Results 91 to 100 of about 5,947 (218)

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

open access: yesEuropean Journal of Haematology, Volume 117, Issue 1, Page 24-41, July 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese   +12 more
wiley   +1 more source

RISK FACTORS OF RETINOPATHY OF PREMATURITY IN CHILDREN BORN FROM MULTIPLE PREGNANCIES

open access: yesОфтальмохирургия, 2017
Purpose. To identify significant risk factors for the «threshold» retinopathy of prematurity (ROP) in children born from multiple pregnancies.Material and methods. The paper is based on a retrospective analysis of case histories of premature infants with
I. E. Panova   +2 more
doaj   +1 more source

Herpes Simplex Virus Hepatitis: An Overlooked Cause of Acute Liver Failure Across a Broad Spectrum of Immunocompromise

open access: yesLiver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background and Aims Herpes simplex virus (HSV) infection is common worldwide, but hepatic involvement is rare. HSV hepatitis is an uncommon yet frequently catastrophic cause of acute hepatitis and acute liver failure (ALF), accounting for < 1% of ALF cases while carrying very high mortality when diagnosis and antiviral therapy are delayed ...
Mario U. Mondelli   +5 more
wiley   +1 more source

Biochemical and molecular aspects of genetic disorders of bilirubin metabolism

open access: yes, 1998
Bilirubin, the oxidative product of heme in mammals, is excreted into the bile after its esterification with glucuronic acid to polar mono- and diconjugated derivatives.
Yoshikazu Emi   +5 more
core   +1 more source

Extranodal natural killer/T‐cell lymphoma: From fatal to curable

open access: yesCA: A Cancer Journal for Clinicians, Volume 76, Issue 4, July/August 2026.
Abstract Extranodal natural killer (NK)/T‐cell lymphoma (ENKTCL) is one of the most aggressive non‐Hodgkin lymphomas characterized by NK‐cell or T‐cell origins, a geographic prevalence in Asian and South American populations, and Epstein–Barr virus (EBV) infection.
Jie Xiong   +12 more
wiley   +1 more source

Inherited Disorders of Bilirubin Metabolism [PDF]

open access: yes, 2013
Inherited disorders of bilirubin metabolism - hereditary hyperbilirubinemias - are metabolic disorders manifested in early childhood. Unconjugated hyperbilirubinemias result from the defect of the enzyme uridine diphosphoglucuronosyltransferase (UGT1A1).
Šlachtová, Lenka
core  

Pathologic Features of Hereditary Cholestatic Diseases

open access: yes, 2018
The inherited diseases causing conjugated hyperbilirubinemia are diverse, with variability in clinical severity, histologic appearance, and time of onset.
Andrew D. Clouston, Clouston, Andrew D.
core   +1 more source

Significance of UGT1A1*28 genotype in patients with advanced liver injury caused by chronic hepatitis C [PDF]

open access: yesJournal of Medical Biochemistry, 2019
Background: Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not elucidated. Genetic variations in UGT1A1 gene are the most common cause
Jordović Jelena   +13 more
doaj  

Neonatal cholestatic cirrhosis in an infant with dehydrated hereditary stomatocytosis due to a PIEZO1 mutation: a rare association

open access: yesEgyptian Pediatric Association Gazette
Background Neonatal cholestasis is a multifactorial disorder that may result from metabolic, infectious, or genetic etiologies. Dehydrated hereditary stomatocytosis (DHS), a rare autosomal dominant hemolytic anemia caused by PIEZO1 gene mutations, is ...
Deepak Borde   +3 more
doaj   +1 more source

Infantile Pyknocytosis in a Premature Dichorionic Diamniotic Twin

open access: yes, 2021
Infantile pyknocytosis is a rare and self-limiting cause of hemolytic anemia in neonates. It can result in severe anemia and hyperbilirubinemia. The pathogenesis is unknown: a genetic origin has been discussed; however, based on the current literature it
van Wijk, Richard   +3 more
core  

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