Results 101 to 110 of about 97,549 (210)

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

open access: yesThe FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman   +13 more
wiley   +1 more source

Do temporary changes in earnings caused by mean reversion affect firms’ refinancing decisions?

open access: yesJournal of Financial Research, EarlyView.
Abstract We develop a dynamic two‐stage trade‐off model with refinancing when earnings are mean reverting. Our model predicts a negative relation between profitability and leverage at refinancing due to conservative debt increases. With multiple rounds of refinancing, the leverage–profitability relation may turn positive when firms have substantial ...
Elettra Agliardi   +3 more
wiley   +1 more source

Neurogenomic landscape associated with status‐dependent cooperative behaviour

open access: yesMolecular Ecology, EarlyView.
Abstract The neurogenomic mechanisms mediating male–male reproductive cooperative behaviours remain unknown. We leveraged extensive transcriptomic and behavioural data on a neotropical bird species (Pipra filicauda) that performs cooperative courtship displays to understand these mechanisms.
Peri E. Bolton   +6 more
wiley   +1 more source

The road less taken: Dihydroflavonol 4‐reductase inactivation and delphinidin anthocyanin loss underpins a natural intraspecific flower colour variation

open access: yesMolecular Ecology, EarlyView.
Abstract Visual cues are of critical importance for the attraction of animal pollinators, however, little is known about the molecular mechanisms underpinning intraspecific floral colour variation. Here, we combined comparative spectral analysis, targeted metabolite profiling, multi‐tissue transcriptomics, differential gene expression, sequence ...
Darren C. J. Wong   +6 more
wiley   +1 more source

Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque

open access: yesMolecular Ecology, EarlyView.
ABSTRACT Genetic variation that impacts gene regulation, rather than protein function, can have strong effects on trait variation both within and between species. Epigenetic mechanisms, such as DNA methylation, are often an important intermediate link between genotype and phenotype, yet genetic effects on DNA methylation remain understudied in natural ...
Christina E. Costa   +12 more
wiley   +1 more source

Diet Driven Differences in Host Tolerance Are Linked to Shifts in Global Gene Expression in a Common Avian Host‐Pathogen System

open access: yesMolecular Ecology, EarlyView.
ABSTRACT Wildlife have become increasingly dependent on anthropogenic resources, altering interactions between individuals and subsequently disease transmission. Further, nutritional quantity and quality impact an individual's ability to mitigate damage caused by infectious disease.
Erin L. Sauer   +5 more
wiley   +1 more source

Assessing lexical proficiency in Russian as a second language using indices of lexical sophistication, diversity, and fluency

open access: yesThe Modern Language Journal, EarlyView.
Abstract Lexical proficiency in a second language (L2) has long been effectively assessed through the measurement of various lexical indices, or textual characteristics that act as observable indicators of such conceptual categories as lexical richness, diversity, sophistication, and fluency.
Olesya Kisselev   +2 more
wiley   +1 more source

Evolutionary‐conserved RLF, a cytochrome b5‐like heme‐binding protein, regulates organ development in Marchantia polymorpha

open access: yesNew Phytologist, EarlyView.
Summary In Arabidopsis thaliana, REDUCED LATERAL ROOT FORMATION (RLF), a cytochrome b5‐like heme‐binding domain (Cytb5‐HBD) protein, is necessary for proper lateral root (LR) formation. Whereas the other Cytb5‐HBD proteins in A. thaliana regulate different metabolic reactions, RLF is unique as it specifically regulates organ development.
Kentaro P. Iwata   +8 more
wiley   +1 more source

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