Results 181 to 190 of about 10,576 (237)
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Trends in Endocrinology & Metabolism, 1999
Hypoglycemia as a result of hyperinsulinism in the newborn (HI) is a clinically heterogeneous entity that presents a diagnostic and therapeutic challenge to the treating physician. Recent discoveries have shown that mutations in four different beta-cell genes cause HI.
, Glaser, , Landau, , Permutt
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Hypoglycemia as a result of hyperinsulinism in the newborn (HI) is a clinically heterogeneous entity that presents a diagnostic and therapeutic challenge to the treating physician. Recent discoveries have shown that mutations in four different beta-cell genes cause HI.
, Glaser, , Landau, , Permutt
openaire +4 more sources
The Use of Lanreotide in the Treatment of Congenital Hyperinsulinism
Journal of Clinical Endocrinology and Metabolism, 2022 CONTEXT Congenital hyperinsulinism (HI) results in severe, persistent hypoglycemia and is associated with high risk of neurodevelopmental deficits. Sixty percent of HI cases are unresponsive to diazoxide, the only FDA-approved drug.
Katherine Lord +2 more
exaly +2 more sources
Human Mutation, 2020 The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP‐sensitive potassium channel, a key component of the glucose‐stimulated insulin secretion ...
Elisa De Franco +2 more
exaly +2 more sources
Congenital Hyperinsulinism: An Historical Perspective
Hormone Research in Paediatrics, 2022Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in neonates, infants, and children. Since the first case descriptions in the 1950s, the field has advanced significantly.
P. Thornton +2 more
semanticscholar +1 more source
Congenital hyperinsulinism: recent updates on molecular mechanisms, diagnosis and management
Journal of Pediatric Endocrinology & Metabolism (JPEM), 2021Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe hypoglycaemia in the neonatal period and early childhood. Mutations in 16
D. Giri, Katherine Hawton, S. Senniappan
semanticscholar +1 more source
THE ENCEPHALOPATHY OF HYPERINSULINISM
Annals of Internal Medicine, 19491. A case of severe hyperinsulinism in a juvenile diabetic is reported in which unconsciousness was produced for over 72 hours. 2. Emphasis is placed on the unreliability of the urine as an initial diagnostic indicator in coma seen during the course of extremely labile diabetes mellitus. 3. Globin insulin, in large doses, is shown to have a cumulative,
S K, FINEBERG, A, ALTSCHUL
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Early Human Development, 2010
Congenital hyperinsulinism (CHI or HI) is a condition leading to recurrent hypoglycemia due to an inappropriate insulin secretion by the pancreatic islet beta cells. HI has two main characteristics: a high glucose requirement to correct hypoglycemia and a responsiveness of hypoglycemia to exogenous glucagon.
Jean-Baptiste, Arnoux +15 more
openaire +2 more sources
Congenital hyperinsulinism (CHI or HI) is a condition leading to recurrent hypoglycemia due to an inappropriate insulin secretion by the pancreatic islet beta cells. HI has two main characteristics: a high glucose requirement to correct hypoglycemia and a responsiveness of hypoglycemia to exogenous glucagon.
Jean-Baptiste, Arnoux +15 more
openaire +2 more sources
Pediatric Annals, 2017
Congenital hyperinsulinism is a rare disorder that commonly presents in the immediate postnatal period as persistent hypoglycemia. The condition is frequently resistant to medical therapies, and the genetic mutations implicated in the disorder can be predictive of response to therapy.
Elena, Minakova, Alison, Chu
openaire +2 more sources
Congenital hyperinsulinism is a rare disorder that commonly presents in the immediate postnatal period as persistent hypoglycemia. The condition is frequently resistant to medical therapies, and the genetic mutations implicated in the disorder can be predictive of response to therapy.
Elena, Minakova, Alison, Chu
openaire +2 more sources
NeoReviews, 2021
Hyperinsulinemic hypoglycemia (HH) is fairly common in neonates, particularly those born to diabetic mothers and those who are either large or small for gestational age. Immediate management of the disease focuses on achieving normoglycemia through frequent high-calorie feedings and/or intravenous glucose administration.
openaire +2 more sources
Hyperinsulinemic hypoglycemia (HH) is fairly common in neonates, particularly those born to diabetic mothers and those who are either large or small for gestational age. Immediate management of the disease focuses on achieving normoglycemia through frequent high-calorie feedings and/or intravenous glucose administration.
openaire +2 more sources
New England Journal of Medicine, 1933
Hyperinsulinism is the term suggested by Harris 1 in 1924 in explanation of spontaneous hypoglycemia. If there is insufficient insulin, hyperglycemia and diabetes mellitus develop; if insulin is excessive, hypoglycemia develops, with the characteristic symptoms seen after an overdose of insulin.
E. STARR JUDD +2 more
+4 more sources
Hyperinsulinism is the term suggested by Harris 1 in 1924 in explanation of spontaneous hypoglycemia. If there is insufficient insulin, hyperglycemia and diabetes mellitus develop; if insulin is excessive, hypoglycemia develops, with the characteristic symptoms seen after an overdose of insulin.
E. STARR JUDD +2 more
+4 more sources