Rebalancing the Neurovascular Axis: NTRK2 Isoform Equilibrium as a Determinant of Pulmonary Endothelial Regeneration. [PDF]
Zhou G, Tan C, Miao Y.
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Quantitative proteomics links mitochondrial dysfunction to metabolic changes and epithelial differentiation defects in hyperoxia-exposed neonatal airway cells. [PDF]
Ganguly A +9 more
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Pharmacologic Inhibition of S-Nitrosoglutathione Reductase Prevents Hyperoxic Alveolar and Airway Disease in Newborn Mice. [PDF]
Adaikalam S +7 more
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Caffeine Protects Against Hyperoxia-Induced Structural Lung Injury and Restores Alveolar Development in Neonatal Rats. [PDF]
Endesfelder S, Bührer C.
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Integrative single-cell RNA and ATAC sequencing reveals the impact of chronic cigarette smoking on lung epithelial responses to influenza and hyperoxia. [PDF]
Cha PC +7 more
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Mitochondrial quality control mechanisms as molecular targets for impaired lung development: from fetuses to neonates. [PDF]
Zhu Z, Zhang L, Fu J.
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We hypothesized that tissue hyperoxia would enhance and hypoxia inhibit neovascularization in a wound model. Therefore, we used female Swiss‐Webster mice to examine the influence of differential oxygen treatment on angiogenesis. One milliliter plugs of Matrigel®, a mixture of matrix proteins that supports but does not itself elicit angiogenesis, were ...
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Surgical wound infection remains a common and serious complication of surgery. Patient factors are a major determinant of wound outcome following surgery. Co-morbidities clearly contribute, but environmental stressors as well the individual response to stress may be equally important. In particular, wounds are exquisitely sensitive to hypoxia, which is
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Hypoxic ventilatory responses in rats after hypercapnic hyperoxia and intermittent hyperoxia
Respiratory Physiology and Neurobiology, 2007Perinatal hyperoxia attenuates the adult hypoxic ventilatory response in rats. Hyperoxia might elicit this plasticity by inhibiting chemoreceptor activity during early life. Thus, we hypothesized that stimulating chemoreceptors with CO(2) during hyperoxia or interrupting hyperoxia with periods of normoxia would reduce the effects of hyperoxia on the ...
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The current practice of mechanical ventilation comprises the use of the least inspiratory O2 fraction associated with an arterial O2 tension of 55 to 80 mm Hg or an arterial hemoglobin O2 saturation of 88% to 95%. Early goal-directed therapy for septic shock, however, attempts to balance O2 delivery and demand by optimizing cardiac function and ...
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