Results 221 to 230 of about 14,238 (246)
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Fetal hyperinsulinism in anencephaly
American Journal of Obstetrics and Gynecology, 1989Insulin was measured in the blood collected in utero from three midtrimester anencephalic fetuses. The hyperinsulinism found could be due to an underutilization of glucose in the absence of most of the brain and could be responsible for the relatively normal growth in anencephaly despite the absence of the hypothalamohypophysial axis.
Hubinont, C +3 more
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Seminars in Fetal and Neonatal Medicine, 2005
Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic aetiology and response to medical therapy. The clinical heterogeneity may range from severe life-threatening disease to very mild clinical symptoms.
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Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic aetiology and response to medical therapy. The clinical heterogeneity may range from severe life-threatening disease to very mild clinical symptoms.
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New England Journal of Medicine, 1971
IN attempting to evolve a unitary concept to explain the metabolic and clinical aberrations of diabetes mellitus, one is hard put to find a single defect that will satisfy all the known facts.
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IN attempting to evolve a unitary concept to explain the metabolic and clinical aberrations of diabetes mellitus, one is hard put to find a single defect that will satisfy all the known facts.
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Hyperinsulinism in syndromal disorders
Acta Paediatrica, 2001Analysis of a German database comprising a total of 54 patients with neonatal manifestations of persistent hyperinsulinism revealed 5 patients in whom hyperinsulinism was associated with additional clinical symptoms, suggesting an underlying syndromal disorder.
René Santer +5 more
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Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism
Hormone Research in Paediatrics, 2019Introduction: Diazoxide is the first line and only Federal Drug Agency approved pharmacological agent for the treatment of hyperinsulinism. Its use has increased over the years to include patients with various genetic forms of hyperinsulinism, perinatal ...
P. Thornton +4 more
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Hyperinsulinism in Infancy and Childhood
1984Hypoglycaemia is the most common metabolic abnormality in childhood. In addition to the high prevalence of the disorder, hypoglycaemia is of particular importance for paediatricians since it is a potent cause of severe neurological damage when it is persistent or recurrent.
Albert Aynsley-Green, G. Soltész
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Hyperinsulinism and Cerebral Microangiopathy
Stroke, 1996Background and Purpose High insulin levels are a recognized risk factor for atherosclerosis. Microvascular endothelium is more susceptible to metabolic and mitogenic effects of insulin than large-vessel endothelium. Besides their atherogenic effect, high insulin levels impair fibrinolysis by enhancing plasminogen activator ...
Darius G. Nabavi +6 more
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HYPERINSULINISM AND DYSINSULINISM [PDF]
JAMA: The Journal of the American Medical Association, 1924 Diabetes, of which hyperglycemia is a manifestation, is essentially a condition due to a deficient secretion of insulin by the islands of Langerhans; and, according to modern medical nomenclature, should be called hypo-insulinism. Diabetes, or hypo-insulinism, therefore, bears the same relation to the internal secretion of the pancreas that myxedema ...
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CLINICAL ASPECTS OF HYPERINSULINISM
Journal of the American Medical Association, 1956• Hyperinsulinism in forms satisfying rigid diagnostic criteria was found in 91 cases. The attacks must be associated with exercise or fasting, the blood sugar level during an attack must be less than 50 mg. per 100 cc., and the attack must be relieved by the administration of sugar.
Edward H. Rynearson +2 more
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Hyperinsulinism in Developmental Syndromes
2009Hyperinsulinism is a cause of recurrent and severe hypoglycaemia in the newborn and infancy period. Several developmental genetic syndromes are associated with hyperinsulinism. The underlying molecular mechanisms that lead to hyperinsulinaemic hypoglycaemia in most of these syndromes are unclear.
Ritika R. Kapoor +2 more
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