Results 191 to 200 of about 16,227 (258)

The rs10781468 Genetic Polymorphism of the Gαq (GNAQ) Gene Is Associated With Responsiveness to Opioid Analgesics in Patients With Postoperative and Cancer Pain: An Exploratory Study

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
In our exploratory hypothesis‐generating study using patients with postoperative pain and cancer pain, for rs10781468 in the GNAQ gene, the minor allele was associated with reduced opioid consumption and an increased pain threshold. ABSTRACT Background G protein–coupled receptors, the largest class of cell surface receptors, are ubiquitously expressed ...
Hiroaki Owada, Daisuke Nishizawa, Tsutomu Mieda, Miki Tsujita, Hideyuki Nakagawa, Shigeki Yamaguchi, Rikuhei Tsuchida, Yaeko Yokoshima, Akira Kitamura, Masakazu Hayashida, Ken‐ichi Fukuda, Tatsuya Ichinohe, Kazutaka Ikeda, Makoto Kurano, Masahiko Sumitani, Kanji Uchida   +15 more
wiley   +1 more source

Plasma Lidocaine Concentrations During Intravenous Lidocaine Infusion Therapy in the Pediatric Population—A Scoping Review

Pediatric Anesthesia, Volume 36, Issue 9, Page 1041-1051, September 2026.
ABSTRACT Background Intravenous lidocaine therapy (IVLT) is often used in perioperative multimodal analgesia due to its analgesic, anti‐hyperalgesic, and anti‐inflammatory effects. In adults, IVLT doses of 1–2 mg/kg/h produce plasma concentrations of 1–2 μg/mL, within the presumed therapeutic range of 1–5 μg/mL.
McKenna Postles, Amanda Barton, Nicholas West, Gillian Lauder   +3 more
wiley   +1 more source

“Google It”: Experiences of Children and Parents During the Assessment and Diagnosis of Complex Regional Pain Syndrome Type I

Paediatric and Neonatal Pain, Volume 8, Issue 3, September 2026.
ABSTRACT Complex Regional Pain Syndrome Type I (CRPS‐I) is a chronic pain disorder that can affect children most commonly in early adolescence. In comparison to adult literature, there is a sparsity of evidence regarding the effect of CRPS‐I on children.
Emma Evans, Lisa Roberts, Rhiannon Joslin   +2 more
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, Volume 2, Issue 3, September 2026.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Phenotyping Increased Urge to Defecate in Irritable Bowel Syndrome: Analysis of Symptom, Sensory, and Psychological Profiles

United European Gastroenterology Journal, Volume 14, Issue 7, September 2026.
ABSTRACT Introduction Visceral hypersensitivity (VHS) is considered a hallmark of irritable bowel syndrome (IBS) characterized by altered thresholds for rectal pain and discomfort during rectal distention. Rectal distention can also elicit the urge to defecate, a normal physical sensation that is, reported more often in IBS and may involve mechanisms ...
Sylvester R. Groen, Lisa Vork, Zsa Zsa R. M. Weerts, Zlatan Mujagić, José M. Conchillo, Ad A. M. Masclee, Daisy M. A. E. Jonkers, Daniel Keszthelyi   +7 more
wiley   +1 more source

Molecular and Immunohistochemical Analyses of PLIN4 in the Spinal Cord and Brain During the Development of Electroacupuncture‐Induced Analgesic Tolerance in Mice

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Repeated electroacupuncture induced analgesic tolerance and increased Plin4 expression, particularly in spinal dorsal horn neurons. Intrathecal Plin4 knockdown delayed tolerance development and increased pain threshold, while Plin4 expression was positively associated with lipid droplet formation in N2a cells. ABSTRACT Background Electroacupuncture (EA)
Shao‐Jia Jiang, Shi‐Ya Cao, Ming‐Fei Fan, Hao Li, Rui‐Ling Yin, Qiang‐Hui Lei, Sha Nan, Hao‐Long Wang, Zi‐Hui Cai, Ya‐Ya Jiao, Fei Huang, Yi Ding, Xiao‐Shu Zhou, Xin‐Yue Chai   +13 more
wiley   +1 more source

DN4‐Positive Neuropathic Pain Features in End‐Stage Knee Osteoarthritis Awaiting Arthroplasty: Prevalence and Relationship With Function and Quality‐of‐Life

International Journal of Rheumatic Diseases, Volume 29, Issue 9, September 2026.
ABSTRACT Objectives This cross‐sectional study investigated the occurrence of neuropathic pain features (NP) in individuals with end‐stage knee osteoarthritis (KOA) referred to total knee arthroplasty (TKA) and explored its association with functional and quality‐of‐life outcomes. Methods In 902 patients, NP was screened using the Douleur Neuropathique
Alan P. Mozella, Ana Carolina Leal, Rafael Erthal de Paula, Aline Cordeiro Fernandes Ladeira, Sandra Minamoto, Matheus Carvalho, Jordanna Franco Sucupira, Ricardo Kobayashi, Thiago Lemos   +8 more
wiley   +1 more source

Management of Pain in the Intensive Care Unit: A Nordic Survey

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Pain is common in intensive care unit (ICU) patients with up to one‐third experiencing pain at rest and even more during mobilization and clinical procedures. This survey aimed to explore physicians' attitudes and preferences regarding pain management in adult ICU patients in the Nordic countries.
Benedikte Kollerup Madsen, Morten Hylander Møller, Stine Estrup, Lone Musaeus Poulsen, Bodil Steen Rasmussen, Kirstine Sylvester Conradsen, Thomas Lass Klitgaard, Asger Granfeldt, Theis Skovsgaard Itenov, Hans Christian Thorsen Meyer, Signe Tellerup Nielsen, Susanne Andi Iversen, Klaus Tjelle Kristiansen, Morten Heiberg Bestle, Kirsten Møller, Peter Hasse Møller Sørensen, Jeppe Veien Nygaard, Kristian Elgaard, Morten Rune Blichfeldt‐Eckhardt, Ann Christine Waarkjær Olsen, Mette Pedersen, Henrik Westy Hoffmeyer, Peter Martin Hansen, Helle Bundgaard, Marcus Ølgaard Møller, Jarl Sigaard, Kim Zillo Rokamp, Anne Craveiro Brøchner, Christoffer Sølling, Mika Valtonen, Anna‐Maria Kuivalainen, Annukka Vahtera, Stepani Bendel, Martin I. Sigurdsson, Per Martin Bådstøløkken, Fredrik Sjövall, Ole Mathiesen, Lars Peter Kloster Andersen   +37 more
wiley   +1 more source

Rebound Pain and Patient Satisfaction With Dexamethasone as an Adjunct for Peripheral Nerve Blocks. A Substudy Based on Two Randomised Clinical Trials

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Peripheral nerve blocks (PNBs) are a cornerstone in postoperative pain management, reducing pain, opioid consumption, and opioid‐related adverse effects. However, the duration of PNBs is limited and might result in rebound pain after block cessation.
Laura B. Madsen, Jakob H. Andersen, Anders K. Nørskov, Janus C. Jakobsen, Ole Mathiesen, Mathias Maagaard   +5 more
wiley   +1 more source

TRPA1 Regulates Fibrosis‐Associated Transcriptional Pathways in Human Lung Epithelial Cells

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Leevi Halonen, Samu Luostarinen, Ida Valjus, Julia Vistbacka, Antti Pemmari, Eeva Moilanen   +5 more
wiley   +1 more source