Results 51 to 60 of about 219,244 (264)

Leukodystrophy presenting as hyperactivity and bipolarity with uncommon adverse drug reaction

Indian Journal of Psychological Medicine, 2017
Leukodystrophy is a group of demyelinating neurodegenerative diseases of brain with varied presentation and multiple etiologies. Prognosis is predominantly dismal.
Roshan Sutar, Anirban Ray, Shekhar P Sheshadri   +2 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Clinical and neuropsychological profile in a sample of children with attention deficit hyperactivity disorders Perfil clínico e neuropsicológico de crianças com transtorno do deficit de atenção e hiperatividade

Arquivos de Neuro-Psiquiatria, 2008
The aim of this study was to evaluate clinical and neuropsychological findings in children with suspicion of attention deficity hyperactivity disorder (ADHD). The assessment involved 150 children aged 7 to 14 referred to NANI at UNIFESP.
Sueli Rizzutti, Elaine Girão Sinnes, Luzia Flavia Scaramuzza, Lívia Freitas, Denise Pinheiro, Sonia M. Palma, Claudia Berlim Mello, Monica Carolina Miranda, Orlando Francisco Amadeo Bueno, Mauro Muszkat   +9 more
doaj   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

The effects of cyber bullying or victimization behaviors on social reciprocity and online cognition of adolescents with attention-deficit/hyperactivity disorder

Psychiatry and Behavioral Sciences, 2020
Objective: Cyberbullying or its victimization reported previously at a higher rate within adolescents with attention-deficit/hyperactivity disorder (ADHD) might have related with their social reciprocity or online cognition deficits.
Rezzan Aydin Gorucu, Cihat Kagan Gurkan, Merve Canli, Hilal Tugba Kilic   +3 more
doaj   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Contrasting Effects of Oxytocin on MK801-Induced Social and Non-Social Behavior Impairment and Hyperactivity in a Genetic Rat Model of Schizophrenia-Linked Features

Brain Sciences
Social withdrawal in rodents is a measure of asociality, an important negative symptom of schizophrenia. The Roman high- (RHA) and low-avoidance (RLA) rat strains have been reported to exhibit differential profiles in schizophrenia-relevant behavioral ...
Daniel Sampedro-Viana, Toni Cañete, Paula Ancil-Gascón, Sonia Cisci, Adolf Tobeña, Alberto Fernández-Teruel   +5 more
doaj   +1 more source

Contribuição dos fatores de risco psicossociais para o transtorno de déficit de atenção/hiperatividade Contribution of psychosocial risk factors for attention deficit/hyperactivity disorder

Arquivos de Neuro-Psiquiatria, 2005
OBJETIVO: Analisar a contribuição dos fatores psicossociais para a ocorrência do transtorno de déficit de atenção/hiperatividade (TDAH). MÉTODO: Este é um estudo retrospectivo de casos-controles que analisou 403 alunos de uma escola pública primária ...
Marcio M. Vasconcelos, Ana Flávia de A. Malheiros, Jairo Werner Jr., Adriana R. Brito, Jane Bardawil Barbosa, Ítalo S. Oliveira Santos, Daniel Fampa N. Lima   +6 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source