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Current Opinion in Pediatrics, 2013
Congenital hyperinsulinism (CHI) is a multifaceted disease and continues to be the most common cause of persistent hypoglycemia in infants. The purpose of the review is to highlight important recent developments regarding CHI.Several recent studies have highlighted the advances in medical genetics, imaging techniques, histological variety, and surgical
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Congenital hyperinsulinism (CHI) is a multifaceted disease and continues to be the most common cause of persistent hypoglycemia in infants. The purpose of the review is to highlight important recent developments regarding CHI.Several recent studies have highlighted the advances in medical genetics, imaging techniques, histological variety, and surgical
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CLINICAL ASPECTS OF HYPERINSULINISM
Journal of the American Medical Association, 1956• Hyperinsulinism in forms satisfying rigid diagnostic criteria was found in 91 cases. The attacks must be associated with exercise or fasting, the blood sugar level during an attack must be less than 50 mg. per 100 cc., and the attack must be relieved by the administration of sugar.
Edward H. Rynearson +2 more
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Rate of Serious Adverse Events Associated with Diazoxide Treatment of Patients with Hyperinsulinism
Hormone Research in Paediatrics, 2019Introduction: Diazoxide is the first line and only Federal Drug Agency approved pharmacological agent for the treatment of hyperinsulinism. Its use has increased over the years to include patients with various genetic forms of hyperinsulinism, perinatal ...
P. Thornton +4 more
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Hyperinsulinism and Cerebral Microangiopathy
Stroke, 1996Background and Purpose High insulin levels are a recognized risk factor for atherosclerosis. Microvascular endothelium is more susceptible to metabolic and mitogenic effects of insulin than large-vessel endothelium. Besides their atherogenic effect, high insulin levels impair fibrinolysis by enhancing plasminogen activator ...
Darius G. Nabavi +6 more
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Hyperinsulinism in Infancy and Childhood
1984Hypoglycaemia is the most common metabolic abnormality in childhood. In addition to the high prevalence of the disorder, hypoglycaemia is of particular importance for paediatricians since it is a potent cause of severe neurological damage when it is persistent or recurrent.
Albert Aynsley-Green, G. Soltész
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HYPERINSULINISM AND DYSINSULINISM [PDF]
JAMA: The Journal of the American Medical Association, 1924 Diabetes, of which hyperglycemia is a manifestation, is essentially a condition due to a deficient secretion of insulin by the islands of Langerhans; and, according to modern medical nomenclature, should be called hypo-insulinism. Diabetes, or hypo-insulinism, therefore, bears the same relation to the internal secretion of the pancreas that myxedema ...
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Persistent Neonatal Hyperinsulinism
Clinical Pediatrics, 1988Over a 3-year period, the diagnosis of persistent neonatal hyperinsulinism (PNH) was made in seven infants, from an unselected cohort of 18,726 births, all of Saudi Arabian origin. Thus the incidence of PNH was one in 2,675 births. The high incidence, associated consanguinity, and occurrence in siblings suggest that PNH may be inherited as an ...
J.M. Young +6 more
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Hyperinsulinism in Developmental Syndromes
2009Hyperinsulinism is a cause of recurrent and severe hypoglycaemia in the newborn and infancy period. Several developmental genetic syndromes are associated with hyperinsulinism. The underlying molecular mechanisms that lead to hyperinsulinaemic hypoglycaemia in most of these syndromes are unclear.
Ritika R. Kapoor +2 more
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The Genetics of Neonatal Hyperinsulinism
Hormone Research in Paediatrics, 2003Congenital hyperinsulinism (CHI) is the most important cause of persistent hypoglycaemia in the neonate and infant. It is a clinically and genetically heterogeneous entity. The clinical heterogeneity is manifested by severity ranging from extremely severe life-threatening disease to very mild clinical symptoms which may even be difficult to identify ...
Jean-Christophe Fournet, Claudine Junien
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Surgical therapy of hyperinsulinism
World Journal of Surgery, 1981AbstractOrganic hyperinsulinism is rare: the incidence is 1:100,000. In newborns, often of diabetic mothers, there may be islet cell hyperplasia. Rare cases may require partial pancreatectomy. In adults, the condition is always due to an insulinoma.
Th. Karavias +3 more
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