Results 181 to 190 of about 16,227 (258)
ABSTRACT Background Pain perception is the result of different modulatory mechanisms. Inhibition, via descending brainstem mechanisms, is key to pain reduction and is typically elicited by the cold pressor test (CPT). Recently, a compensatory hedonic response has been observed after CPT interruption, thought to facilitate return to homeostasis ...
Matthieu Vincenot +3 more
wiley +1 more source
ABSTRACT Background Low back pain (LBP) is the leading cause of years lived with disability. While education is recommended by most guidelines, the type of language used can lead to a placebo or nocebo effect. This study aims to compare the short‐term effect of negative language versus positive language on physical and functional capacity in ...
Yves Schwendenmann +3 more
wiley +1 more source
ABSTRACT Background and Objectives Multiple sclerosis (MS) is a neurodegenerative disorder frequently leading to neuropathic pain. Due to the neurodegenerative nature, the diagnosis of neuropathic pain remains challenging. A grading system has been developed providing an overview of diagnostic certainty (i.e., possible, probable and definite). Since no
Rasmus C. Jungersen +4 more
wiley +1 more source
ABSTRACT Background A substantial proportion of people with fibromyalgia also experience comorbid disorders of gut–brain interaction (DGBIs), which can lead to considerable personal and societal burdens. However, evidence regarding the implications of this comorbidity remains limited.
Lin Yu +3 more
wiley +1 more source
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios +7 more
wiley +1 more source
Stem cell‐derived exosomes offer a promising cell‐free therapy for spinal cord injury by delivering diverse bioactive cargos. This review highlights their roles in motor recovery, sensory restoration, and neuropathic pain relief through axonal regeneration, synaptic remodeling, neural differentiation, glial metabolic reprogramming, immunomodulation ...
Md Miftahul Mithu +8 more
wiley +1 more source
Neuromorphic hardware enables the integration of sensing, memory, and computing for intelligent artificial perception. Recent advances in multimodal fusion further highlight its potential for embodied intelligence and next‐generation human–machine interfaces.
Yixin Zhu +3 more
wiley +1 more source
Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry
This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie +7 more
wiley +1 more source
ABSTRACT Objective This study aimed to examine the acceptability, usability, patient perceptions and preliminary effects of a virtual reality (VR) based pain management programme for people with rheumatoid arthritis with persistent pain despite low disease activity.
Stijn J. M. Temmink +7 more
wiley +1 more source

