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Rapid peripheral reprogramming of myelinated afferents drives human hyperalgesia
Bouchatta O +16 more
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Current Opinion in Supportive & Palliative Care, 2010
Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
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Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
openaire +2 more sources
Journal of PeriAnesthesia Nursing, 2012
HYPERALGESIAMEANS INCREASED sensitivity to pain. Opioid-induced hyperalgesia (OIH) is a paradoxical situation in which increasing doses of opioid result in increasing sensitivity to pain. OIH has been identified as a clinical reality, but the incidence of clinically significant OIH is unknown.
Chris, Pasero, Margo, McCaffery
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HYPERALGESIAMEANS INCREASED sensitivity to pain. Opioid-induced hyperalgesia (OIH) is a paradoxical situation in which increasing doses of opioid result in increasing sensitivity to pain. OIH has been identified as a clinical reality, but the incidence of clinically significant OIH is unknown.
Chris, Pasero, Margo, McCaffery
openaire +4 more sources
Opioid Tolerance and Hyperalgesia
Medical Clinics of North America, 2007Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain.
Grace, Chang, Lucy, Chen, Jianren, Mao
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Journal of Musculoskeletal Pain, 2002
SUMMARYObjectives: The aim of this paper is to give a brief introduction to the mechanisms and manifestations related to muscle hyperalgesia. It has become increasingly evident that muscle hyperalgesia plays an important role in chronic musculoskeletal pain.
Arendt-Nielsen, Lars +1 more
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SUMMARYObjectives: The aim of this paper is to give a brief introduction to the mechanisms and manifestations related to muscle hyperalgesia. It has become increasingly evident that muscle hyperalgesia plays an important role in chronic musculoskeletal pain.
Arendt-Nielsen, Lars +1 more
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Spinal Mediators of Hyperalgesia
Drugs, 1994Neuronal plasticity associated with altered sensations arising from tissue damage involves both established (e.g. substance P and excitatory amino acids) and novel (e.g. nitric oxide and metabolites of arachidonic acid) mediators released from terminals of primary afferent neurons or synthesised in the spinal cord.
S T, Meller, G F, Gebhart
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