Physiological Reports, Volume 13, Issue 10, May 2025.Abstract Atherosclerosis is a chronic inflammatory disease of the blood vessels caused by elevated levels of lipoproteins. The hyperlipoproteinemia triggers a series of cellular changes, particularly the activation of the macrophages, which play a crucial role in the development and progression of atherosclerosis.
Karel Paukner +8 more
wiley +1 more source
Retardation of atherosclerosis in immunocompetent apolipoprotein (apo) E-deficient mice followingliver-directed administration of a [E1-, E3-,polymerase-] adenovirus vector containing the elongation factor-1a promoter driving expression of human apoE cDNA [PDF]
, 2005 Although gene transfer of human apolipoprotein E (apoE), a 34-kDa circulating glycoprotein, to the liver of apoEdeficient(apoE-/-) mice using recombinant adenoviral vectors (rAd) is antiatherogenic, its full therapeutic potentialhas yet to be realized ...
Amalfitano, A +6 more
core
Revisiting the genetics of APOE [PDF]
, 2017 Apolipoprotein E (APOE) is a lipid-transport protein expressed in almost all tissues, including the brain. In addition to lipid delivery, brain APOE also regulates amyloid beta clearance and aggregation.
Brás, J +3 more
core
Nutritional aspects of studying vegetable marrows and Zucchini fruits
Annals of Mechnikov's InstituteIntroduction. Nutrition forms the foundation of human life and is one of the most vital factors in reducing the risk of developing nutrition-related diseases. It helps ensure active longevity and supports the body's adaptive potential.
Olena Iosipenko +5 more
doaj +1 more source
Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease [PDF]
, 1992 Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary ...
Abell +59 more
core +1 more source
Apolipoprotein E delivery by peritoneal implantation of encapsulated recombinant cells improves the hyperlipidaemic profile in apoE-deficient mice [PDF]
, 2005 Plasma apolipoprotein E (apoE) is a 34-kDa polymorphic protein which has atheroprotective actions by clearing remnant lipoproteins and sequestering excess cellular cholesterol.
Diakonov, IA +7 more
core
The influence of portal blood upon lipid metabolism in normal and diabetic dogs and baboons [PDF]
, 1975 It has been reported that hyperlipidemia can be alleviated in human beings with an end to side portacaval shunt. Understanding the mechanism of the effect has important implications, including the possibility of devising other ways of lowering serum ...
Lee, IY +3 more
core
Working note-book for the practical classes on biochemistry [PDF]
, 2013 БИОХИМИ
Buyanova, S. V., Konevalova, N. Yu.
core
Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats [PDF]
, 2010 We investigated the influence of high sucrose diet (HSD) after 3 or 5 weeks of administration on paraoxonase 1 (PON1) activity in plasma of normolipidemic rats and the relationship between serum PON1 activity, triacylglycerides (TGs), HDL and total ...
Bradamante, Vlasta +4 more
core
Portal Diversion: Treatment for Glycogen Storage Disease and Hyperlipemia [PDF]
, 1975 Putnam, CW, Starzl, TE
core +1 more source