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Concurrent hypercortisolism and hypermineralocorticoidism
The American Journal of Medicine, 1977Hypertension and hypokalemia occur in patients with Cushing's syndrome whereas aldosterone production is normal and plasma renin activity is usually normal or increased. A normal aldosterone level in the face of suppressed plasma renin activity is unusual and suggests excess mineralocorticoid hormone activity.
M J, Hogan, M, Schambelan, E G, Biglieri
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Medical therapy in severe hypercortisolism
Best Practice & Research Clinical Endocrinology & Metabolism, 2021Severe hypercortisolism is characterized as a life-threatening endocrine condition in patients with Cushing syndrome, usually related to the concomitant onset of one or more comorbidities, requiring rapid normalization of cortisol concentrations and aggressive treatment of associated complications.
Júlia Vieira Oberger Marques +1 more
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Cushing's Disease Without Hypercortisolism
The Journal of Clinical Endocrinology & Metabolism, 1970ABSTRACT A patient with Addison's disease remained hyperpigmented despite customary replacement therapy with glucocorticoid and mineralocorticoid. Plasma ACTH and MSH concentrations were found to be elevated, but could be suppressed by large doses of glucocorticoid, indicating a pituitary origin for these hormones.
R N, Dexter +4 more
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Pharmacological treatment of hypercortisolism
Current Opinion in Endocrinology, Diabetes & Obesity, 2008To consider the current status and types of drug therapy aimed at restoring eucortisolaemia in patients with Cushing's syndrome.Advances such as laparoscopic adrenalectomy modify the exact placing of drug therapy among the wide variety of therapies available to treat patients with Cushing's syndrome because of different causes; nonetheless, it is now ...
Stephen, Shalet, Annice, Mukherjee
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Urologic Clinics of North America
Primary hypercortisolism, commonly known as Cushing's syndrome, is an endocrine disorder characterized by excessive cortisol production by the adrenal glands, independent of adrenocorticotropic hormone stimulation. This disorder presents with a wide range of clinical manifestations, including metabolic, cardiovascular, and psychological disturbances ...
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Primary hypercortisolism, commonly known as Cushing's syndrome, is an endocrine disorder characterized by excessive cortisol production by the adrenal glands, independent of adrenocorticotropic hormone stimulation. This disorder presents with a wide range of clinical manifestations, including metabolic, cardiovascular, and psychological disturbances ...
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Update on Hypercortisolism Therapy
2016Treating Cushing's syndrome is very challenging and should be tailored to the patient. Surgery is considered the gold standard treatment for both pituitary adrenocorticotropic hormone (ACTH)-secreting adenomas, ectopic ACTH-secreting tumors and adrenal tumors, as the chance to be successful is high, especially for adrenal tumors, when performed in ...
Giorgio, Arnaldi, Laura, Trementino
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Subclinical hypercortisolism in adrenal incidentaloma
Current Opinion in Endocrinology, Diabetes & Obesity, 2015The article aims to update the reader on current developments in the area of adrenal incidentaloma complicated by subclinical hypercortisolism. We will discuss different diagnostic strategies and complications associated with this disease, and address the conflicting opinions related to the treatment of these patients.Depending on diagnostic criteria ...
Miguel, Debono, John, Newell-Price
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Pathophysiology of hypercortisolism in depression
Acta Psychiatrica Scandinavica, 2007Objective: The mechanisms mediating hypercortisolemia in depression remain controversial. Adopting the biomarker strategy, we studied adrenocorticotropin (ACTH) and cortisol dynamics in hypercortisolemic and non‐hypercortisolemic depressed in‐patients, and in normal volunteers.Method: Deconvolution analysis of 24‐h pulsatile secretion, approximate ...
B J, Carroll +7 more
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Skeletal Fragility in Endogenous Hypercortisolism
2016Skeletal fragility is a frequent complication of endogenous hypercortisolism, and fragility fractures may be the first clinical manifestation of the disease. Fractures involve more frequently the vertebrae and may occur in 30-50% of the patients exposed to glucocorticoid excess, in close relationship with severity and duration of hypercortisolism ...
MAZZIOTTI G +4 more
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Recent Advances on Subclinical Hypercortisolism
Endocrinology and Metabolism Clinics of North America, 2018During the last 20 years, a significant body of literature has accumulated regarding subclinical hypercortisolism in patients with adrenal incidentalomas. Retrospective studies have indicated these patients have an increase in cardiovascular events and mortality.
ZAVATTA, GUIDO, Di Dalmazi, Guido
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