Results 21 to 30 of about 220,802 (263)

Sulfadiazine Plus Pyrimethamine Therapy Reversed Multiple Behavioral and Neurocognitive Changes in Long-Term Chronic Toxoplasmosis by Reducing Brain Cyst Load and Inflammation-Related Alterations

Frontiers in Immunology, 2022
Toxoplasma gondii infects one-third of the world population. For decades, it has been considered a silent lifelong infection. However, chronically T. gondii-infected persons may present psychiatric and neurocognitive changes as anxiety, depression, and ...
Barrios Leda Castaño, Andrea Alice Silva, Lina L Hernandez-Velasco, Ana Paula Da Silva Pinheiro, Daniel Gibaldi, José Roberto Mineo, Neide Maria Silva, Joseli Lannes-Vieira   +7 more
doaj   +1 more source

Gabapentin in Refractory Partial Seizures

Pediatric Neurology Briefs, 1996
The efficacy of gabapentin as an additional medication in 32 children with refractory partial seizures was studied at the Children’s Hospital, Boston, MA.
J Gordon Millichap
doaj   +1 more source

Disordered eating in anorexia nervosa: give me heat, not just food

Frontiers in Public Health
The recommendation to apply external heat to patients with anorexia nervosa (AN) was first documented by William Gull in 1874. Gull encountered this practice during his tenure as a consultant physician, responsible for issuing medical certifications for ...
Emilio Gutierrez, Emilio Gutierrez, Naomi García, Olaia Carrera, Olaia Carrera   +4 more
doaj   +1 more source

Hypothyroidism, Motor Clumsiness, and ADHD

Pediatric Neurology Briefs, 2001
The behavioral characteristics of 63 children with early-treated congenital hypothyroidism (CH) were evaluated by parent and teacher ratings and compared to 34 healthy controls (ages 7.5-9.5 yrs) at the University of Jyvaskyla, Finland.
J Gordon Millichap
doaj   +1 more source

Kluver-Bucy Syndrome after Meningoencephalitis

Pediatric Neurology Briefs, 2011
Researchers at Medical College of Georgia, Augusta, GA, report a 10-year-old girl with a history of Listeria monocytogenes meningoencephalitis, contracted at 2½ years of age, who developed behavioral changes consistent with Kluver-Bucy syndrome at 2 ...
J Gordon Millichap
doaj   +1 more source

Consensus Standards and Recommendations for Developmental and Cognitive Surveillance, Screening, and Evaluation in Sickle Cell Disease: Executive Summary From the National Alliance of Sickle Cell Centers Neurocognitive Workgroup

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz, Donna Murdaugh, Andrew M. Heitzer, Jennifer N. Longoria, Wendy Santos‐Modesitt, Arianna Martin, Judy Cavazos, Jeff Schatz, Catherine R. Hoyt, Alison King, Eboni I. Lance, Steven Hardy, Marsha Treadwell   +12 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review

Frontiers in Nutrition, 2019
Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Martha A. Schalla, Andreas Stengel, Andreas Stengel   +2 more
doaj   +1 more source