Results 191 to 200 of about 89,537 (288)

Metabolic dysfunction‐associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: A deadly triad

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major global cause of liver disease, driven by obesity and insulin resistance (IR). IR promotes hepatic lipid accumulation, inflammation and mitochondrial dysfunction, accelerating MASLD progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Alfredo Caturano, Enes Erul, Roberto Nilo, Davide Nilo, Vincenzo Russo, Luca Rinaldi, Carlo Acierno, Erman Akkus, Katerina Koudelkova, Federica Cerini, Alessandro Rizzo, Ferdinando Carlo Sasso, Leonilde Bonfrate, Antonio Giordano, Hatime Arzu Yaşar, Caterina Conte   +15 more
wiley   +1 more source

Growth Without GH: A Case Series and Literature Review. [PDF]

J Clin Med
Bilha SC, Preda C, Leustean L, Akad N, Matei A, Ungureanu MC.   +5 more
europepmc   +1 more source

Effects of Insulin on Prenylation as a Mechanism of Potentially Detrimental Influence of Hyperinsulinemia* [PDF]

, 2000
Boris Draznin, Philip D.G. Miles, Yolanta T. Kruszynska, Jerrold M. Olefsky, Jacob E. Friedman, Inga Golovchenko, Richard Stjernholm, Kei Wall, Marc L. Reitman, Domenico Accili, Robert C. Cooksey, Donald A. McClain, Marc L. Goalstone   +12 more
openalex   +1 more source

Lipidomic profiling unveils sex differences in diabetes risk: Implications for precision medicine

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
This study uncovered sex‐specific metabolic and lipidomic signatures of prediabetes. In PREVADIAB2 (n = 953), clustering by insulin traits revealed four phenotypes. Lipidomics showed women enriched in dihydroceramides and sphingomyelins, while men displayed a higher ceramide/sphingomyelin ratio. These sex‐metabolic phenotypes expose distinct lipidomes,
Ana F. Pina, Maria João Meneses, Fabrizia Carli, Rogério T. Ribeiro, Luís Gardete‐Correia, José M. Boavida, João F. Raposo, Amalia Gastaldelli, M. Paula Macedo   +8 more
wiley   +1 more source

A Snapshot of Cardiometabolic Health in Young Adults without Obesity Reveals High Rates of Dysglycemia. [PDF]

Diabetes Metab J
Kuriel V, Betik AC, Connor T, Hamley S, Ang T, Kloosterman D, Mason SA, Morales-Scholz MG, Howlett KF, Dao GM, Kowalski GM, Bruce CR, Shaw CS.   +12 more
europepmc   +1 more source

Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels [PDF]

, 2016
Johan Staaf, S. J. Kumari A. Ubhayasekera, Ernest Sargsyan, Azazul Chowdhury, Hjalti Kristinsson, Hannes Manell, Jonas Bergquist, Anders Forslund, Peter Bergsten   +8 more
openalex   +1 more source

Assessing the interaction of the UCP system and fatty acids on epicardial adipose tissue mitochondrial respiration

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Epicardial adipose tissue (EAT) demonstrates higher mitochondrial activity than subcutaneous fat (SAT), particularly in NADH‐ and FAO‐linked oxidative phosphorylation (OXPHOS). While EAT expresses more UCP1, its inhibition by GDP minimally affects respiration, especially in FAO pathways, suggesting UCP1‐independence. Diabetes mellitus (DM) and coronary
Diana Santos, Ana Burgeiro, Ana Catarina R. G. Fonseca, Cândida Dias, Teresa Cunha‐Oliveira, Aryane Oliveira, João Laranjinha, António Canotilho, Gonçalo Coutinho, David Prieto, Pedro Antunes, Manuel Antunes, Eugenia Carvalho   +12 more
wiley   +1 more source

Modeling chaotic diabetes systems using fully recurrent neural networks enhanced by fractional-order learning. [PDF]

Sci Rep
Mostafa E, Mahmoud TA, El-Brawany MA.
europepmc   +1 more source

Hyperinsulinemia is associated with menstrual irregularity and altered serum androgens in Pima Indian women [PDF]

, 1994
Daniel J. Weiss, Marie‐Aline Charles, Andrea Dunaif, Donna E. Prior, Stephen Lillioja, William C. Knowler, William H. Herman   +6 more
openalex   +1 more source

The fat‐heart entanglement and the role of ‘osteopontin mechanics’ in cardiometabolic senescence

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Abstract Background Residual cardiovascular (CV) risk persists despite therapeutic advances. Obesity is heterogeneous, and visceral adipose tissue (VAT) dysfunction (‘adiposopathy’) complicates risk stratification. Osteopontin (OPN) is a pleiotropic mediator implicated in VAT inflammation, senescence‐associated pathways, atherosclerosis and myocardial ...
Cristina Michelauz, Fabrizio Montecucco, Luca Liberale, Federico Carbone   +3 more
wiley   +1 more source