinating neurodegenerative diseases of brain with varied presentation and multiple etiologies. Prognosis is predominantly dismal.
Roshan Sutar, Anirban Ray, Shekhar P Sheshadri   +2 more
doaj   +1 more source

Blockade of alpha 2-adrenergic receptors in prelimbic cortex: impact on cocaine self-administration in adult spontaneously hypertensive rats following adolescent atomoxetine treatment [PDF]

, 2017
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood ...
Baskin, Britahny M., Dhonnchadha, Brid A. Nic, Dwoskin, Linda P., Kantak, Kathleen M.   +3 more
core   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source

Clinical and neuropsychological profile in a sample of children with attention deficit hyperactivity disorders Perfil clínico e neuropsicológico de crianças com transtorno do deficit de atenção e hiperatividade

Arquivos de Neuro-Psiquiatria, 2008
The aim of this study was to evaluate clinical and neuropsychological findings in children with suspicion of attention deficity hyperactivity disorder (ADHD). The assessment involved 150 children aged 7 to 14 referred to NANI at UNIFESP.
Sueli Rizzutti, Elaine Girão Sinnes, Luzia Flavia Scaramuzza, Lívia Freitas, Denise Pinheiro, Sonia M. Palma, Claudia Berlim Mello, Monica Carolina Miranda, Orlando Francisco Amadeo Bueno, Mauro Muszkat   +9 more
doaj   +1 more source

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]

, 2015
Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P., Kantak, Kathleen M., Somkuwar, Sucharita S.   +2 more
core   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

The effects of cyber bullying or victimization behaviors on social reciprocity and online cognition of adolescents with attention-deficit/hyperactivity disorder

Psychiatry and Behavioral Sciences, 2020
Objective: Cyberbullying or its victimization reported previously at a higher rate within adolescents with attention-deficit/hyperactivity disorder (ADHD) might have related with their social reciprocity or online cognition deficits.
Rezzan Aydin Gorucu, Cihat Kagan Gurkan, Merve Canli, Hilal Tugba Kilic   +3 more
doaj   +1 more source

Methylphenidate treatment beyond adolescence maintains increased cocaine self-administration in the spontaneously hypertensive rat model of attention deficit/hyperactivity disorder [PDF]

, 2015
Past research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder showed that adolescent methylphenidate treatment enhanced cocaine abuse risk in SHR during adulthood.
Baskin, Britahny M., Dwoskin, Linda P., Kantak, Kathleen M.   +2 more
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Contrasting Effects of Oxytocin on MK801-Induced Social and Non-Social Behavior Impairment and Hyperactivity in a Genetic Rat Model of Schizophrenia-Linked Features

Brain Sciences
Social withdrawal in rodents is a measure of asociality, an important negative symptom of schizophrenia. The Roman high- (RHA) and low-avoidance (RLA) rat strains have been reported to exhibit differential profiles in schizophrenia-relevant behavioral ...
Daniel Sampedro-Viana, Toni Cañete, Paula Ancil-Gascón, Sonia Cisci, Adolf Tobeña, Alberto Fernández-Teruel   +5 more
doaj   +1 more source