Results 151 to 160 of about 38,611 (276)

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi   +19 more
wiley   +1 more source

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF‐β/Smad Signalling Pathway

open access: yesCell Proliferation, EarlyView.
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Han Zhang   +6 more
wiley   +1 more source

Do temporary changes in earnings caused by mean reversion affect firms’ refinancing decisions?

open access: yesJournal of Financial Research, EarlyView.
Abstract We develop a dynamic two‐stage trade‐off model with refinancing when earnings are mean reverting. Our model predicts a negative relation between profitability and leverage at refinancing due to conservative debt increases. With multiple rounds of refinancing, the leverage–profitability relation may turn positive when firms have substantial ...
Elettra Agliardi   +3 more
wiley   +1 more source

Explicit minimisers for anisotropic Riesz energies. [PDF]

open access: yesCalc Var Partial Differ Equ
Frank RL   +5 more
europepmc   +1 more source

A signaling pathway mediating abscisic acid‐induced jasmonic acid biosynthesis during strawberry ripening

open access: yesJournal of Integrative Plant Biology, EarlyView.
During strawberry ripening, abscisic acid signaling activates SnRK2.6, which phosphorylates and degrades the JAZ12 repressor. This releases the MYC2 transcription factor, directly activating jasmonic acid biosynthesis genes. The resulting jasmonic acid accumulation drives aroma production, thereby coupling ripening with scent formation through this ...
Kenan Jia   +10 more
wiley   +1 more source

Epigenetic control of metabolic identity across cell types. [PDF]

open access: yesBMC Genomics
Pacheco MP   +8 more
europepmc   +1 more source

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