Results 91 to 100 of about 30,982 (276)

Modifiable Dietary Habits, Inflammatory Mediation, and Senile Cataract: Unraveling Causality via Mendelian Randomization

open access: yesFood Science &Nutrition, Volume 13, Issue 12, December 2025.
This Mendelian randomization study indicates that specific drinking habits influence the risk of senile cataract (SC) through inflammatory modulation. Genetic analyses revealed that, compared to consuming alcohol apart from meals, alcohol intake aligned with meals reduces the risk of SC among current drinkers, partially through lowered inflammation ...
Jian Deng   +6 more
wiley   +1 more source

Risk Factors for Cardiovascular and Metabolic Disease: Integrating Traditional and Novel Paradigms

open access: yesiNew Medicine, Volume 1, Issue 1, December 2025.
ABSTRACT Cardiovascular and metabolic diseases (CVMD), encompassing atherosclerotic cardiovascular disease (ASCVD), heart failure, obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD), remain the leading global cause of morbidity and mortality.
Zhihua Wang   +3 more
wiley   +1 more source

Homocysteine and cardiovascular disease

open access: yesحیات, 2000
Hyperhomocysteinemia is a condition which , in the absence of kidney disease , indicates a disturpted sulfur amino acid metabolism , either because of vitamin deficiency (folate , B12 and B6 ) or a genetic defect. Epidemiologicevidence suggests that mild
p yavari
doaj  

Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis [PDF]

open access: yes, 2001
Numerous clinical and epidemiological studies have identified elevated homocysteine levels in plasma as a risk factor for atherosclerotic vascular disease and thromboembolism.
Arias, R. (Roberto)   +8 more
core   +1 more source

Mechanism of Hypoxia‐Induced HMGB1 Regulating NLRP3 Inflammasome/Caspase‐1 Pathway‐Mediated Pyroptosis in Myocardial Ischemia Reperfusion Injury Through the Nrf2/HO‐1 Pathway

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
Hypoxia induces HMGB1's nucleus‐to‐cytoplasm translocation, which binds to Nrf2 to repress Nrf2 nuclear translocation to suppress Nrf2/HO‐1 activation to promote NLRP3 inflammasome/Caspase‐1‐mediated pyroptosis, thereby exacerbating MIRI. ABSTRACT Objective Myocardial ischemia–reperfusion injury (MIRI) represents an inevitable risk event for acute ...
Fuzhen Zheng   +7 more
wiley   +1 more source

Economic Impact of Hyperhomocysteinemia in Switzerland [PDF]

open access: yes, 2018
Summary: Since more than 20 years elevated homocysteine plasma levels have been associated with an elevated cardiovascular risk. It can be assumed that approx. 5-7% of the Swiss population suffers from hyperhomocysteinemia.
Käser, Andreas   +2 more
core  

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health

open access: yesJournal of Neurochemistry, Volume 169, Issue 12, December 2025.
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Osmar Vieira Ramires Júnior   +5 more
wiley   +1 more source

Hyperhomocysteinemia - An unidentified risk factor for stroke in our population [PDF]

open access: yes, 2015
Introduction: Various studies show that moderate elevation of plasma homocysteine level has been associated with increased risk for cardiovascular and cerebrovascular disease.
Alvi, Shafaq   +3 more
core   +1 more source

Serum Homocysteine Levels and its Methylenetetrahydrofolate Gene (MTHFR) C677t Polymorphism in Patients with Hemodialysis [PDF]

open access: yes, 2017
Homocysteine plays an important role in cardiovascular disease as an independent risk factor, especially in patients with renal insufficiency. The present study aimed to determine whether Hcy levels, or those of its C677T polymorphism, were associated ...
ALMONACID URREGO, CARMEN CECILIA   +17 more
core   +1 more source

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