Animal Models and Experimental Medicine, EarlyView.We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu +10 more
wiley +1 more source
SCREENING FOR HYPERCHOLESTEROLEMIA IN 5 YEAR OLD CHILDREN IN SLOVENIA
Zdravniški Vestnik, 2003 Background. Cardiovascular diseases represent the most frequent cause of morbidity and mortality in developed countries. Blood cholesterol concentration influences the progression of atherosclerosis and most developed countries started programs for early
Nataša Uršič-Bratina +6 more
doaj
Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats
Animal Models and Experimental Medicine, EarlyView.Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček +3 more
wiley +1 more source
Homocysteine, MTHFR C677T gene polymorphism, folic acid and vitamin B 12 in patients with retinal vein occlusion [PDF]
, 2005 Background Many available data have suggested that hyperhomocysteinaemia, an established independent risk factor for thrombosis (arterial and venous), may be associated with an increased risk of retinal vein occlusion (RVO).
Paola Terrazzi +7 more
core +2 more sources
Factors Associated with Goal Achievement in Patients with Dyslipidemia in Primary Care
IatreiaIntroduction: Dyslipidemia promotes atherosclerotic disease. A strategy to reduce this risk is to achieve low-density lipoprotein (LDL) goals; however, these are often not attained.
Pinto-González, Gustavo +2 more
doaj +1 more source
The Clinical Spectrum and Neurodevelopmental Pathogenesis of KPTN‐Related Disorder in a Mouse Model
Annals of Neurology, EarlyView.Objective Pathogenic variants in Kaptin (KPTN) cause KPTN‐related disorder (KRD). KPTN modulates mTOR signaling activation within the KICSTOR complex in response to cellular amino acid levels. We define the clinical spectrum and investigate the developmental pathogenesis of KRD.
Lettie E. Rawlins +104 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Učinak stresnih hormona na moždanu hemodinamiku kod bolesnika s kroničnim posttraumatskim stresnim poremećajem [PDF]
, 2009 The aim of the study was to assess the possible correlation between catecholamine and cortisol levels and changes in cerebral hemodynamics in patients with chronic posttraumatic stress disorder (PTSD).
Dragutin Kadojić +10 more
core +1 more source
Are Statins Anti-Inflammatory? [PDF]
, 2012 Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expected on the basis of lipid lowering alone ...
Blake, Gavin J., Ridker, Paul M.
core +1 more source
Clot Composition Profiling in Large Vessel Occlusion Stroke Via Radiomics
Annals of Neurology, EarlyView.Objective Clot composition may offer insights into the mechanism of ischemic stroke. Radiomics, a noninvasive imaging technique, enables tissue characterization through radiomic features (RFs). We aimed to evaluate clot composition using radiomics on non‐contrast computed tomography (NCCT).
Andres Gudino +23 more
wiley +1 more source