Results 51 to 60 of about 23,156 (149)

Immunosuppressive Effects of Multiple Myeloma‐Derived Extracellular Vesicles Through T Cell Exhaustion

Cancer Science, EarlyView.
Extracellular vesicles (EVs) derived from myeloma cells could potentially induce T cell exhaustion via the increase of the frequency of immune checkpoint marker‐positive CD8+ T cells and might thereby suppress T cell function. In addition, this immune escape mechanism from cytotoxic T cells is supported by the findings on SPHK1/S1P signaling from SPHK1‐
Shinya Hagiwara, Masaki Ri, Toru Ebina, Yoshiaki Marumo, Tomoyuki Nakamura, Kentaro Hirade, Takahiro Nakashima, Arisa Asano, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Ayako Masaki, Hirokazu Komatsu, Shinsuke Iida   +13 more
wiley   +1 more source

Use of Data Mining in the Establishment of Reference Intervals for Albumin‐Adjusted Calcium

Clinical Endocrinology, EarlyView.
ABSTRACT Background Calcium homeostasis is critical for numerous physiological functions, and while total calcium is commonly measured in clinical practice, albumin‐adjusted calcium is widely used to account for protein binding, despite concerns about its accuracy and lack of standardized reference intervals.
Esra Paydaş Hataysal, Ferruh Kemal İşman   +1 more
wiley   +1 more source

Improved hypercalcemia after debulking of uremic tumoral calcinosis in a parathyroidectomized patient. [PDF]

, 2005
Uremic Tumoral Calcinosis (UTC) is a rare complication of chronic kidney disease on dialysis, characterized by large periarticular calcification. Among some cases, hypercalcemia with no conventional etiologies has been reported.
Bornemann, Michael, Fujiyoshi, Akira, Ng, Roland   +2 more
core  

Glycopyrronium 320 μg/mL in children and adolescents with severe sialorrhoea and neurodisabilities: An open‐label study extension of the SALIVA trial

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16268 Abstract Aims To test the long‐term efficacy, safety, and impact on quality of life (QoL) of an oral paediatric formulation of 320 μg/mL glycopyrronium in the 36‐week SALIVA (Sialanar plus orAl rehabiLitation against placebo plus oral rehabilitation for chIldren and ...
Pierre Fayoux, Mickael Dinomais, Helen Shaw, Frédéric Villain, Déborah Schwartz, Vincent Gautheron, Guy Letellier, Stéphane Auvin   +7 more
wiley   +1 more source

Cerebral palsy and perinatal mortality in children born in Norway to immigrant mothers

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16271 Abstract Aim To compare the prevalence and clinical characteristics of cerebral palsy (CP), and perinatal mortality, in children born to non‐immigrant mothers with children born to immigrant mothers. Method This was a registry‐based cross‐sectional study.
Maria Wiedswang Sigholt, Guro L. Andersen, Stian Lydersen, Liv Cecilie Vestrheim Thomsen, Torstein Vik, Sandra Julsen Hollung   +5 more
wiley   +1 more source

Chronic adult T-cell Leukemia in a young male after blood transfusion as a newborn [PDF]

, 2016
Human T-cell Lymphotropic virus type 1 (HTLV-1) is the etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HTM/TSP).
Altube, Alejandra, Berini, Carolina Andrea, Biglione, Mirna Marcela, Cabral Lorenzo, María Cecilia, Colucci, Magalí, Cánepa, Camila, Deves, Alberto, Halperin, Nora Silvia, Hermine, Olivier, Rojas, Francisca, Ruggieri, Matias   +10 more
core   +2 more sources

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

Developmental Medicine &Child Neurology, EarlyView.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B.
Russell C. Dale, Shekeeb Mohammad, Velda X. Han, Hiroya Nishida, Himanshu Goel, Stuart G. Tangye, Georgina Hollway, Esther Tantsis, Deepak Gill, Shrujna Patel, Chromatin Immune‐Brain Group, Michael Lonergan, Melanie Wong, Kavitha Kothur, Erica Tsang   +14 more
wiley   +1 more source

Primary Hyperparathyroidism in an Auto‐Transplanted Parathyroid Gland Within the Sternocleidomastoid Muscle

ANZ Journal of Surgery, EarlyView.
William MacFaul, Toby Hulf, Shad Khan
wiley   +1 more source

Deep developmental phenotyping in children with tuberous sclerosis complex, with and without autism

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16312 Abstract Aim To characterize autism and co‐occurring tuberous sclerosis‐associated neuropsychiatric disorders (TAND) in children with tuberous sclerosis complex (TSC), addressing evidence gaps by using deep developmental phenotyping in a single cohort.
Rebecca A. Mitchell, Francesca Lami, Sarah M. Barton, A. Simon Harvey, Katrina Williams   +4 more
wiley   +1 more source

Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin

The FEBS Journal, EarlyView.
The secretion of parathyroid hormone (PTH) from the chief cells in the parathyroid glands is regulated by the concentration of extracellular calcium. Epiprofin (Epfn) expression is induced by NFATc2 in response to elevated serum calcium, and Epfn negatively regulates PTH production.
Takashi Nakamura, Hannah M. Nakamura, Yasumasa Iwasaki, Motomi Enomoto‐Iwamoto, Noriaki Nakashima, Satoshi Fukumoto, Maurizio Pacifici, Masahiro Iwamoto, Minoru Wakamori   +8 more
wiley   +1 more source