Results 161 to 170 of about 16,227 (258)

Individual Differences in Secondary Hyperalgesia and Associated Neural Activity [PDF]

Chronic pain is a leading cause of disability, yet it remains difficult to treat due to our limited understanding of its underlying mechanisms (Nijs et al., 2021).
Millar, Kayla Ann
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Acute Pain During Intensive Care: Prevalence, Predisposing Factors and Pain Trajectories. A Prospective Multicenter Observational Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background A considerable proportion of patients in the intensive care unit (ICU) experience pain. The objective of this prospective observational cohort study was to investigate the prevalence of pain, factors associated with pain and pain trajectories in ICU patients.
Aleksandra E. Wlodarczyk‐Abou Elseoud, Maija‐Liisa Kalliomäki, Otto Mäkinen, Annika Laukkanen, Minna Bäcklund, Mitja Lääperi, Katri Hamunen, Anna‐Maria Kuivalainen   +7 more
wiley   +1 more source

TGF‐β1 Directly Sensitizes Capsaicin‐Sensitive Lung Vagal Neurons to Promote Airway Hypersensitivity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Transforming growth factor‐β1 (TGF‐β1) is a pleiotropic cytokine implicated in the pathogenesis of inflammatory airway diseases such as asthma. Airway hypersensitivity (AHS), arising from sensitization of capsaicin‐sensitive lung vagal (CSLV) afferents, is a hallmark of these airway diseases.
Yueh‐Yin Chen, Nai‐Ju Chan, Chun‐Chun Hsu   +2 more
wiley   +1 more source

Mechanism of hyperalgesia following cutaneous inflammation by Complete Freund Adjuvant.

, 2000
BACKGROUND: After an injury to tissue such as the skin, hyperalgesia develops. Hyperalgesia is characterized by an increase in the magnitude of pain evoked by noxious stimuli.
임중우, 남택상
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The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

A TRIP‐nano killer silencing the pain pacemakers

The Journal of Physiology, EarlyView.
Elisabetta Cerbai
wiley   +1 more source

The Use of Extended Reality Distraction Methods During Needle‐Related Procedures in Pediatric Hospital Care—Children's Experiences

Journal for Specialists in Pediatric Nursing, Volume 31, Issue 4, October 2026.
ABSTRACT Purpose To describe children's experiences of using extended reality (XR) distraction, namely virtual reality (VR) and augmented reality (AR), during needle‐related procedures. Design and Methods An exploratory, prospective convergent parallel mixed‐methods design was employed.
Anna Stålberg, Johanna Granhagen Jungner, Cecilia Bartholdson, Henrik Hjelmgren   +3 more
wiley   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, Volume 13, Issue 51, 14 September 2026.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, Volume 13, Issue 54, 28 September 2026.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source