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Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

International Journal of Molecular Sciences, 2021
The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine (
Giovanna Mottola, Julien Fromonot, Pierre Deharo   +2 more
exaly   +2 more sources

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Hyperhomocysteinemia in Cardiovascular Diseases: Revisiting Observational Studies and Clinical Trials

Thrombosis and Haemostasis, 2022
Thromboembolic manifestations are relativement frequent in patients with intermediate/severe hyperhomocysteinemia (> 30 µmol/L) related to inherited disorders and deficiencies in vitamin B12 and folate.
J. Guéant, R. Guéant-Rodriguez, A. Oussalah, S. Zuily, I. Rosenberg   +4 more
semanticscholar   +1 more source

Hyperhomocysteinemia and cardiovascular diseases.

Annales de Biologie Clinique, 2022
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the diet, but rather synthesized as an intermediate metabolite in the methionine cycle.
R. Guieu, J. Ruf, G. Mottola
semanticscholar   +1 more source

Causes of hyperhomocysteinemia and its pathological significance

Archives of Pharmacal Research, 2018
Youngjoo Kwon
exaly   +2 more sources

Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia

International Journal of Molecular Sciences, 2019
Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer.
Joanna Perła-Kaján, Hieronim Jakubowski   +1 more
exaly   +2 more sources

Hyperhomocysteinemia as a Risk Factor for Vascular Contributions to Cognitive Impairment and Dementia

Frontiers in Aging Neuroscience, 2018
Behind only Alzheimer’s disease, vascular contributions to cognitive impairment and dementia (VCID) is the second most common cause of dementia, affecting roughly 10–40% of dementia patients. While there is no cure for VCID, several risk factors for VCID,
Brittani R Price, Donna M Wilcock, Erica M Weekman   +2 more
exaly   +2 more sources

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice

Laboratory Investigation, 2017
Hyperhomocysteinemia (HHcy) has been shown to promote vascular inflammation and atherosclerosis, but the underlying mechanisms remain largely unknown.
Xiao-Ying Lou, Dong Fan, Hongmei Tan
exaly   +2 more sources

Homocysteine, hyperhomocysteinemia and H-type hypertension.

European Journal of Preventive Cardiology
Homocysteine (Hcy) is a sulfur-containing nonessential amino acid derived from the intermediate metabolites of methionine. Methionine is obtained from dietary proteins, such as poultry, meat, eggs, seafood, and dairy products.
Dong-Feng Wu, Rui-Xing Yin, Jin-Long Deng   +2 more
semanticscholar   +1 more source

Prevalence and clinical demography of hyperhomocysteinemia in Han Chinese patients with schizophrenia

European Archives of Psychiatry and Clinical Neuroscience, 2020
Yating Yang, Juan Wang, Zulun Xiong, Xianhu Yao, Yulong Zhang, Xiaoshuai Ning, Y. Zhong, Zhiwei Liu, Yelei Zhang, Tongtong Zhao, Lei Xia, Kai Zhang, Huanzhong Liu   +12 more
semanticscholar   +1 more source