Results 201 to 210 of about 16,227 (258)
British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan +3 more
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European Journal of Neurology, Volume 33, Issue 9, September 2026.ABSTRACT Background Neurological and psychiatric disorders pose a persistent global health burden, with conventional therapies often providing inadequate relief. Transcranial ultrasound stimulation (TUS) has attracted considerable attention as a non‐invasive neuromodulation technique offering high spatial resolution and the distinctive capacity to ...
Yunjie Sui +3 more
wiley +1 more source
Factors Associated With Endodontic Flare‐Ups: A Systematic Review and Meta‐Analysis
International Endodontic Journal, Volume 59, Issue 9, Page 1778-1791, September 2026.ABSTRACT Background Endodontic flare‐ups, characterized by severe postoperative pain and/or swelling requiring unscheduled intervention, remain a clinically significant concern in root canal therapy. Identifying the factors associated with flare‐ups is important for anticipating and managing patient outcomes.
Jun Ohshima +8 more
wiley +1 more source
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Current Opinion in Supportive & Palliative Care, 2010
Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
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Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
openaire +2 more sources
Journal of PeriAnesthesia Nursing, 2012
HYPERALGESIAMEANS INCREASED sensitivity to pain. Opioid-induced hyperalgesia (OIH) is a paradoxical situation in which increasing doses of opioid result in increasing sensitivity to pain. OIH has been identified as a clinical reality, but the incidence of clinically significant OIH is unknown.
Chris, Pasero, Margo, McCaffery
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HYPERALGESIAMEANS INCREASED sensitivity to pain. Opioid-induced hyperalgesia (OIH) is a paradoxical situation in which increasing doses of opioid result in increasing sensitivity to pain. OIH has been identified as a clinical reality, but the incidence of clinically significant OIH is unknown.
Chris, Pasero, Margo, McCaffery
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Opioid Tolerance and Hyperalgesia
Medical Clinics of North America, 2007Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain.
Grace, Chang, Lucy, Chen, Jianren, Mao
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Journal of Musculoskeletal Pain, 2002
SUMMARYObjectives: The aim of this paper is to give a brief introduction to the mechanisms and manifestations related to muscle hyperalgesia. It has become increasingly evident that muscle hyperalgesia plays an important role in chronic musculoskeletal pain.
Arendt-Nielsen, Lars +1 more
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SUMMARYObjectives: The aim of this paper is to give a brief introduction to the mechanisms and manifestations related to muscle hyperalgesia. It has become increasingly evident that muscle hyperalgesia plays an important role in chronic musculoskeletal pain.
Arendt-Nielsen, Lars +1 more
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Hyperalgesia and opioid switching
American Journal of Hospice and Palliative Medicine®, 2005Opioids, intended to abolish pain, can unexpectedly produce hyperalgesia, particularly during rapid opioid escalation. Opioid switching could be a therapeutic option in a condition of opioid-induced tolerance or hyperalgesia, but conversion ratios between opioids are difficult to apply in this context and require strict surveillance and expertise.
Sebastiano, Mercadante, Edoardo, Arcuri
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Spinal Mediators of Hyperalgesia
Drugs, 1994Neuronal plasticity associated with altered sensations arising from tissue damage involves both established (e.g. substance P and excitatory amino acids) and novel (e.g. nitric oxide and metabolites of arachidonic acid) mediators released from terminals of primary afferent neurons or synthesised in the spinal cord.
S T, Meller, G F, Gebhart
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Kinins and their receptors in hyperalgesia
Canadian Journal of Physiology and Pharmacology, 1997Kinins (bradykinin, kallidin) are produced at sites of injury and inflammation and serve a critical role in signaling tissue distress as well as organising tissue responsiveness to injury. The acute activation and prolonged sensitization of fine afferents, to produce pain and hyperalgesia, are important in the protective responses that occur to ...
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