Results 51 to 60 of about 318,792 (292)

Maternal genetic mutations as gestational and early life influences in producing psychiatric disease-like phenotypes in mice

Frontiers in Psychiatry, 2011
Risk factors for psychiatric disorders have traditionally been classified as genetic or environmental. Risk (candidate) genes, although typically possessing small effects, represent a clear starting point to elucidate downstream cellular/molecular ...
Georgia eGleason, Bojana eZupan, Miklos eToth   +2 more
doaj   +1 more source

Programmable Pneumatic Actuator System for a Bioinspired Artificial Colon

Advanced Materials Technologies, EarlyView.
A modular soft robotic colon simulator driven by programmable pneumatic actuation is developed to mimic physiological and pathological‐like motility patterns of the large intestine. Finite element–guided design and distributed control enable anatomically realistic deformation for peristalsis, segmentation, and mass movements, supporting capsule ...
Andrew Bickerdike, Bo Tian, Xizheng Fang, Zepeng Wang, Yang Liu, Lucy Adams, Shyam Prasad   +6 more
wiley   +1 more source

Effect of Psychostimulants on Distinct Attentional Parameters in Attentional Deficit/Hyperactivity Disorder

Biological Research, 2004
Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different ...
JAVIER LÓPEZ, VLADIMIR LÓPEZ, DANIEL ROJAS, XIMENA CARRASCO, PAULA ROTHHAMMER, RICARDO GARCÍA, FRANCISCO ROTHHAMMER, FRANCISCO ABOITIZ   +7 more
doaj  

Head Size and Cognition in Very Low Birth Weight (VLBW) Infants

Pediatric Neurology Briefs, 1991
The effect of VLBW ( < 1.5 kg) and subnormal head size at 8 months of age (corrected for prematurity) on neurocognitive abilities at school age was investigated by a longitudinal follow up of 249 children born between 1977 to 1979 and admitted to the ...
J Gordon Millichap
doaj   +1 more source

IRSp53 Deletion in Glutamatergic and GABAergic Neurons and in Male and Female Mice Leads to Distinct Electrophysiological and Behavioral Phenotypes

Frontiers in Cellular Neuroscience, 2020
IRSp53 (also known as BAIAP2) is an abundant excitatory postsynaptic scaffolding protein implicated in autism spectrum disorders (ASD), schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). IRSp53 is expressed in different cell types across
Yangsik Kim, Young Woo Noh, Kyungdeok Kim, Esther Yang, Hyun Kim, Eunjoon Kim, Eunjoon Kim   +6 more
doaj   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Short-Term Orchestral Music Training Modulates Hyperactivity and Inhibitory Control in School-Age Children: A Longitudinal Behavioural Study

Frontiers in Psychology, 2019
Survey studies have shown that participating in music groups produces several benefits, such as discipline, cooperation and responsibility. Accordingly, recent longitudinal studies showed that orchestral music training has a positive impact on inhibitory
Maria C. Fasano, Cristina Semeraro, Rosalinda Cassibba, Morten L. Kringelbach, Morten L. Kringelbach, Morten L. Kringelbach, Lucia Monacis, Valeria de Palo, Peter Vuust, Elvira Brattico   +9 more
doaj   +1 more source

Prevalence and contributing factors to attention deficit hyperactivity disorder:a study of five- to fifteen-year-old children in Zhabei District, Shanghai [PDF]

, 2014
INTRODUCTION: This work aims to understand the features among 5- to 15-year-old children with attention deficit hyperactivity disorder (ADHD) in Zhabei District in Shanghai. METHODS: Children with ADHD were studied using general background questionnaire,
Coghill, David, Du, Y, Du, Yasong, Zhong, Xiangyang, Zhong, X, Jin, W, David, C, Jin, Wenlan   +7 more
core   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source