Results 41 to 50 of about 23,156 (149)

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Status epilepticus secondary to milk-alkali syndrome induced by hypercalcemia (oral antacids) [PDF]

, 2011
Milk-alkali syndrome is mainly caused by the ingestion of large amounts of calcium and absorbable alkali. This syndrome can lead to metastatic calcification, renal failure and metabolic alkalosis secondary to hypercalcemia.
Al Samara, Mershed, Kashouty, Rabih, Yono, Noor   +2 more
core   +1 more source

Outcomes of daratumumab–bortezomib–thalidomide–dexamethasone in treatment‐naive systemic AL amyloidosis

British Journal of Haematology, Volume 206, Issue 4, Page 1141-1148, April 2025.
Summary Systemic light chain (AL) amyloidosis is an incurable disorder caused by extra‐cellular deposition of light‐chain aggregates in critical organs. An immunomodulatory agent‐based quadruplet including anti‐CD38 therapy has not been investigated as a first‐line treatment in AL amyloidosis.
Jahanzaib Khwaja, Sriram Ravichandran, Oliver Cohen, Darren Foard, May Low, Ana Martinez‐Naharro, Lucia Venneri, Marianna Fontana, Philip N. Hawkins, Julian Gillmore, Helen J. Lachmann, Carol Whelan, Shameem Mahmood, Ashutosh Wechalekar   +13 more
wiley   +1 more source

Acute pancreatitis after liver transplantation: incidence and contributing factors [PDF]

, 1995
In order to assess the incidence and possible predisposing and contributing factors in the development of acute pancreatitis after liver transplantation, we reviewed the medical records of all 1832 adult patients who underwent 2161 orthotopic liver ...
Fung, JJ, Karavias, D, Krokos, NV, Ramos, E, Starzl, TE, Tepetes, K, Todo, S, Tzakis, A   +7 more
core   +1 more source

Approach to Hypercalcemia

McGill Journal of Medicine, 2022
Hypercalcemia is a presentation commonly encountered in the clinical setting. Due to its vast differential diagnosis, a systematic approach is necessary when approaching patients with hypercalcemia. This article presents a simple, yet thorough approach to help clinicians determine the etiology of their patients' hypercalcemia.
openaire   +3 more sources

Distinct characteristics and social determinants in adult T‐cell leukaemia/lymphoma patients at a tertiary cancer centre in Canada

British Journal of Haematology, EarlyView.
Adult T‐cell leukaemia/lymphoma (ATLL) is a rare, aggressive cancer linked to HTLV‐1, with poor outcomes. We analysed 79 ATLL patients (1993–2023) at our institution. The median age at diagnosis was 47 years, with 72% of patients of Caribbean origin. Median progression‐free and overall survival were 10.2 and 16.2 months respectively. CNS involvement at
Tomohiro Aoki, Mary Salib, Adam Suleman, Noorhan Ghanem, Michael Hong, Agustina Boriano, Abi Vijenthira, Anca Prica, John Kuruvilla, Vishal Kukreti, Michael Crump, Robert Kridel   +11 more
wiley   +1 more source

A rare case of appendicular skeleton localization in a patient with chronic lymphocytic leukemia successfully treated with salvage radiation therapy [PDF]

, 2017
Bone involvements in chronic lymphocytic leukemia (CLL) are considered rare events, and the English-language medical literature describes them only in sporadic case reports. Consequently, robust indications for a rational clinical management are lacking.
Al Sayyad, Said, Arico, Demetrio, Di Cristofano, Claudio, Marchione, Anna Maria, Petrozza, Vincenzo, Porta, Natale, Ronco, Francesca, Russi, Elvio Grazioso, Sceni, Giuseppe, Stelitano, Caterina, Tuscano, Carmelo, Versace, Paolo, Vincelli, Iolanda Donatella   +12 more
core   +1 more source

Screening for monoclonal gammopathy of undetermined significance is contraindicated

British Journal of Haematology, EarlyView.
Incidence of multiple myeloma is about 1.8/100 000. About 3%–5% of adults >50 years of age are diagnosed with monoclonal gammopathy of undetermined significance (MGUS). The prevalence is higher if diagnosis is based on an abnormal ratio of serum free light chains.
Gurmukh Singh
wiley   +1 more source

Primary hyperparathyroidism can generate recurrent pancreatitis and secondary diabetes mellitus – A case report [PDF]

, 2019
Introduction. Acute or recurrent pancreatitis may be a complication of primary hyperparathyroidism and patients with previous episodes of pancreatitis may develop secondary diabetes mellitus. Case report.
Dănciulescu Miulescu, Rucsandra Elena, Guja, Loreta, Mîndrescu, Nicoleta, Văcaru, Georgeta, Ștefănescu, Emil   +4 more
core   +1 more source

Safety and efficacy of calcipotriene plus betamethasone dipropionate topical suspension in the treatment of extensive scalp psoriasis in adolescents ages 12 to 17 years. [PDF]

, 2014
The objective of this study was to assess the safety and efficacy of the fixed combination calcipotriene 0.005% plus betamethasone dipropionate 0.064% topical suspension in adolescents with extensive scalp psoriasis.
Eichenfield, Lawrence F, Ganslandt, Cecilia, Kurvits, Merle, Schlessinger, Joel   +3 more
core   +1 more source