Results 81 to 90 of about 456,784 (284)

Attention-deficit/hyperactivity disorder medication and seizures [PDF]

open access: yes, 2018
OBJECTIVE: Individuals with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of seizures, but there is uncertainty about whether ADHD medication treatment increases risk among patients with and without preexisting seizures ...
Brikell, Isabell   +8 more
core   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

open access: yesAdvanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son   +2 more
wiley   +1 more source

State-related electroencephalographic deviances in attention deficit hyperactivity disorder [PDF]

open access: yes, 2006
The dynamic security region (DSR) of bulk power system has been accepted more and more in recent years for providing plenty of security information and good prospect in online application.
Inez Buyck   +74 more
core   +3 more sources

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao   +11 more
wiley   +1 more source

Leukodystrophy presenting as hyperactivity and bipolarity with uncommon adverse drug reaction

open access: yesIndian Journal of Psychological Medicine, 2017
Leukodystrophy is a group of demyelinating neurodegenerative diseases of brain with varied presentation and multiple etiologies. Prognosis is predominantly dismal.
Roshan Sutar   +2 more
doaj   +1 more source

Out of Sight, Out of Mind/Out of Mind, Out of Site: Schooling and Attention Deficit Hyperactivity Disorder [PDF]

open access: yes, 2006
Attention Deficit Hyperactivity Disorder is a diagnostic term now indelibly scored on the public psyche. It is one of the most widely researched topics in the world today. In some quarters, a diagnosis of "ADHD" is regarded with derision.
Graham, Linda
core   +3 more sources

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

open access: yesAdvanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang   +6 more
wiley   +1 more source

Clinical and neuropsychological profile in a sample of children with attention deficit hyperactivity disorders Perfil clínico e neuropsicológico de crianças com transtorno do deficit de atenção e hiperatividade

open access: yesArquivos de Neuro-Psiquiatria, 2008
The aim of this study was to evaluate clinical and neuropsychological findings in children with suspicion of attention deficity hyperactivity disorder (ADHD). The assessment involved 150 children aged 7 to 14 referred to NANI at UNIFESP.
Sueli Rizzutti   +9 more
doaj   +1 more source

Behavioural outcomes and psychopathology during adolescence [PDF]

open access: yes, 2013
Preterm birth is associated with a high risk of residual neurodevelopmental disability and cognitive impairment. These problems are closely associated with psychiatric disorders and thus it is unsurprising that preterm birth also confers high risk for ...
Johnson, Samantha J., Wolke, Dieter
core   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

open access: yesAdvanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu   +20 more
wiley   +1 more source

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