Results 171 to 180 of about 128,840 (306)

Validated Polygenic Risk Scores Complement Monogenic Testing in South Asian Patients With Familial Hypercholesterolemia. [PDF]

JACC Asia
Abraham N, Menon R, Pavithran PV, Udhwani L, Bassi A, Samson PL, Anjanappa R, Gupta R, Vedam L R, Menon U, Bhavani N, Nair V, Kumar H, Nair DR.   +13 more
europepmc   +1 more source

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Journal of Internal Medicine, EarlyView.
Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo   +3 more
wiley   +1 more source

The Spectrum of Genetic Causes of Familial Hypercholesterolemia Phenotype. [PDF]

Curr Atheroscler Rep
Bourbon M, Alves AC, Chora JR, Hooper AJ, Abifadel M.   +4 more
europepmc   +1 more source

A Framework for Ethical and Clinical Governance Evaluation of Innovative Medicines in Children: A Mixed Methods Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this project was to develop and implement a working definition and ethical framework for use of innovative medicine in contemporary Australian paediatric practice. Methods A mixed methods research methodology was undertaken using a Delphi process to establish a definition of innovative medicines in paediatric patients.
Sonya Stacey, Jamie Lam, Fiona Gregory, Shakira Wild, Steven McTaggart, Helen Irving   +5 more
wiley   +1 more source

Atorvastatin Mitigates Hypercholesterolemia-Induced Alterations in Cerebral Mitochondrial Dehydrogenases in Rats. [PDF]

Int J Mol Sci
Belczyk M, Gawedzka A, Drag J, Stelmach O, Knapik-Czajka M.   +4 more
europepmc   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Enlicitide, a Novel Oral Macrocyclic Peptide PCSK9 Inhibitor for Lipid Lowering: A Systematic Review and Meta-Analysis. [PDF]

J Cardiovasc Dev Dis
Yagmur B, Cekirdekci EI.
europepmc   +1 more source

Familial hypercholesterolemia

Clinica Chimica Acta, 1971
Kehayoglou, K.A., Karli, N.J., Kiriazidis, K.J., Theodossiou, A.   +3 more
openaire   +3 more sources

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source

Mouse Models of Atherosclerosis: What They Teach Us, What They Miss, and When to Use Them. [PDF]

Bioengineering (Basel)
Geng X, McKee AR, Rosa-Garrido M, Cobo I.   +3 more
europepmc   +1 more source