Results 61 to 70 of about 461,392 (302)

Empirical tests of natural selection-based evolutionary accounts of ADHD : a systematic review [PDF]

, 2016
Objective ADHD is a prevalent and highly heritable mental disorder associated with significant impairment, morbidity and increased rates of mortality.
Barke, Edmund, Faraone, Stephen V, Ostergaard, Soren D, Thagaard, Marthe S   +3 more
core   +2 more sources

Cap‐oPMN: Oral Inflammatory Load Quantification Using Capillary Microfluidics and Automated Image Processing

Advanced Materials Technologies, EarlyView.
ABSTRACT Quantifying oral polymorphonuclear neutrophils (oPMNs) is a clinically validated approach for assessing periodontal inflammation. However, current methods, such as manual hemocytometry and flow cytometry, are time‐consuming (>3 h), require invasive sampling, and depend on staining and complex instrumentation, making them unsuitable for point ...
Mohsen Hassani, Azam Zare, Fatemeh Soheili, S. M. Mahdi H. Daneshvar, Mahdi Amrollahi Biouki, Yasaman Tahernezhad, Chunxiang Sun, Michael Glogauer, Ebrahim Ghafar‐Zadeh, Amir Sanati‐Nezhad   +9 more
wiley   +1 more source

Maternal genetic mutations as gestational and early life influences in producing psychiatric disease-like phenotypes in mice

Frontiers in Psychiatry, 2011
Risk factors for psychiatric disorders have traditionally been classified as genetic or environmental. Risk (candidate) genes, although typically possessing small effects, represent a clear starting point to elucidate downstream cellular/molecular ...
Georgia eGleason, Bojana eZupan, Miklos eToth   +2 more
doaj   +1 more source

Effect of Pycnogenol® on attention-deficit hyperactivity disorder (ADHD) : study protocol for a randomised controlled trial [PDF]

, 2017
Background: Methylphenidate (MPH), the first choice medication for attention-deficit hyperactivity disorder (ADHD), is associated with serious adverse effects like arrhythmia.
Ceulemans, Berten, De Bruyne, Tess, Hermans, Nina, Pieters, Luc, Savelkoul, Huub FJ, Van West, Dirk, Verhelst, Helene, Verlaet, Annelies AJ   +7 more
core   +2 more sources

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Effect of Psychostimulants on Distinct Attentional Parameters in Attentional Deficit/Hyperactivity Disorder

Biological Research, 2004
Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different ...
JAVIER LÓPEZ, VLADIMIR LÓPEZ, DANIEL ROJAS, XIMENA CARRASCO, PAULA ROTHHAMMER, RICARDO GARCÍA, FRANCISCO ROTHHAMMER, FRANCISCO ABOITIZ   +7 more
doaj  

Head Size and Cognition in Very Low Birth Weight (VLBW) Infants

Pediatric Neurology Briefs, 1991
The effect of VLBW ( < 1.5 kg) and subnormal head size at 8 months of age (corrected for prematurity) on neurocognitive abilities at school age was investigated by a longitudinal follow up of 249 children born between 1977 to 1979 and admitted to the ...
J Gordon Millichap
doaj   +1 more source

Deficient reinforcement learning in medial frontal cortex as a model of dopamine-related motivational deficits in ADHD [PDF]

, 2013
A
Barke, Edmund, Silvetti, Massimo, Verguts, Tom, Wiersema, Roeljan   +3 more
core   +2 more sources

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes

Frontiers in Cellular Neuroscience, 2020
IRSp53 (also known as BAIAP2) is an abundant excitatory postsynaptic scaffolding protein implicated in autism spectrum disorders (ASD), schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). IRSp53 is expressed in different cell types across
Yangsik Kim, Young Woo Noh, Kyungdeok Kim, Esther Yang, Hyun Kim, Eunjoon Kim, Eunjoon Kim   +6 more
doaj   +1 more source