Results 41 to 50 of about 67,397 (310)

Hypercalcemia of Malignancy in Thymic Carcinoma: Evolving Mechanisms of Hypercalcemia and Targeted Therapies

Case Reports in Endocrinology, 2017
Here we describe, to our knowledge, the first case where an evolution of mechanisms responsible for hypercalcemia occurred in undifferentiated thymic carcinoma and discuss specific management strategies for hypercalcemia of malignancy (HCM).
Cheng Cheng, Jose Kuzhively, Sanford Baim   +2 more
doaj   +1 more source

A Case of Severe Hypercalcemia Causing Acute Kidney Injury: An Unusual Presentation of Acute Lymphoblastic Leukemia [PDF]

Childhood Kidney Diseases, 2017
Severe hypercalcemia is rarely encountered in children, even though serum calcium concentrations above 15-16 mg/dL could be life-threatening. We present a patient having severe hypercalcemia and azotemia.
Hye Sun Hyun, Peong Gang Park, Jae Choon Kim, Kyun Taek Hong, Hyoung Jin Kang, Kyung Duk Park, Hee Young Shin, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong   +9 more
doaj   +1 more source

Causes of hypercalcemia in renal transplant recipients: persistent hyperparathyroidism and others [PDF]

Brazilian Journal of Medical and Biological Research
Hypercalcemia is common in patients after kidney transplantation (KTx) and is associated with persistent hyperparathyroidism in the majority of cases. This retrospective, single-center study evaluated the prevalence of hypercalcemia after KTx.
M. Moyses-Neto, T.M.P. Garcia, M.E.P. Nardin, V.A. Muglia, C.A.F. Molina, E.A. Romao   +5 more
doaj   +2 more sources

GP56 Severe hypercalcemic crisis in an infant with idiopathic infantile hypercalcemia caused by mutation in CYP24A1 gene

Abstracts, 2019
Introduction The presence of CYP24A1 mutations explains the increased sensitivity to vitamin D in patients with idiopathic infantile hypercalcemia and is a genetic risk factor for the development of symptomatic hypercalcemia that may be triggered by ...
Orsolya Racz, Francesco Emma, M. Konrad, O. Fufezan, Bogdan Bulată, Adriana Bungardi, S. Căinap   +6 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

PTHrP-Producing Renal Cell Carcinoma Presenting as Rapidly Progressive Cognitive Impairment: A Case Report. [PDF]

IJU Case Rep
ABSTRACT Introduction Humoral hypercalcemia of malignancy (HCM) caused by parathyroid hormone–related peptide (PTHrP) is a common paraneoplastic syndrome, and renal cell carcinoma (RCC) is one of the main causes. However, initial presentation with rapidly progressive cognitive decline is rare.
Yano F, Sawada N, Tanaka N, Hikawa K, Hirose K, Ohtake Y, Mitsui T.   +6 more
europepmc   +2 more sources

Challenges in the management of hypercalcemia in pregnancy – Case report of two cases

Case Reports in Women's Health
Hypercalcemia in pregnancy is rare and can pose a great diagnostic challenge due to its asymptomatic presentation. It is associated with maternal complications such as urolithiasis, pancreatitis, renal insufficiency and preeclampsia, fetal complications ...
Shu Hui Lim, Weiying Lim, Serene Pei Ting Thain   +2 more
doaj   +1 more source

Severe hypercalcemia caused by parathyroid hormone in a rectal cancer metastasis: a case report

BMC Endocrine Disorders, 2021
Background Hypercalcemia of malignancy is relatively common in several cancers. However, in colorectal cancer, paraneoplastic phenomena that cause hypercalcemia is uncommon.
Vegard Heimly Brun, Erik Knutsen, Helge Stenvold, Hanne Halvorsen   +3 more
doaj   +1 more source

Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases

Journal of Applied Genetics, 2017
Idiopathic infantile hypercalcemia (IIH) is a mineral metabolism disorder characterized by severe hypercalcemia, failure to thrive, vomiting, dehydration, and nephrocalcinosis.
E. Pronicka, E. Ciara, P. Halat, A. Janiec, Marek Wójcik, E. Rowińska, D. Rokicki, P. Płudowski, E. Wojciechowska, A. Wierzbicka, J. Książyk, A. Jacoszek, M. Konrad, K. Schlingmann, M. Litwin   +14 more
semanticscholar   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source