Results 311 to 320 of about 98,039 (356)
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Journal of Musculoskeletal Pain, 2002
SUMMARYObjectives: The aim of this paper is to give a brief introduction to the mechanisms and manifestations related to muscle hyperalgesia. It has become increasingly evident that muscle hyperalgesia plays an important role in chronic musculoskeletal pain.
Arendt-Nielsen, Lars +1 more
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SUMMARYObjectives: The aim of this paper is to give a brief introduction to the mechanisms and manifestations related to muscle hyperalgesia. It has become increasingly evident that muscle hyperalgesia plays an important role in chronic musculoskeletal pain.
Arendt-Nielsen, Lars +1 more
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Opioid-induced hyperalgesia: pathophysiology and clinical implications.
Journal of Opioid Management, 2018BACKGROUND Opioid-induced hyperalgesia (OIH) refers to a phenomenon whereby opioid administration results in a lowering of pain threshold, clinically manifest as apparent opioid tolerance, worsening pain despite accelerating opioid doses, and abnormal ...
S. Mitra
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Current Opinion in Supportive & Palliative Care, 2010
Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
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Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
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Synaptic mechanisms of hyperalgesia [PDF]
, 2000 Publisher Summary Hyperalgesia and allodynia often aggravate pain for variable periods after trauma, surgery, and inflammation. Pain that is induced by normally nonpainful stimuli (allodynia) or abnormally intense pain elicited by noxious stimuli (hyperalgesia) may be the consequence of an increased sensitivity of nociceptors (peripheral ...
C. Brechtel +4 more
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Journal of PeriAnesthesia Nursing, 2012
HYPERALGESIAMEANS INCREASED sensitivity to pain. Opioid-induced hyperalgesia (OIH) is a paradoxical situation in which increasing doses of opioid result in increasing sensitivity to pain. OIH has been identified as a clinical reality, but the incidence of clinically significant OIH is unknown.
Margo McCaffery, Chris Pasero
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HYPERALGESIAMEANS INCREASED sensitivity to pain. Opioid-induced hyperalgesia (OIH) is a paradoxical situation in which increasing doses of opioid result in increasing sensitivity to pain. OIH has been identified as a clinical reality, but the incidence of clinically significant OIH is unknown.
Margo McCaffery, Chris Pasero
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Spinal Mediators of Hyperalgesia
Drugs, 1994Neuronal plasticity associated with altered sensations arising from tissue damage involves both established (e.g. substance P and excitatory amino acids) and novel (e.g. nitric oxide and metabolites of arachidonic acid) mediators released from terminals of primary afferent neurons or synthesised in the spinal cord.
G. F. Gebhart, S. T. Meller
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Opioid Tolerance and Hyperalgesia
Medical Clinics of North America, 2007Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain.
Grace Chang, Jianren Mao, Lucy Chen
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Hyperalgesia and opioid switching
American Journal of Hospice and Palliative Medicine®, 2005Opioids, intended to abolish pain, can unexpectedly produce hyperalgesia, particularly during rapid opioid escalation. Opioid switching could be a therapeutic option in a condition of opioid-induced tolerance or hyperalgesia, but conversion ratios between opioids are difficult to apply in this context and require strict surveillance and expertise ...
Edoardo Arcuri, Sebastiano Mercadante
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Kinins and their receptors in hyperalgesia
Canadian Journal of Physiology and Pharmacology, 1997Kinins (bradykinin, kallidin) are produced at sites of injury and inflammation and serve a critical role in signaling tissue distress as well as organising tissue responsiveness to injury. The acute activation and prolonged sensitization of fine afferents, to produce pain and hyperalgesia, are important in the protective responses that occur to ...
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Nature Reviews Neuroscience, 2014
In mice with mechanical hyperalgesia, reactivation of the sensitized pain pathways renders the hyperalgesic state labile and susceptible to being reversed.
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In mice with mechanical hyperalgesia, reactivation of the sensitized pain pathways renders the hyperalgesic state labile and susceptible to being reversed.
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