Results 221 to 230 of about 104,030 (296)

Trans-Chalcone alleviates overt pain-like behavior by targeting the activation of nociceptive neuron TRPV1 and TRPA1 channels. [PDF]

Inflammopharmacology
Piva M, Yaekashi KM, Pereira TGO, Bertozzi MM, Pinho-Ribeiro FA, Calixto-Campos C, Camilios-Neto D, Borghi SM, Zarpelon-Schutz AC, Fattori V, Casagrande R, Verri WA.   +11 more
europepmc   +1 more source

Mechanisms of Remifentanil-Induced Postoperative Hyperalgesia: A Comprehensive Review. [PDF]

Drug Des Devel Ther
Zhu K, Wen X, Mei X, Fang F, Zhang T.
europepmc   +1 more source

Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy - mechanisms, challenges, and emerging therapeutics. [PDF]

World J Diabetes
Khalid N, Shafin N, Long I, Hasim H, Ismail CAN.   +4 more
europepmc   +1 more source

Mitochondrial dysfunction at the intersection of alcohol use disorder and chronic pain. [PDF]

Function (Oxf)
Chapa-Dubocq XR, Edwards S.
europepmc   +1 more source

Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia

Lancet, The, 2019
Opioids are a mainstay of acute pain management but can have many adverse effects, contributing to problematic long-term use. Opioid tolerance (increased dose needed for analgesia) and opioid-induced hyperalgesia (paradoxical increase in pain with opioid
Lesley A Colvin, Fiona Bull, Tim G Hales
exaly   +2 more sources

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

Nature Neuroscience, 2013
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing treatment with morphine resulted in downregulation of the K+-Cl− co ...
Francesco Ferrini, Tuan Trang, Sophie Laffray   +2 more
exaly   +2 more sources

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Models and Mechanisms of Hyperalgesia and Allodynia

Physiological Reviews, 2009
Jürgen Sandkühler
exaly   +2 more sources

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

Lancet Neurology, The, 2014
Troels S Jensen
exaly   +2 more sources

Opioid hyperalgesia

Current Opinion in Supportive & Palliative Care, 2010
Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
openaire   +2 more sources