Results 71 to 80 of about 11,928,997 (202)

Clinical, Anthropometric and Biochemical Characteristics of Patients with or without Genetically Confirmed Familial Hypercholesterolemia

Arquivos Brasileiros de Cardiologia
Background: Familial hypercholesterolemia (FH) is a common autosomal dominant disorder, characterized by a high level of low-density lipoprotein cholesterol (LDL-C) and a high risk of premature cardiovascular disease. Objective: To evaluate clinical and
Andrea De Lorenzo, Juliana Duarte Lopes da Silva, Cinthia E. James, Alexandre C. Pereira, Annie Seixas Bello Moreira   +4 more
doaj   +1 more source

Two‐year outcomes of a cardiac microcurrent device in chronic heart failure: A first‐in‐human pilot study

ESC Heart Failure, Volume 12, Issue 5, Page 3264-3275, October 2025.
Abstract Aims In heart failure patients, altered myocardial electrical fields linked to oedema may impair left ventricular function. While short‐term use of implanted microcurrent generators (C‐MIC) has shown promise, long‐term effects remain unclear.
Dragana B. Kosevic, Una Radak, Petar Vukovic, Jan D. Schmitto, Kersten Brandes, Peter Goettel, Hans‐Dirk Duengen, Elvis Tahirovic, Marija Zdravkovic, Johannes Mueller, Faouzi Kallel, Marat Fudim, Stefan D. Anker, Jesus Eduardo Rame, Miodrag Peric   +14 more
wiley   +1 more source

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]

, 2010
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
Rabbani, Naila, D. Zehnder, A. Ceriello, P. J. Thornalley, N. Rabbani, Zehnder, Daniel, Chittari, Madhu Varma, C. W. Bodmer, Bodmer, Charles W., Ceriello, Antonio, M. V. Chittari, Thornalley, Paul J.   +11 more
core   +1 more source

Facilitators, barriers, and insights using an HFA‐PEFF‐based clinical decision support system: A proof‐of‐concept study

ESC Heart Failure, Volume 12, Issue 5, Page 3655-3666, October 2025.
Analysis of the usage of the HFA‐PEFF score‐based clinical decision support system (CDSS) and the main barriers and facilitators to its implementation, based on a survey of physicians. Abstract Background and aims Knowing that heart failure (HF) with preserved ejection fraction (HFpEF) can be difficult to diagnose, a clinical decision support system ...
Isidora Milosavljević, Ivan Petrović, Aleksandra Ilić, Dragana Dabović, Aleksandra Milovančev, Goran Remer, Vladimir Vuković, Dimitrije Zdravković, Maja Stefanović, Snežana Stojšić, Ana Balenović, Goran Lončar, Snežana Tadić, Milana Jaraković, Snežana Bjelić, Snežana Čemerlić, Marija Bjelobrk, Tatjana Miljković, Andrej Preveden, Milovan Petrović, Srdjan Maletin, Tanja Popov, Vanja Drljević Todić, Mirko Todić, Aleksandra Vulin, Milenko Čanković, Dragica Andrić, Dragoslava Živkov Šaponja, Aleksandar Redžek, Anastazija Stojšić Milosavljević   +29 more
wiley   +1 more source

Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 --> Cys) homozygotes is associated with hyperinsulinemia [PDF]

, 2002
Type III hyperlipoproteinemia (HLP) is mainly found in homozygous carriers of apolipoprotein E2 (apoE2, Arg158-->Cys). Only a small percentage ( or = 50 years had significantly higher plasma lipid levels than their counterparts aged < 50 years.
Hoogerbrugge, N., Hoogerbrugge-van der Linden, N., Duijn, C.M. (Cornelia) van, Havekes, LM, Stalenhoef, A.F.H., Kastelein, J.J.P. (John), Gevers Leuven, J.A., Havekes, Louis M., Hoogerbrugge, N, Stalenhoef, A.F., Kastelein, J.J.P., John J.P. Kastelein, Havekes, L.M., van Duijn, Cornelia M., de Beer, Femke, Gevers Leuven, Jan A., Kastelein, JJ, Louis M. Havekes, Gevers Leuven, JA, Augustinus H.M. Smelt, Smelt, Augustinus H. M., Leuven, J.A.G., Stalenhoef, AFH, Beer, F. de, Smelt, AHM, Hoogerbrugge, N. (Nicoline), Smelt, A.H., Jan A. Gevers Leuven, Stalenhoef, Anton F. H., Nicoline Hoogerbrugge, Beer, F. (Femke) de, de Beer, F, Cornelia M. van Duijn, Duijn, C.M. van, Anton F.H. Stalenhoef, Femke de Beer, Duijn, Cornelia, Hoogerbrugge, Nicoline, Smelt, A.H.M., Kastelein, John J. P.   +39 more
core   +3 more sources

Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by tau pathology, leading to neurodegeneration. Astrocytes regulate central nervous system homeostasis and influence AD progression. The APOE3‐Christchurch (APOE3‐Ch) variant is linked to AD resilience, but its protective mechanisms remain unclear.
Xinran Tian, Erica Keane Rivera, Inyoung Hwang, Arina A. Nikitina, Jennifer A. Smith, Youngsuh J. Cho, Julia Sala‐Jarque, Austin DuBose, Clare Andriola, Toby Gollan‐Myers, Kenneth S. Kosik   +10 more
wiley   +1 more source

A Case of Type V Hyperlipoproteinemia with Xanthoma Eruptivum

, 2001
We report a case of type V hyperlipoproteinemia with xanthoma eruptivum in a 30-year-old male. He had diffuse erythematous yellowish papules on both extremities and the buttock.
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Coronary Artery Bypass Grafting on Microaxial Flow Pump Support in Patients With Severely Reduced Left Ventricular Ejection Fraction

Artificial Organs, Volume 49, Issue 8, Page 1346-1355, August 2025.
Coronary artery revascularization with microaxial flow pump support in patients with severely reduced left ventricular ejection fraction is an emerging technique in cardiac surgery. In this manuscript, we present early results, highlight the advantages, and discuss the key limitations of this approach.
Gaik Nersesian, Daniel Lewin, Yuriy Hrytsyna, Pia Lanmueller, Sascha Ott, Nicolas Merke, Volkmar Falk, Felix Schoenrath, Evgenij Potapov, Alaa Abd El Al   +9 more
wiley   +1 more source

Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome [PDF]

, 1987
The mechanism leading to hyperlipidemia in the nephrotic syndrome is not fully understood but may be related in part to loss of high density lipoproteins in the urine of patients with nephrosis.
Caselmann, Wolfgang H., Kutschera, P., Weisweiler, P., Jüngst, Dieter   +3 more
core   +1 more source

Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder beneficiaries participating in the Open Genome Project

Annals of Human Genetics, Volume 89, Issue 4, Page 208-227, July 2025.
Abstract Introduction An ethics‐guided decision‐making framework was developed for applying pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that translates population risk stratification into clinical utility. We introduce this service, supported by the Open Genome Project, which aligns with the beneficence principle in ...
Manie De Klerk, Nicole Van Der Merwe, Johny Erasmus, Lindiwe Whati, Kelebogile E. Moremi, Daniel W. Olivier, Maritha J. Kotze   +6 more
wiley   +1 more source