Results 91 to 100 of about 5,947 (218)
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese +12 more
wiley +1 more source
RISK FACTORS OF RETINOPATHY OF PREMATURITY IN CHILDREN BORN FROM MULTIPLE PREGNANCIES
Purpose. To identify significant risk factors for the «threshold» retinopathy of prematurity (ROP) in children born from multiple pregnancies.Material and methods. The paper is based on a retrospective analysis of case histories of premature infants with
I. E. Panova +2 more
doaj +1 more source
ABSTRACT Background and Aims Herpes simplex virus (HSV) infection is common worldwide, but hepatic involvement is rare. HSV hepatitis is an uncommon yet frequently catastrophic cause of acute hepatitis and acute liver failure (ALF), accounting for < 1% of ALF cases while carrying very high mortality when diagnosis and antiviral therapy are delayed ...
Mario U. Mondelli +5 more
wiley +1 more source
Biochemical and molecular aspects of genetic disorders of bilirubin metabolism
Bilirubin, the oxidative product of heme in mammals, is excreted into the bile after its esterification with glucuronic acid to polar mono- and diconjugated derivatives.
Yoshikazu Emi +5 more
core +1 more source
Extranodal natural killer/T‐cell lymphoma: From fatal to curable
Abstract Extranodal natural killer (NK)/T‐cell lymphoma (ENKTCL) is one of the most aggressive non‐Hodgkin lymphomas characterized by NK‐cell or T‐cell origins, a geographic prevalence in Asian and South American populations, and Epstein–Barr virus (EBV) infection.
Jie Xiong +12 more
wiley +1 more source
Inherited Disorders of Bilirubin Metabolism [PDF]
Inherited disorders of bilirubin metabolism - hereditary hyperbilirubinemias - are metabolic disorders manifested in early childhood. Unconjugated hyperbilirubinemias result from the defect of the enzyme uridine diphosphoglucuronosyltransferase (UGT1A1).
Šlachtová, Lenka
core
Pathologic Features of Hereditary Cholestatic Diseases
The inherited diseases causing conjugated hyperbilirubinemia are diverse, with variability in clinical severity, histologic appearance, and time of onset.
Andrew D. Clouston, Clouston, Andrew D.
core +1 more source
Significance of UGT1A1*28 genotype in patients with advanced liver injury caused by chronic hepatitis C [PDF]
Background: Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not elucidated. Genetic variations in UGT1A1 gene are the most common cause
Jordović Jelena +13 more
doaj
Background Neonatal cholestasis is a multifactorial disorder that may result from metabolic, infectious, or genetic etiologies. Dehydrated hereditary stomatocytosis (DHS), a rare autosomal dominant hemolytic anemia caused by PIEZO1 gene mutations, is ...
Deepak Borde +3 more
doaj +1 more source
Infantile Pyknocytosis in a Premature Dichorionic Diamniotic Twin
Infantile pyknocytosis is a rare and self-limiting cause of hemolytic anemia in neonates. It can result in severe anemia and hyperbilirubinemia. The pathogenesis is unknown: a genetic origin has been discussed; however, based on the current literature it
van Wijk, Richard +3 more
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