Results 261 to 270 of about 20,640 (292)
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Clinics in Perinatology, 1998
Hyperinsulinism is the most frequent cause of severe, persistent hypoglycemia in neonates and young infants. Timely diagnosis and aggressive treatment are necessary to prevent long-term neurologic sequelae. This article explores the latest advances in the understanding of the pathophysiology of this disorder at the molecular and cellular level.
V M, Schwitzgebel, S E, Gitelman
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Hyperinsulinism is the most frequent cause of severe, persistent hypoglycemia in neonates and young infants. Timely diagnosis and aggressive treatment are necessary to prevent long-term neurologic sequelae. This article explores the latest advances in the understanding of the pathophysiology of this disorder at the molecular and cellular level.
V M, Schwitzgebel, S E, Gitelman
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Hyperinsulinism of the newborn
Seminars in Perinatology, 2000Neonatal hyperinsulinism (HI) is a clinical syndrome of pancreatic beta-cell dysfunction characterized by failure to suppress insulin secretion in the presence of hypoglycemia. Although rare, it is the most common cause for persistent hypoglycemia in the newborn period.
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Annals of Pharmacotherapy, 1997
In a limited number of case reports in infants, octreotide raised the blood glucose concentrations and decreased glucose requirements sufficiently to avoid pancreatectomy. This response occurs in the presence of frequent feedings and diazoxide therapy, and lasts from 1 month to greater than 5 years.
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In a limited number of case reports in infants, octreotide raised the blood glucose concentrations and decreased glucose requirements sufficiently to avoid pancreatectomy. This response occurs in the presence of frequent feedings and diazoxide therapy, and lasts from 1 month to greater than 5 years.
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A Newborn with Congenital Hyperinsulinism
Fetal and Pediatric Pathology, 2019Objective: Our aim was to describe the molecular alterations in the ABCC8 gene in a child with congenital hyperinsulinism (CHI). Methods: Genetic analysis of the ABCC8 gene of a newborn infant with congenial hyperinsulinism was obtained. Results: There were two mutations in the ABCC8 gene, c.4412delT, and c.3979G > A, indicating a compound heterozygous
Rong Ju, Peng Gou, Yufeng Xi, Yiting Du
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Genetics of Congenital Hyperinsulinism
Endocrine Pathology, 2004Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous entity and causes severe hypoglycemia in neonates and infants. The clinical heterogeneity is manifested by severity ranging from extremely severe, life-threatening disease to very mild clinical symptoms, which may even be difficult to identify.
Claudine Junien, Jean-Christophe Fournet
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The hyperinsulinism/hyperammonemia syndrome
Reviews in Endocrine and Metabolic Disorders, 2010The hyperinsulinism/hyperammonemia (HI/HA) syndrome is the second most common form of congenital hyperinsulinism (HI). Children affected by this syndrome have both fasting and protein sensitive hypoglycemia combined with persistently elevated ammonia levels.
Charles A. Stanley, Andrew A. Palladino
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New England Journal of Medicine, 1971
IN attempting to evolve a unitary concept to explain the metabolic and clinical aberrations of diabetes mellitus, one is hard put to find a single defect that will satisfy all the known facts.
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IN attempting to evolve a unitary concept to explain the metabolic and clinical aberrations of diabetes mellitus, one is hard put to find a single defect that will satisfy all the known facts.
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Fetal hyperinsulinism in anencephaly
American Journal of Obstetrics and Gynecology, 1989Insulin was measured in the blood collected in utero from three midtrimester anencephalic fetuses. The hyperinsulinism found could be due to an underutilization of glucose in the absence of most of the brain and could be responsible for the relatively normal growth in anencephaly despite the absence of the hypothalamohypophysial axis.
Hubinont, C +3 more
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Seminars in Fetal and Neonatal Medicine, 2005
Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic aetiology and response to medical therapy. The clinical heterogeneity may range from severe life-threatening disease to very mild clinical symptoms.
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Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic aetiology and response to medical therapy. The clinical heterogeneity may range from severe life-threatening disease to very mild clinical symptoms.
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Hyperinsulinism in syndromal disorders
Acta Paediatrica, 2001Analysis of a German database comprising a total of 54 patients with neonatal manifestations of persistent hyperinsulinism revealed 5 patients in whom hyperinsulinism was associated with additional clinical symptoms, suggesting an underlying syndromal disorder.
René Santer +5 more
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