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HYPERINSULINISM AND DYSINSULINISM [PDF]

JAMA: The Journal of the American Medical Association, 1924
Diabetes, of which hyperglycemia is a manifestation, is essentially a condition due to a deficient secretion of insulin by the islands of Langerhans; and, according to modern medical nomenclature, should be called hypo-insulinism. Diabetes, or hypo-insulinism, therefore, bears the same relation to the internal secretion of the pancreas that myxedema ...
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Persistent Neonatal Hyperinsulinism

Clinical Pediatrics, 1988
Over a 3-year period, the diagnosis of persistent neonatal hyperinsulinism (PNH) was made in seven infants, from an unselected cohort of 18,726 births, all of Saudi Arabian origin. Thus the incidence of PNH was one in 2,675 births. The high incidence, associated consanguinity, and occurrence in siblings suggest that PNH may be inherited as an ...
J.M. Young, Y.K. Abu-Osba, B.D. Mulhern, A.R. Sa'di, J. A. Hamdan, S. Hammoudi, Puthenpurackal M. Mathew   +6 more
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Hyperinsulinism in Developmental Syndromes

2009
Hyperinsulinism is a cause of recurrent and severe hypoglycaemia in the newborn and infancy period. Several developmental genetic syndromes are associated with hyperinsulinism. The underlying molecular mechanisms that lead to hyperinsulinaemic hypoglycaemia in most of these syndromes are unclear.
Ritika R. Kapoor, Khalid Hussain, Chela James   +2 more
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Surgical therapy of hyperinsulinism

World Journal of Surgery, 1981
AbstractOrganic hyperinsulinism is rare: the incidence is 1:100,000. In newborns, often of diabetic mothers, there may be islet cell hyperplasia. Rare cases may require partial pancreatectomy. In adults, the condition is always due to an insulinoma.
Th. Karavias, A. Hirner, B. Stallkamp, Häring R   +3 more
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The Genetics of Neonatal Hyperinsulinism

Hormone Research in Paediatrics, 2003
Congenital hyperinsulinism (CHI) is the most important cause of persistent hypoglycaemia in the neonate and infant. It is a clinically and genetically heterogeneous entity. The clinical heterogeneity is manifested by severity ranging from extremely severe life-threatening disease to very mild clinical symptoms which may even be difficult to identify ...
Jean-Christophe Fournet, Claudine Junien
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HYPERINSULINISM IN INFANTS AND CHILDREN

Pediatric Clinics of North America, 1997
Hyperinsulinism is the most common cause of hypoglycemia in early infancy. Congenital hyperinsulinism, formerly termed nesidioblastosis, is usually caused by genetic defects in beta-cell regulation, including a severe recessive disorder of the sulfonylurea receptor, a milder dominant form of hyperinsulinism, and a syndrome of hyperinsulinism plus ...
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Hyperinsulinism

Pediatrics In Review, 2019
Dominique, Long, Yasmin, Akhtar
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HYPOGLYCEMIA AND HYPERINSULINISM

Annals of Internal Medicine, 1934
Excerpt Hypoglycemia is not a disease entity, but a symptom complex, and is defined as a deficiency of blood sugar.
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Hyperinsulin Neuronopathy

Neurology, 1956
J A, BASTRON, E H, LAMBERT, D W, MULDER
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Hyperinsulinism of Infancy

2006
Hyperinsulinism of infancy (HI) is the commonest cause of recurrent and severe hypoglycaemia in the neonatal and infancy period (Hussain andAynsley-Green 2003). It is characterized by the excessive and inappropriate secretion of insulin in relation to the prevailing blood glucose concentration. HI can be either persistent or transient.
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