Results 71 to 80 of about 990,113 (271)

Clinical, Anthropometric and Biochemical Characteristics of Patients with or without Genetically Confirmed Familial Hypercholesterolemia

Arquivos Brasileiros de Cardiologia
Background: Familial hypercholesterolemia (FH) is a common autosomal dominant disorder, characterized by a high level of low-density lipoprotein cholesterol (LDL-C) and a high risk of premature cardiovascular disease. Objective: To evaluate clinical and
Andrea De Lorenzo, Juliana Duarte Lopes da Silva, Cinthia E. James, Alexandre C. Pereira, Annie Seixas Bello Moreira   +4 more
doaj   +1 more source

CR Structures and Twisting Vacuum Spacetimes with Two Killing Vectors and Cosmological Constant: Type II and More Special [PDF]

Class. Quantum Grav. (2013) 30 115006, 2013
Based on the CR formalism of algebraically special spacetimes by Hill, Lewandowski and Nurowski, we derive a nonlinear system of two real ODEs, of which the general solution determines a twisting type II (or more special) vacuum spacetime with two Killing vectors (commuting or not) and at most seven real parameters in addition to the cosmological ...
arxiv   +1 more source

A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia [PDF]

, 2009
Numerous single nucleotide polymorphisms (SNPs) have been found in recent genome wide association studies (GWAS) to be associated with subtle plasma triglyceride (TG) variation in normolipidemic subjects.
Anand, Aulchenko, Boright, Brooke A. Kennedy, Dammerman, Fredrickson, Goldstein, Guang Yong Zou, Hardy, Hegele, Hegele, Hegele, Hegele, Henian Cao, Hirschhorn, Jian Wang, Kathiresan, Kathiresan, Kathiresan, Kraft, Lusis, Matthew R. Ban, Murray W. Huff, Neil Hsueh, Rader, Robert A. Hegele, Sabatti, Salim Yusuf, Sandhu, Saxena, Sonia Anand, Wallace, Wang, Wang, Wang, Willer, Yuan   +36 more
core   +2 more sources

Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications

BioFactors, Volume 50, Issue 5, Page 922-956, September/October 2024.
High‐density lipoproteins are versatile lipoprotein nanoparticles that have pleotropic functions in regulating lipid metabolism, innate immunity, and protection of cardiovascular system. They comprise of several proteins among which 15 apolipoproteins are the major proteins, with diverse functions.
Aishwarya Sudam Bhale, Olivier Meilhac, Christian Lefebvre d'Hellencourt, Mookambeswaran A. Vijayalakshmi, Krishnan Venkataraman   +4 more
wiley   +1 more source

Real‐world effectiveness of monoclonal antibody inhibitors of PCSK9 in patients with heterozygous familial hypercholesterolemia: A retrospective cohort study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 44, Issue 9, Page 730-737, September 2024.
Abstract Background Heterozygous familial hypercholesterolemia (HeFH) is a genetic condition that is associated with a high risk of atherosclerotic cardiovascular disease (ASCVD) due to elevated lipid levels. Proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibody inhibitors have been shown to reduce low‐density lipoprotein ...
Rebecca Siemens, Mark Pryjma, Susan Buchkowsky, Arden R. Barry   +3 more
wiley   +1 more source

CME liftoff with high-frequency fragmented type II burst emission [PDF]

, 2008
Aims: Solar radio type II bursts are rarely seen at frequencies higher than a few hundred MHz. Since metric type II bursts are thought to be signatures of propagating shock waves, it is of interest to know how these shocks, and the type II bursts, are formed. In particular, how are high-frequency, fragmented type II bursts created?
arxiv   +1 more source

Dysbetalipoproteinaemia-clinical and pathophysiological features [PDF]

, 2016
Objectives. Dysbetalipoproteinaemia (type III hyperlipidaemia, broad-beta disease) is a highly atherogenic genetic disorder of lipoprotein metabolism.
Blom, D J, Byrnes, P, Jones, S, Marais, AD   +3 more
core   +1 more source

Low Lipoprotein(a) Concentration Is Associated with Cancer and All-Cause Deaths: A Population-Based Cohort Study (The JMS Cohort Study) [PDF]

, 2012
Background: Experimental studies support the anti-neoplastic effect of apo(a), but several clinical studies have reported contradictory results. The purpose of this study was to determine whether a low lipoprotein(a) [Lp(a)] concentration is related to ...
A Bennet, A Gaw, A Kurup, A Noma, AA Ariyo, AC Kuesel, B Smolders, BG Nordestgaard, BR Jaeger, D Aras, DN Samonakis, E Kökoğlu, E Merki, G Lippi, G Lippi, G Pepe, German Malaga, HH Yang, HK Yu, HK Yu, I Ikai, J Danesh, J Hoover-Plow, J Thillet, JL Jenner, JM Halton, JP Fine, JS Kim, JW Van Wersch, K Kiyosawa, K Lee, Kazunori Kayaba, Ken-ichi Nakahara, KG Parhofer, KL Chien, L Denti, LC Wright, M Motta, M Sawabe, Makiko Naka Mieno, ML Wahl, Motoji Sawabe, N Hirose, N Nago, Noriko Tanaka, RJ Gray, S Durrleman, S Erqou, S Ishikawa, S Ishikawa, Satoru Matsushita, Shizukiyo Ishikawa, T Ohira, VN Trieu, Y Arai, Y Yano, ZF Yi   +56 more
core   +3 more sources

Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study

Journal of Clinical Apheresis, Volume 39, Issue 4, August 2024.
Abstract Background Peripheral artery disease (PAD) in hemodialysis (HD) patients has a significant social impact due to its prevalence, poor response to standard therapy and dismal prognosis. Rheopheresis is indicated by guidelines for PAD treatment. Materials and Methods Twenty‐five HD patients affected by PAD stage IV Lerichè‐Fontaine and ischemic ...
Claudia Altobelli, Filippo Carone Fabiani, Pietro Anastasio, Corrado Pluvio, Emanuela de Pascale, Luigi Vernaglione, Giuseppe Gernone, Marina Di Luca, Veronica Bertuzzi, Paola Brescia, Pierpaolo Toffoletto, Mario D'Arezzo, Maddalena Brustia, Andreana De Mauri, Doriana Chiarinotti, Carmelo Loschiavo, Matteo Grecò, Filomena D'Elia, Maria Anna Gallo, Giovanni Tarroni, Lorenzo Di Liberato, Alessandra F Perna, Giovambattista Capasso, Giovanna Capolongo   +23 more
wiley   +1 more source

Type-II Matrices and Combinatorial Structures [PDF]

arXiv, 2007
Type-II matrices are a class of matrices used by Jones in his work on spin models. In this paper we show that type-II matrices arise naturally in connection with some interesting combinatorial and geometric structures.
arxiv