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Medical Clinics of North America, 1988
Primary hyperaldosteronism is a challenging diagnosis because of its low incidence and variable pathophysiology. Serum potassium, properly done, is the routine screening test, but is not without its limitations. Confirmation of the diagnosis requires demonstration of abnormally high and nonsuppressible values for aldosterone in plasma and urine and low
R H, Noth, E G, Biglieri
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Primary hyperaldosteronism is a challenging diagnosis because of its low incidence and variable pathophysiology. Serum potassium, properly done, is the routine screening test, but is not without its limitations. Confirmation of the diagnosis requires demonstration of abnormally high and nonsuppressible values for aldosterone in plasma and urine and low
R H, Noth, E G, Biglieri
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Experimental and Clinical Endocrinology & Diabetes, 2002
Primary hyperaldosteronism (PHA) is regarded as a rare disease with prevalence rates of 0.5 to 2% within the hypertensive population. Recent studies using more detailed screening procedures in small hypertensive cohorts have suggested that PHA may be more common than previously thought (3-18%).
M, Quinkler, J, Lepenies, S, Diederich
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Primary hyperaldosteronism (PHA) is regarded as a rare disease with prevalence rates of 0.5 to 2% within the hypertensive population. Recent studies using more detailed screening procedures in small hypertensive cohorts have suggested that PHA may be more common than previously thought (3-18%).
M, Quinkler, J, Lepenies, S, Diederich
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Diagnosis of Hyperaldosteronism
Endocrinology and Metabolism Clinics of North America, 1991Hyperaldosteronism is associated with hypertension, potassium depletion, and suppressed plasma renin activity. It may involve one or both adrenal glands. This article reviews the different types of hyperaldosteronism and the diagnosis and management of each.
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Primary hyperaldosteronism in pregnancy
American Journal of Obstetrics and Gynecology, 1986A case is reported of a primigravid woman presenting in midgestation with severe hypertension caused by primary hyperaldosteronism. Symptomatic treatment with an aldosterone blocker, a peripheral vasodilator, and a combined alpha beta-blocker allowed pregnancy to continue to 36 weeks' gestation.
F K, Lotgering +2 more
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Neurodegenerative disorders and hyperaldosteronism
The Journal of Pediatrics, 1971Elevated plasma renin (3 patients) and aldosterone secretion rates (4 patients) have been found in patients with the syndrome of “ophthalmoplegia plus.” Autopsy in one of the patients revealed subacute necrotizing encephalopathy, hyperplasia of the juxtaglomerular apparatus, and nodular hyperplasia of the zona glomerulosa of the adrenal gland. Three of
A P, Simopoulos +2 more
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Dexamethasone-Suppressible Hyperaldosteronism
The Journal of Clinical Endocrinology & Metabolism, 1973Reinvestigation of an 18-yr-old male patient with dexamethasone-suppressible hyperaldosteronism after 6 yr of little or no treatment demonstrates that elevated blood pressure and increased urinary aldosterone excretion still were promptly decreased by a small dose of dexamethasone.
M I, New, E J, Siegal, R E, Peterson
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THE DIAGNOSIS OF PRIMARY HYPERALDOSTERONISM
The Lancet, 1981An aldosterone-suppression test based on a simple method of extracellular-fluid volume expansion over three days reliably discriminated between patients with aldosterone-producing adenomas, idiopathic adrenal hyperplasia, and essential benign hypertension.
N J, Vaughan +6 more
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Surgery for Primary Hyperaldosteronism
Urologic Clinics of North America, 1989The most common underlying disorder in primary aldosteronism is a benign unilateral adenoma. Some cases, termed idiopathic, are secondary to bilateral adrenal hyperplasia, and a few are caused by adrenocortical carcinoma. The therapeutic alternatives are pharmacologic management with an aldosterone antagonist and surgical adrenalectomy.
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