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Congenital Hyperinsulinism: An Historical Perspective
Hormone Research in Paediatrics, 2022Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in neonates, infants, and children. Since the first case descriptions in the 1950s, the field has advanced significantly.
P. Thornton +2 more
semanticscholar +1 more source
Congenital hyperinsulinism: recent updates on molecular mechanisms, diagnosis and management
Journal of Pediatric Endocrinology & Metabolism (JPEM), 2021Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe hypoglycaemia in the neonatal period and early childhood. Mutations in 16
D. Giri, Katherine Hawton, S. Senniappan
semanticscholar +1 more source
THE ENCEPHALOPATHY OF HYPERINSULINISM
Annals of Internal Medicine, 19491. A case of severe hyperinsulinism in a juvenile diabetic is reported in which unconsciousness was produced for over 72 hours. 2. Emphasis is placed on the unreliability of the urine as an initial diagnostic indicator in coma seen during the course of extremely labile diabetes mellitus. 3. Globin insulin, in large doses, is shown to have a cumulative,
S. K. Fineberg, Alexander Altschul
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Hyperinsulinism in the Neonate
Clinics in Perinatology, 2018Hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants. Prompt recognition and treatment, independent of whether infants have transient or permanent HI, are essential to decrease risk of neurologic damage. The most common form of congenital HI is due to inactivating mutations of the β-cell ATP-sensitive potassium (KATP) channel
Katherine Lord +2 more
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Journal of Paediatrics and Child Health, 1989
Abstract Five infants with persistent hypoglycaemia due to hyperinsulinism were reported. Provocative tests for insulin release were unhelpful. Diazoxide was useful in the treatment of three patients but many side‐effects were observed. These included petechial rash, hypertrichosis, acute renal failure, fluid retention and cardiac failure.
E. C. L. Yu +4 more
openaire +3 more sources
Abstract Five infants with persistent hypoglycaemia due to hyperinsulinism were reported. Provocative tests for insulin release were unhelpful. Diazoxide was useful in the treatment of three patients but many side‐effects were observed. These included petechial rash, hypertrichosis, acute renal failure, fluid retention and cardiac failure.
E. C. L. Yu +4 more
openaire +3 more sources
Early Human Development, 2010
Congenital hyperinsulinism (CHI or HI) is a condition leading to recurrent hypoglycemia due to an inappropriate insulin secretion by the pancreatic islet beta cells. HI has two main characteristics: a high glucose requirement to correct hypoglycemia and a responsiveness of hypoglycemia to exogenous glucagon.
Jean-Baptiste, Arnoux +15 more
openaire +2 more sources
Congenital hyperinsulinism (CHI or HI) is a condition leading to recurrent hypoglycemia due to an inappropriate insulin secretion by the pancreatic islet beta cells. HI has two main characteristics: a high glucose requirement to correct hypoglycemia and a responsiveness of hypoglycemia to exogenous glucagon.
Jean-Baptiste, Arnoux +15 more
openaire +2 more sources
Hyperinsulinism and hyperammonaemia
Journal of Inherited Metabolic Disease, 1998Hyperinsulinism and hyperammonaemia L . Al-Shamsan1, M. Al-Essa2, A. Al-Mutair2, A. Al-Ashwal2, N. Sakati2 and P. T . Ozand2,3* 1 Department of Pediatrics, King Fahad National Guard Hospital, Riyadh ; 2 Department of Pediatrics, King Faisal Specialist Hospital and Research Centre ; 3 Department of Biological and Medical Research, King Faisal Specialist
Nadia Sakati +5 more
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NeoReviews, 2021
Hyperinsulinemic hypoglycemia (HH) is fairly common in neonates, particularly those born to diabetic mothers and those who are either large or small for gestational age. Immediate management of the disease focuses on achieving normoglycemia through frequent high-calorie feedings and/or intravenous glucose administration.
openaire +2 more sources
Hyperinsulinemic hypoglycemia (HH) is fairly common in neonates, particularly those born to diabetic mothers and those who are either large or small for gestational age. Immediate management of the disease focuses on achieving normoglycemia through frequent high-calorie feedings and/or intravenous glucose administration.
openaire +2 more sources