Results 91 to 100 of about 128,840 (306)

Cardiometabolic Health and Risk of Breast Cancer Subtypes Among US Black Women

International Journal of Cancer, EarlyView.
ABSTRACT In the United States (US), cardiometabolic conditions and aggressive breast cancers are both more common among Black women than White women. Using data from 57,453 participants in the Black Women's Health Study (BWHS), we prospectively evaluated associations of body mass index (BMI), Type 2 diabetes, hypertension, and hypercholesterolemia with
Yifei Shan, Sarah M. Rothbard, Lynn Rosenberg, Julie R. Palmer, Mollie E. Barnard   +4 more
wiley   +1 more source

Causal relationship between mental disorders and hypercholesterolemia： a Mendelian randomization analysis

Sichuan jingshen weisheng
BackgroundMetabolic syndrome （MetS） is highly prevalent in patients with mental disorders， including elevated diastolic or systolic blood pressure， elevated fasting glucose， hypercholesterolemia， abdominal obesity and so on.
Zou Qian, Tang Ni, Liu Huanhui, Zhang Hanjing, Ma Xiaojie   +4 more
doaj   +1 more source

Increased body mass and depressive symptomatology are associated with hypercholesterolemia, among elderly individuals; results from the MEDIS study

Lipids in Health and Disease, 2009
Background Hypercholesterolemia is one of the most important factors causing cardiovascular disease (CVD). The aim of the present work was to evaluate the relationships between socio-demographic, clinical, lifestyle and depression status and the presence
Makri Kornilia, Metallinos George, Papairakleous Natassa, Katsarou Alexia, Micheli Mary, Bountziouka Vassiliki, Zeimbekis Akis, Lionis Christos, Tyrovolas Stefanos, Polychronopoulos Evangelos, Panagiotakos Demosthenes B   +10 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

The genetics of familial hypercholesterolemia and emerging therapies

, 2015
Anja Vogt Medizinische Klinik und Poliklinik IV, Klinikum der Unversität München, Munich, Germany Abstract: Familial hypercholesterolemia (FH) results in very high levels of atherogenic low-density lipoprotein (LDL) cholesterol from the time ...
Vogt A
core  

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Improving medication adherence in hypercholesterolemia: challenges and solutions

, 2014
Justin Gatwood,1 James E Bailey2 1University of Tennessee Health Science Center, College of Pharmacy, 2University of Tennessee Health Science Center, Center for Health System Improvement, Memphis, TN, USA Abstract: Medication nonadherence is a prevalent
Gatwood J, Bailey JE
core  

Familial hypercholesterolemia: experience from France

, 2018
International audiencePurpose of review We provide an overview of molecular diagnosis for familial hypercholesterolemia in France including descriptions of the mutational spectrum, polygenic susceptibility and perspectives for improvement in familial ...
Jean-Pierre Rabès, Alain Carrié, Sophie Béliard, Rabes, Jean-Pierre, Beliard, Sophie, Carrie, Alain   +5 more
core   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory‐Based Analysis

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Cerebral microbleeds (CMBs) are a key imaging marker of cerebral amyloid angiopathy (CAA), but their individual spatial distribution and potential clustering remain poorly understood. Purpose This study assessed whether CMBs exhibit patient‐specific, flow territory‐based clustering in sporadic (sCAA) and Dutch‐type hereditary CAA (D‐
Manon R. Schipper, Reinier G. J. van der Zwet, Jelle J. Goeman, Thijs W. van Harten, Emma A. Koemans, Marieke J. H. Wermer, Marianne A. A. van Walderveen, Matthias J. P. van Osch   +7 more
wiley   +1 more source