Results 181 to 190 of about 44,701 (229)
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Hyperalgesia and opioid switching
American Journal of Hospice and Palliative Medicine®, 2005Opioids, intended to abolish pain, can unexpectedly produce hyperalgesia, particularly during rapid opioid escalation. Opioid switching could be a therapeutic option in a condition of opioid-induced tolerance or hyperalgesia, but conversion ratios between opioids are difficult to apply in this context and require strict surveillance and expertise.
Sebastiano, Mercadante, Edoardo, Arcuri
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Kinins and their receptors in hyperalgesia
Canadian Journal of Physiology and Pharmacology, 1997Kinins (bradykinin, kallidin) are produced at sites of injury and inflammation and serve a critical role in signaling tissue distress as well as organising tissue responsiveness to injury. The acute activation and prolonged sensitization of fine afferents, to produce pain and hyperalgesia, are important in the protective responses that occur to ...
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Synaptic mechanisms of hyperalgesia
2000Publisher Summary Hyperalgesia and allodynia often aggravate pain for variable periods after trauma, surgery, and inflammation. Pain that is induced by normally nonpainful stimuli (allodynia) or abnormally intense pain elicited by noxious stimuli (hyperalgesia) may be the consequence of an increased sensitivity of nociceptors (peripheral ...
J, Sandkühler +4 more
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G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia
Journal of Molecular Neuroscience, 2017Tissue injury, pathogen infection, and diseases are often accompanied by inflammation to release mediators that sensitize nociceptors and further recruit immune cells, which can lead to chronic hyperalgesia and inflammation. Tissue acidosis, occurring at the inflammatory site, is a major factor contributing to pain and hyperalgesia.
Yeu-Shiuan Su +5 more
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Neural mechanisms of hyperalgesia
Current Opinion in Neurobiology, 1992Hyperalgesia, or enhanced sensitivity to pain, is a symptom often associated with inflammation, nerve injury and various diseases. Although hyperalgesia appears to be mediated by sensitization of peripheral and central pain-signalling neurons, underlying mechanisms of sensitization are not well understood.
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Ethanol Withdrawal and Hyperalgesia
Current Drug Abuse Reviewse, 2009Hyperalgesia has been observed during ethanol withdrawal, comparable to the hyperalgesia observed during withdrawal from opioids. To determine the extent of this phenomenon and its potential mechanisms, both behavioral and in vitro studies are examined, and the roles of GABA(A), glutamate and other receptors in mediating the acute and chronic ...
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Barbiturate hyperalgesia revisited
Regional Anesthesia and Pain Medicine, 2004Alfred P J, Lake, Stephan, Hugo
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