Results 111 to 120 of about 51,743 (231)

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

The Management of Congenital Cytomegalovirus Infection in an Era of Universal Newborn CMV Screening

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The most common infectious disease responsible for paediatric developmental disability is congenital infection with human cytomegalovirus (cCMV). Many serious sequelae are caused by cCMV, including microcephaly, intracranial calcifications, neuronal migration defects, seizure disorders, developmental delay, and sensorineural hearing loss (SNHL)
Emily R. Harrison, W. Charles Huskins, Mark R. Schleiss   +2 more
wiley   +1 more source

Antioxidant vitamins and hyperbilirubinemia in neonates

GMS German Medical Science, 2007
Objective: Low antioxidant system may contribute to the severity of neonatal hyperbilirubinemia. The aim of this research was to explore the relationship between plasma vitamin E and C levels and the severity of hyperbilirubinemia in full-term neonates ...
Obediat, Ahmad D., Salim, Ahmad M., Nusier, Mohamad K., Abdul-Razzak, Khalid K.   +3 more
doaj  

Successful conservative management of a dog with postoperative bile peritonitis after cholecystectomy

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Summary An 11‐year‐old, female, spayed chihuahua was diagnosed with septic bile peritonitis secondary to gall bladder rupture. Surgical treatment consisted of cholecystectomy, placement of an abdominal drain and an oesophagostomy tube. The dog developed aspiration pneumonia alongside a recurrent bile peritonitis postoperatively.
Lydia Tan Yi Shean, Phil H. Franklin
wiley   +1 more source

A rare cause of hyperbilirubinemia in a newborn: bilateral adrenal hematoma

The Turkish Journal of Pediatrics, 2008
Hyperbilirubinemia is an important health problem in newborns. The most common causes are Rh and ABO incompatibility, hemolytic anemias, enzyme deficiencies, sepsis, hypothyroidism, pyloric stenosis and breast-milk jaundice.
Selahattin Katar, Hatice Oztürkmen-Akay, Celal Devecioğlu, Mustafa Taşkesen   +3 more
doaj  

Heart Rate Variability in Newborns From Diabetic Mothers: Clinical Application and Significance

Annals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
Risk factors for GDM contribute to a hyperglycemic intrauterine environment, which may in turn impair ANS function in the offspring. Altered ANS activity can be assessed through measures such as HRV. ABSTRACT Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, arising from inadequate insulin secretion and increased ...
Virginia Beretta, Laura Cannavò, Sebastiano Ravenda, Chiara Petrolini, Vincenzo Raitano, Sabrina Moretti, Valentina Dell'Orto, Serafina Perrone   +7 more
wiley   +1 more source

Hemophagocytic Macrophages in the Peripheral Blood of a Critically Ill Patient With COVID‐19 and RSV Infection

American Journal of Hematology, Volume 101, Issue 5, Page 1070-1071, May 2026.
Ashik Zala, Ahmed Sadek, Ahmed Elsaid, Ketan C. Patel, Maximiliano Ramia De Cap, Barbara J. Bain   +5 more
wiley   +1 more source

1 g/h magnesium sulfate maintenance for eclampsia prevention is enough

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 5, Page 771-777, May 2026.
Magnesium sulfate maintenance regimen of 1 g/h seems as effective as the 2 g/h regimen for the prevention of eclampsia, with decreased incidence of maternal side effects. Abstract We conducted two systematic reviews including only randomized controlled trials (RCTs) comparing magnesium sulfate vs placebo/no treatment, as well as 2 g/h vs 1 g/h ...
Alessandro Petrecca, Benedetta Bina, Tullio Ghi, Vincenzo Berghella   +3 more
wiley   +1 more source

Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population

BMC Pediatrics
Background Severe neonatal hyperbilirubinemia could lead to kernicterus and neonatal death. This study aimed to analyze the association between single nucleotide polymorphisms in genes involved in bilirubin metabolism and the incidence of severe ...
Juan Fan, Hua-Yun He, Huan-Huan Li, Pi-Liu Wu, Lei Tang, Bo-Yin Deng, Wen-Hui Dong, Jian-Hui Wang   +7 more
doaj   +1 more source