Results 81 to 90 of about 990,113 (271)

Molecular analysis of three known and one novel LPL variants in patients with type I hyperlipoproteinemia. [PDF]

, 2017
Background and aims Type I hyperlipoproteinemia, also known as familial chylomicronemia syndrome (FCS), is a rare autosomal recessive disorder caused by variants in LPL, APOC2, APOA5, LMF1 or GPIHBP1 genes.
A. Caddeo, A. Pujia, C. Pirazzi, C. Russo, J. Sandstedt, K. Sasidharan, P. Pingitore, R.M. Mancina, S. Maurotti, S. Romeo, T. Montalcini, T.P. Leren   +11 more
core   +1 more source

A Randomized, Double‐Blind, Placebo‐Controlled, Phase 1 Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Single Vaccination of Ad26.RSV.preF‐Based Regimen in Japanese Adults Aged 60 Years and Older

Influenza and Other Respiratory Viruses, Volume 18, Issue 6, June 2024.
ABSTRACT Background Respiratory syncytial virus (RSV) is increasingly recognized as a significant cause of lower respiratory tract disease (LRTD) in older adults. The Ad26.RSV.preF/RSV preF protein vaccine demonstrated protective efficacy against RSV related LRTD in a Phase 2b study in the United States.
Takashi Eto, Yusuke Okubo, Atsushi Momose, Hiroshi Tamura, Richuan Zheng, Benoit Callendret, Arangassery Rosemary Bastian, Christy A. Comeaux   +7 more
wiley   +1 more source

Complex Phenotype of Hypercholesterolemia in a Family with Both ABCG8 and APOB Mutations [PDF]

, 2021
Familial hypercholesterolemia is a common genetic hypercholesterolemia caused by mutations in LDLR, APOB and PCSK9 that leads to premature atherosclerosis.
Alves, AC, Bourbon, M, Ferreira, AC, Medeiros, AM, Padeira, G   +4 more
core   +1 more source

Sanghuangporus vaninii extract ameliorates hyperlipidemia in rats by mechanisms identified with transcriptome analysis

Food Science &Nutrition, Volume 12, Issue 5, Page 3360-3376, May 2024.
Extracts of Sanghuangporus vaninii can relieve hyperlipidemia in rats. The results of transcriptomic analysis indicated that S. vaninii extract can activate the AMPK signaling pathway, which subsequently promotes the metabolism of lipids and inhibits the biosynthesis of cholesterol, meanwhile facilitating the excretion of cholesterol, exciting the ...
Ning Gao, Yuanzhen Liu, Guangjie Liu, Bo Liu, Yupeng Cheng   +4 more
wiley   +1 more source

Type II Multi-indexed Little $q$-Jacobi and Little $q$-Laguerre Polynomials [PDF]

J. Math. Phys. 66 (2025) 013506 (16pp)
For the isospectral Darboux transformations of the discrete quantum mechanics with real shifts, there are two methods: type I and type II constructions. Based on the type I construction, the type I multi-indexed little $q$-Jacobi and little $q$-Laguerre orthogonal polynomials were presented in J. Phys. {\bf A50} (2017) 165204.
arxiv   +1 more source

Chronic heart failure induces early defenestration of liver sinusoidal endothelial cells (LSECs) in mice

Acta Physiologica, Volume 240, Issue 5, May 2024.
Abstract Aim Chronic heart failure (CHF) is often linked to liver malfunction and systemic endothelial dysfunction. However, whether cardio‐hepatic interactions in heart failure involve dysfunction of liver sinusoidal endothelial cells (LSECs) is not known.
Kamila Wojnar‐Lason, Urszula Tyrankiewicz, Agnieszka Kij, Anna Kurpinska, Patrycja Kaczara, Grzegorz Kwiatkowski, Natalia Wilkosz, Magdalena Giergiel, Marta Stojak, Marek Grosicki, Tasnim Mohaissen, Agnieszka Jasztal, Zuzanna Kurylowicz, Marek Szymonski, Izabela Czyzynska‐Cichon, Stefan Chlopicki   +15 more
wiley   +1 more source

Apolipoprotein E isoforms and their Cys‐thiol modifications impact LRP1‐mediated metabolism of triglyceride‐rich lipoproteins

FEBS Letters, Volume 598, Issue 3, Page 347-362, February 2024.
The current study offers a novel perspective on the physiological role of apolipoprotein (apo) E in lipid metabolism. The redox status of Cys‐thiol in the apoE molecule significantly influences lipoprotein metabolism via the low‐density lipoprotein receptor‐related protein (LRP) 1. Our findings are instrumental in understanding the pathology of various
Hiroto Matsuura, Shogo Akahane, Takahiro Kaido, Tomu Kamijo, Kenta Sakamoto, Kazuyoshi Yamauchi   +5 more
wiley   +1 more source

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes

Journal of Lipid Research, 1999
Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of remnant lipoproteins in the plasma and development of premature atherosclerosis. Although receptor binding-defective forms of apolipoprotein (apo) E are the common
Robert W. Mahley, Yadong Huang, Stanley C. Rall, Jr.   +2 more
doaj  

n-Linear Algebra of type II [PDF]

Published by InfoLearnQuest, Ann Arbor, United States in 2008, 2009
This book is a continuation of the book n-linear algebra of type I and its applications. Most of the properties that could not be derived or defined for n-linear algebra of type I is made possible in this new structure: n-linear algebra of type II which is introduced in this book.
arxiv  

The Ep,i - Eiso correlation: type I gamma-ray bursts and the new classification method [PDF]

, 2019
We present the most extensive sample of 45 type I (short) and 275 type II (long) gamma-ray bursts (GRB) with known redshift to investigate the correlation between the rest frame peak energy, Ep,i and the total isotropic equivalent energy, Eiso of the prompt emission (Amati relation).
arxiv   +1 more source