Results 41 to 50 of about 10,507 (195)

Hypereosinophilic Syndrome: Contemporary Approaches to Molecular-Genetic Diagnostics and Gene-Engineered Biologic Therapy

Медицина и биотехнологии
Introduction. In recent years, there has been a growing interest among researchers in conditions associated with hypereosinophilia and the therapeutic potential of genetically engineered biological agents.
Larisa A. Balykova, Anna V. Krasnopolskaya, Marina V. Shirmankina, Diva Augusta T. Mendes, Anastasia M. Khanina   +4 more
doaj   +1 more source

Right sided heart failure secondary to hypereosinophilic cardiomyopathy – clinical manifestation and diagnostic pathway

Radiology Case Reports, 2020
Hypereosinophilic cardiomyopathy is a rare restrictive cardiomyopathy which often presents with left-sided heart failure. We present an interesting case of a 58-year-old male patient with known hypereosinophillic syndrome who had presented with ...
Jennie Han, BA, BM BCh, Mohammad Ramtoola, MB ChB, Muhammad Shahzad, MBBS, Kenneth Okonkwo, MBBS, Nadeem Attar, MBBS   +4 more
doaj   +1 more source

Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions [PDF]

, 2018
Eosinophilic gastrointestinal disorders are a set of conditions with a wide range of clinical manifestations and treatment modalities. The disorders are suspected to result from an abnormal inflammatory response to allergen(s), and individuals may ...
Gupta, Sandeep K., Naramore, Sara
core   +1 more source

Tezepelumab for refractory eosinophilic granulomatosis with polyangiitis-related asthma

Respiratory Research
Conventional immunosuppressants are ineffective for the management of EGPA-related asthma. Tezepelumab is a human monoclonal antibody that inhibits thymic stromal lymphopoietin (TLSP) that has proven efficacy in several phase 3 studies for the treatment ...
Nina Vincent-Galtié, Quentin Marquant, Emilie Catherinot, Felix Ackermann, Antoine Magnan, Colas Tcherakian, Matthieu Groh   +6 more
doaj   +1 more source

Idiopathic hypereosinophilic syndrome with pulmonary hypertension

Pulmonary Circulation, 2018
Hypereosinophilic syndrome is a myeloproliferative disorder characterized by persistent eosinophilia with involvement of multiple organs. The occurrence of severe pulmonary hypertension (PH) in the setting of hypereosinophilic syndrome is very uncommon ...
Liping Zhang, Xia Peng, Binay Kumar Adhikari, Bo Li, Quan Liu, Jondo Mikeladze, Weihua Zhang   +6 more
doaj   +1 more source

Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006-2016). [PDF]

, 2019
BackgroundEosinophilic lung disease is a poorly understood inflammatory airway disease that results in substantial morbidity.ObjectiveTo describe clinical findings in dogs with eosinophilic lung disease defined on the basis of radiographic, bronchoscopic,
Dear, Jonathan D, Hulsebosch, Sean E, Johnson, Eric G, Johnson, Lynelle R, Vernau, William   +4 more
core   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Idiopathic Hypereosinophilic Syndrome with Multiple Organ Involvement

Case Reports in Oncology, 2021
Idiopathic hypereosinophilic syndrome is a rare disease which is diagnosed after excluding other conditions. The syndrome is characterized by multiple organ involvement including the heart, nervous system, lungs, and gastrointestinal tract.
Reham Abo Shdid, Bahjat Azrieh, Seham Alebbi, Shafik Mansour, Muhammad Naeem   +4 more
doaj   +1 more source

Adult human case of toxocariasis with pulmonary migratory infiltrate and eosinophilia [PDF]

, 2011
Introduction. Toxocariasis is a zoonosis which is in Serbia characterized with a very high infection rate of dogs and excessive contamination of the soil with the eggs of Toxocara canis, the agent of the disease.
Lalošević Dušan, Lalošević Vesna, Považan Anika, Považan Đorđe, Sečen Svetozar, Uzurov-Dinić Vera, Đurić Mirna   +6 more
core   +1 more source

Long‐Term Efficacy and Safety of Ligelizumab as Re‐Treatment in Patients With Chronic Spontaneous Urticaria

Allergy, EarlyView.
Ligelizumab re‐treatment in CSU patients showed sustained efficacy and tolerability. Over 50% achieved symptom control (UAS7 ≤ 6) by Week 12; benefits maintained through Week 52. No new safety signals observed; aligns with prior PEARL trial outcomes. CSU, chronic spontaneous urticaria; mg, milligram; q4w, every 4 weeks; UAS, urticaria activity score ...
Ana M. Gimenez‐Arnau, Marcus Maurer, Adam Reich, Chia‐Yu Chu, Diana Deleanu, Gordon Sussman, Jorge Sanchez, Knut Brockow, Koremasa Hayama, Michihiro Hide, Mohamed Denguezli, Raisa Meshkova, Roberta F. J. Criado, Sarbjit Saini, Solange Valle, Eva Hua, Pengpeng Wang, Alis Burciu, Isabelle Indermuehle, Vineeth Varanasi, Yolandi Joubert, Thomas Severin, Manmath Patekar   +22 more
wiley   +1 more source