Results 41 to 50 of about 230,082 (281)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The numerical solution of the nonlinear hyperbolic-parabolic heat equation

Discrete and Continuous Models and Applied Computational Science
The article discusses a mathematical model and a finite-difference scheme for the heating process of an infinite plate. The disadvantages of using the classical parabolic heat equation for this case and the rationale for using the hyperbolic heat ...
Vladislav N. Khankhasaev, Safron A. Bairov   +1 more
doaj   +1 more source

Singular solitons in the pseudo-parabolic model arising in nonlinear surface waves

Results in Physics, 2019
This manuscript aims to construct a family of travelling wave solutions to the high nonlinearity differential equation for obtaining new hyperbolic function solutions by using an analytical method, which is based on the exponential function.
Onur Alp Ilhan, Alaattin Esen, Hasan Bulut, Haci Mehmet Baskonus   +3 more
doaj   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

A Note on the Second Order of Accuracy Stable Difference Schemes for the Nonlocal Boundary Value Hyperbolic Problem

Abstract and Applied Analysis, 2012
The second order of accuracy absolutely stable difference schemes are presented for the nonlocal boundary value hyperbolic problem for the differential equations in a Hilbert space H with the self-adjoint positive definite operator A.
Allaberen Ashyralyev, Ozgur Yildirim
doaj   +1 more source

Fourier and Gegenbauer expansions for a fundamental solution of the Laplacian in the hyperboloid model of hyperbolic geometry

, 2012
Due to the isotropy $d$-dimensional hyperbolic space, there exist a spherically symmetric fundamental solution for its corresponding Laplace-Beltrami operator.
Abramowitz M, Andrews G E, Beltrami E, Bers L, Byrd P F, Cohl H S, Cohl H S, Cohl H S, E G Kalnins, Erdélyi A, Erdélyi A, Fano U, Folland G B, Fox L, Gilbarg D, Gradshteyn I S, Grigor’yan A A, Grigor’yan A A, Grigor’yan A A, H S Cohl, Helgason S, Izmest’ev A A, Kalnins E G, Lee J M, Livio M, Losev A G, Magnus W, Morse P M, Olevskii˘ M N, Olver F W J, Olver F W J, Schoen R, Thurston W P, Trudeau R J, Vilenkin N Ja   +34 more
core   +2 more sources

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

A new spline in compression method of order four in space and two in time based on half-step grid points for the solution of the system of 1D quasi-linear hyperbolic partial differential equations

Advances in Difference Equations, 2017
In this paper, we propose a new three-level implicit method based on a half-step spline in compression method of order two in time and order four in space for the solution of one-space dimensional quasi-linear hyperbolic partial differential equation of ...
RK Mohanty, Gunjan Khurana
doaj   +1 more source

Local and Global Stability of Certain Mixed Monotone Fractional Second Order Difference Equation with Quadratic Terms

Axioms, 2021
This paper investigates the local and global character of the unique positive equilibrium of a mixed monotone fractional second-order difference equation with quadratic terms.
Mirela Garić-Demirović, Sabina Hrustić, Zehra Nurkanović   +2 more
doaj   +1 more source